Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 11, 2012, Pages 4122-4127

  Lukk, Tiit ^a   Sakai, Ayano ^a   Kalyanaraman, Chakrapani ^b   Brown, Shoshana D ^b,d   Imker, Heidi J ^a   Song, Ling ^a   Fedorov, Alexander A ^c   Fedorov, Elena V ^c   Toro, Rafael ^c   Hillerich, Brandan ^c   Seidel, Ronald ^c   Patskovsky, Yury ^c   Vetting, Matthew W ^c   Nair, Satish K ^a   Babbitt, Patricia C ^b,d   Almo, Steven C ^a,c   Gerlt, John A ^a   Jacobson, Matthew P ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d University of California   (United States)

Author keywords

Computational biology; Enzymology; Protein function

Indexed keywords

ALANINE; DIPEPTIDE DERIVATIVE; ENOLASE; EPIMERASE; GLUTAMIC ACID; PEPTIDOGLYCAN; PHENYLALANINE;

ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; CYTOPHAGA; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; HYDROPHOBICITY; METABOLITE; MOLECULAR DOCKING; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE HOMOLOGY;

CATALYTIC DOMAIN; CATIONS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, MOLECULAR; MULTIGENE FAMILY; PHOSPHOPYRUVATE HYDRATASE; RACEMASES AND EPIMERASES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS; CYTOPHAGA HUTCHINSONII;

EID: 84858260654     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112081109     Document Type: Article

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