Architecture of kangaroo rat inner medulla: Segmentation of descending thin limb of Henle's loop

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 302, Issue 6, 2012, Pages 720-726

  Urity, Vinoo B ^a   Issaian, Tadeh ^a   Braun, Eldon J ^a   Dantzler, William H ^a   Pannabecker, Thomas L ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Aquaporin; CLC K1; Concentrating mechanism; Urea transport

Indexed keywords

AQUAPORIN 1; AQUAPORIN 2; CHLORIDE CHANNEL; WHEAT GERM AGGLUTININ;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CHLORIDE TRANSPORT; CONTROLLED STUDY; FEMALE; HENLE LOOP; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY SLICE; KIDNEY TUBULE; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT KANGAROO; TISSUE SECTION; URINE OSMOLALITY; WATER ABSORPTION; WISTAR RAT;

ANIMALS; AQUAPORIN 1; AQUAPORIN 2; CHLORIDE CHANNELS; DIPODOMYS; FEMALE; KIDNEY MEDULLA; LOOP OF HENLE; MALE; RATS, WISTAR;

EID: 84858203635     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00549.2011     Document Type: Article

References (43)

1. Akizuki N, Uchida S, Sasaki S, Marumo F. Impaired solute accumulation in inner medulla of Clcnk1-/- mice kidney. Am J Physiol Renal Physiol 280: F79-F87, 2001.
2. Bankir L, De Rouffignac C. Urinary concentrating ability: insights from comparative anatomy. Am J Physiol Regul Integr Comp Physiol 249: R643-R666, 1985.
3. Bankir L, Kriz W. Adaptation of the kidney to protein intake and to urine concentrating activity: similar consequences in health and CRF. Kidney Int 47: 7-24, 1995.
4. Barrett JM, Kriz W, Kaissling B, De Rouffignac C. The ultrastructure of the nephrons of the desert rodent (Psammonys obesus) kidney. II. Thin limbs of Henle of long-looped nephrons. Am J Anat 151: 499-514, 1978.
5. Beuchat CA. Body size, medullary thickness, and urine concentrating ability in mammals. Am J Physiol Regul Integr Comp Physiol 258: R298-R308, 1990.
6. Chou CL, Knepper MA, Van Hoek AN, Brown D, Ma T, Verkman AS. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest 103: 491-496, 1999.
7. Chou CL, Knepper MA. In vitro perfusion of chinchilla thin limb segments: segmentation and osmotic water permeability. Am J Physiol Renal Fluid Electrolyte Physiol 263: F417-F426, 1992.
8. Chou CL, Knepper MA. In vitro perfusion of chinchilla thin limb segments: urea and NaCl permeabilities. Am J Physiol Renal Fluid Electrolyte Physiol 264: F337-F343, 1993.
9. Chou CL, Nielsen S, Knepper MA. Structural-functional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment. Am J Physiol Renal Fluid Electrolyte Physiol 265: F863-F874, 1993.
10. Dantzler WH, Evans KK, Pannabecker TL. Osmotic water permeabilities in specific segments of rat inner medullary thin limbs of Henle's loops (Abstract). FASEB J 23: 970.3, 2009.
11. Jentsch TJ, Friedrich T, Schriever A, Yamada H. The CLC chloride channel family. Pflügers Arch 437: 783-795, 1999.
12. Kaissling B, De Rouffignac C, Barrett JM, Kriz W. The structural organization of the kidney of the desert rodent Psammomys obesus. Anat Embryol 148: 121-143, 1975.
13. Kaissling B, Kriz W. Morphology of the loop of Henle, distal tubule, and collecting duct. In: Handbook of Physiology. Sec. 8. Renal Physiology, edited by Windhager EE. New York: Oxford University Press, 1992, p. 109-167.
14. Kim J, Pannabecker TL. Two-compartment model of inner medullary vasculature supports dual modes of vasopressin-regulated inner medullary blood flow. Am J Physiol Renal Physiol 299: F273-F279, 2010.
15. Knepper MA, Saidel GM, Hascall VC, Dwyer T. Concentration of solutes in the renal inner medulla: interstitial hyaluronan as a mechanoosmotic transducer. Am J Physiol Renal Physiol 284: F433-F446, 2003.
16. Kokko JP, Rector FC. Countercurrent multiplication system without active transport in inner medulla. Kidney Int 2: 214-223, 1972.
17. Kriz W. Structural organization of the renal medulla: comparative and functional aspects. Am J Physiol Regul Integr Comp Physiol 241: R3-R16, 1981.
18. Layton AT. A mathematical model of the urine concentrating mechanism in the rat renal medulla: II. Functional implications of three-dimensional architecture. Am J Physiol Renal Physiol 300: F372-F384, 2011.
