Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry

Biomedical Chromatography

Volumn 16, Issue 8, 2002, Pages 529-535

  Deventer, K ^a   Delbeke, Frans T ^a   Roels, K ^a   Van Eenoo, P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; HIGH PRESSURE LIQUID CHROMATOGRAPHY;

DOPING ANALYSIS; FAST LIQUID CHROMATOGRAPHIES; HUMAN URINE; LC-MS-MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; PROBENECID; SELECTIVE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRIC;

MASS SPECTROMETRY;

ACETAZOLAMIDE; ACETIC ACID ETHYL ESTER; AMILORIDE; BENDROFLUMETHIAZIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUMETANIDE; CANRENONE; CHLORTALIDONE; CLOPAMIDE; CORTICOSTEROID DERIVATIVE; DICLOFENAMIDE; DIURETIC AGENT; DOCSPIROCHLOR; EPITIZIDE; ETACRYNIC ACID; FRUMIL; FUROSEMIDE; HYDROCHLOROTHIAZIDE; INDAPAMIDE; MEFRUSIDE; NARCOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PIRETANIDE; PROBENECID; SPIRONOLACTONE; TORASEMIDE; TRIAMTERENE; TRICHLORMETHIAZIDE; XIPAMIDE;

ANALYTICAL EQUIPMENT; ARTICLE; CONTROLLED STUDY; DOPING; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SCREENING; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; METABOLIC RATE; NORMAL HUMAN; TANDEM MASS SPECTROMETRY; URINALYSIS;

EID: 0036924505     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.201     Document Type: Article

References (18)

1. Barroso MB, Meiring HD, de Jong A, Alonso RM and Jiménez RM. Gas chromatographic-mass spectrometric analysis of the loop diuretic torasemide in human urine. Journal of Chromatography B 1997; 690: 105.
2. Campins-Falco P, Herraéz- Hernandez R, and Sevillano-Cabeza A. Solid-phase extraction techniques for assay of diuretics in human urine samples. Journal of Liquid Chromatography 1991; 14: 723.
3. Carreras D, Imaz C, Navajas R, Garcia MA, Rodriguez C, Rodriguez AF and Cortes R. Comparison of derivatization procedures for the determination of diuretics in urine by gas chromatography-mass spectrometry. Journal of Chromatography B 1994; 683: 195.
4. Cooper SF, Massé R and Dugal R. Comprehensive screening-procedure for diuretics in urine by high-performance liquid chromatography. Journal of Chromatography 1989: 489: 65.
5. Delbeke FT and Debackere M. The influence of diuretics on the excretion and metabolism of doping agents. Biopharmacy and Drug Disposition 1988: 9: 137.
6. Eurachem Working Group. A Laboratory Guide to Method Validation and Related Topics. Eurachem: Teddington, 1998.
7. Garbis SD, Hanley L and Kalita S. The detection of thiazide based diuretics in equine urine by LC/ESI/MS and LC/APCI/MS. Journal of AOAC. International 1998: 89: 948.
8. IOC. The International Olympic Committee Analytical Criteria for Reporting low Concentrations of Anabolic Steroids. Internal Communication. IOC: Lausanne. 1998.
9. IOC. Olympic Movement Anti-Doping Code. Prohibited Classes of Substances and Prohibited Methods. IOC: Lausanne, 2001: Appendix A.
10. Jankowski A, Skorek-Jankowska A and Lamparczyck H. Determination and pharmacokinetics of a furosemide-amiloride drug combination. Journal Chromatography B 1997; 693: 383.
11. Moffat AC. Clarke's Isolation and Identification of Drugs. The Pharmaceutical Press: London, 1986.
12. Park SJ, Pyo HS, Kim YJ, Kim MS and Park J. Systematic analysis of diuretic doping agents by HPLC Screening and GC/MS Confirmation. Journal of Analytical Toxicology 1990; 14: 84.
13. Rosado MA, Gasco LA, Santos MA and Izquierdo HR. High-performance liquid chromatographic seperation of a complex mixture of diuretics using a micellar mobile phase of sodium dodecyl sulphate. Journal of Chromatography B 2000; 748: 415.
14. Sanz-Nebot V, Toro I, Bergés R, Ventura R, Segura J and Barbosa J. Determination and characterization of diuretics in human urine by liquid chromatography coupled to pneumatically assisted electrospray ionisation mass spectrometry. Journal of Mass Spectrometry 2001; 36: 652.
15. Thieme D, Grosse J, Lang R, Mueller RK and Whal A. Screening, confirmation and quantitation of diuretics in urine for doping control analysis by high-performance liquid chromatography-atmospheric pressure ionisation tandem mass spectrometry. Journal of Chromatography B 2001; 757: 49.
16. Tisdall PA, Moyer TP and Anhalt JP. Liquid chromatographic detection of thiazide diuretics in urine. Clinical Chemistry 1980; 26: 702.
17. Tsai FY, Lui LF and Chang B. Analysis of diuretic doping agents by HPLC screening and GC-MSD confirmation. Journal of Pharmaceutical and Biomedical Analysis 1991; 9: 1069.
18. Ventura R and Segura J. Detection of diuretic agents in doping control. Journal of Chromatography B 1996: 687: 127.