Computation-facilitated assignment of the function in the enolase superfamily: A regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis

Biochemistry

Volumn 48, Issue 48, 2009, Pages 11546-11558

  Rakus, John F ^a   Kalyanaraman, Chakrapani ^b   Fedorov, Alexander A ^c   Fedorov, Elena V ^c   Mills Groninger, Fiona P ^a   Toro, Rafael ^c   Bonanno, Jeffrey ^c   Bain, Kevin ^d   Sauder, J Michael ^d   Burley, Stephen K ^d   Almo, Steven C ^c   Jacobson, Matthew P ^b   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE ARCHITECTURE; ACTIVE SITE STRUCTURE; BIFUNCTIONAL; COMPUTATIONAL APPROACH; CONVERGENT EVOLUTION; ENOLASE; ENZYME PRODUCTS; GENOME PROJECTS; IN-SILICO; LEAVING GROUPS; NEW YORK; REACTION CATALYZED; RESEARCH CENTER; STRUCTURAL GENOMICS; STRUCTURE-BASED;

ABSTRACTING; ACIDS; ENZYMES;

SUGAR (SUCROSE);

ENOLASE; GALACTARATE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; NONHUMAN; OCEANOBACILLUS IHEYENSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY;

BACILLACEAE; CATALYTIC DOMAIN; CATIONS, DIVALENT; COMPUTATIONAL BIOLOGY; HYDRO-LYASES; KINETICS; MAGNESIUM; MODELS, MOLECULAR; PHOSPHOPYRUVATE HYDRATASE; SUGAR ACIDS;

OCEANOBACILLUS IHEYENSIS;

EID: 73149104175     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901731c     Document Type: Article

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