19. Layton AT, Gilbert RL, Pannabecker TL. Isolated interstitial nodal spaces may facilitate preferential solute and fluid mixing in the rat renal inner medulla. Am J Physiol Renal Physiol In press.
20. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Two modes for concentrating urine in rat inner medulla. Am J Physiol Renal Physiol 287: F816-F839, 2004.
21. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Functional implications of the three-dimensional architecture of the rat renal inner medulla. Am J Physiol Renal Physiol 298: F973-F987, 2010.
22. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Hyperfltration and inner-stripe hypertrophy may explain fndings by Gamble and co-workers. Am J Physiol Renal Physiol 298: F962-F972, 2010.
23. Layton HE. Concentrating urine in the inner medulla of the kidney. Comments Theor Biol 1: 179-196, 1989.
24. Lemley KV, Kriz W. Cycles and separations: the histotopography of the urinary concentrating process. Kidney Int 31: 538-548, 1987.
25. McLean IW, Nakane PK. Periodate-lysine-paraformaldehyde fixative: a new fixative for immunoelectron microscopy. J Histochem Cytochem 22: 1077-1083, 1974.
26. Nielsen S, Frokiaer J, Marples D, Kwon TH, Agre P, Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
27. Pannabecker TL. Loop of Henle interaction with interstitial nodal spaces in the renal inner medulla. Am J Physiol Renal Physiol 295: F1744-F1751, 2008.
28. Pannabecker TL. Structure and function of the thin limbs of the loops of Henle. In: Comprehensive Physiology. Hoboken NJ: Wiley, In press.
29. Pannabecker TL, Abbott DE, Dantzler WH. Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop. Am J Physiol Renal Physiol 286: F38-F45, 2004.
30. Pannabecker TL, Dantzler WH. Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts. Am J Physiol Renal Physiol 287: F767-F774, 2004.
31. Pannabecker TL, Dantzler WH. Three-dimensional architecture of inner medullary vasa recta. Am J Physiol Renal Physiol 290: F1355-F1366, 2006.
32. Pannabecker TL, Dantzler WH. Three-dimensional architecture of collecting ducts, loops of Henle, and blood vessels in the renal papilla. Am J Physiol Renal Physiol 293: F696-F704, 2007.
33. Pannabecker TL, Dantzler WH, Layton HE, Layton AT. Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla. Am J Physiol Renal Physiol 295: F1271-F1285, 2008.
34. Pannabecker TL, Henderson C, Dantzler WH. Quantitative analysis of functional reconstructions reveals lateral and axial zonation in the renal inner medulla. Am J Physiol Renal Physiol 294: F1306-F1314, 2008.
35. Pruitt MEC, Knepper MA, Graves B, Schmidt-Nielsen B. Effect of peristaltic contractions of the renal pelvic wall on solute concentrations of the renal inner medulla in the hamster. Am J Physiol Renal Physiol 290: F892-F896, 2006.
36. Sands JM, Layton HE. The urine concentrating mechanism and urea transporters. In: The Kidney: Physiology and Pathophysiology, edited by Alpern RJ and Hebert SC. Philadelphia, PA: Elsevier, 2007, p. 1143-1177.
37. Schmidt-Nielsen B, Schmidt-Nielsen K, Brokaw A, Schneiderman H. Water conservation in desert rodents. J Cell Comp Physiol 32: 331-360, 1948.
38. Schwartz MM, Venkatachalam MA. Structural differences in thin limbs of Henle: physiological implications. Kidney Int 6: 193-208, 1974.
39. Stephenson JL. Concentration of urine in a central core model of the renal counterflow system. Kidney Int 2: 85-94, 1972.
40. Uchida S, Sasaki S, Furakawa T, Hiraoka M, Imai T, Hirata Y, Marumo F. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in the kidney medulla. J Biol Chem 268: 3821-3824, 1993.
41. Uchida S, Sasaki S, Nitta K, Uchida K, Horita S, Nihei H, Marumo F. Localization and functional characterization of rat kidney-specific chloride channel. J Clin Invest 95: 104-113, 1995.
42. Vimtrup BJ, Schmidt-Nielsen B. The histology of the kidney of kangaroo rats. Anat Rec 114: 515-528, 1952.
43. Yuan J, Pannabecker TL. Architecture of inner medullary descending and ascending vasa recta: pathways for countercurrent exchange. Am J Physiol Renal Physiol 299: F265-F272, 2010.