Hyperfiltration and inner stripe hypertrophy may explain findings by Gamble and coworkers

American Journal of Physiology - Renal Physiology

Volumn 298, Issue 4, 2010, Pages

  Layton, Anita T ^a   Pannabecker, Thomas L ^b   Dantzler, William H ^b   Layton, Harold E ^a  

^a DUKE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Countercurrent system; Mathematical model; NaCl transport; Renal inner medulla; Urea transport; Urine concentrating mechanism

Indexed keywords

SODIUM CHLORIDE; UREA;

ARTICLE; COMPUTER SIMULATION; HYPOTHESIS; KIDNEY BLOOD FLOW; KIDNEY CONCENTRATING CAPACITY; KIDNEY CORTEX; KIDNEY MEDULLA; MATHEMATICAL MODEL; PRIORITY JOURNAL; URINE FLOW RATE; URINE OSMOLALITY;

EID: 77950847331     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00250.2009     Document Type: Article

References (46)

1. Atherton JC, Hai MA, Thomas S. The time course of changes in renal tissue composition during water diuresis in the rat. J Physiol 197: 429-443, 1968.
2. Bankir L, Fischer C, Fischer S, Jukkala K, Specht HC, Kriz W. Adaptation of the rat kidney to altered water intake and urine concentration. Pflügers Arch 412: 42-53, 1988.
3. Bankir L, Kriz W. Adaptation of the kidney to protein intake and to urine concentrating activity: similar consequences in health and CRF. Kidney Int 47: 7-24, 1995.
4. Beck F, Dörge A, Rick R, Thurau K. Intra- and extracellular element concentrations of rat renal papilla in antidiuresis. Kidney Int 25: 397-403, 1984.
5. Bonvalet JP, Champion M, Courtalon A, Farman N, Vandewalle A, Wanstok F. Number of glomeruli in normal and hypertensive kidneys of mice and guinea-pigs. J Physiol 269: 627-641, 1977.
6. Bonventre JV, Lechene C. Renal medullary concentrating process: an integrative hypothesis. Am J Physiol Renal Fluid Electrolyte Physiol 239: F578-F588, 1980.
7. Bouby N, Trinh-Trang-Tan M.-M., Laouari D., Kleinknecht C., Grunfeld J.-P., Kriz W., Bankir L., Doute M., Hahnel B., Coutaud C. Role of the urine concentrating process in the renal effects of high protein intake. Kidney Int 34: 4-12, 1988.
8. Chen J, Edwards A, Layton AT. A mathematical model of oxygen transport in the rat outer medulla. II. Impacts of outer medullary architecture. Am J Physiol Renal Physiol 297: F537-F548, 2009.
9. Collins BG. Water metabolism and the distribution of two species of Australian murids, Rattus rattus and Rattus villosissimus. Comp Biochem Physiol 61A: 647-651, 1978.
10. Fenton RA, Chou CL, Stewart GS, Smith CP, Knepper MA. Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. PNAS 101: 7469-7474, 2004.
11. Fenton RA, Chou CL, Sowersby H, Smith CP, Knepper MA. Gamble's "economy of water" revisited: studies in urea transporter knockout mice. Am J Physiol Renal Physiol 291: F148-F154, 2006.
12. Gamble JL, McKhann CF, Butler AM, Tuthill E. An economy of water in renal function referable to urea. Am J Physiol 109: 139-154, 1934.
13. Gottschalk CW, Lassiter WE, Mylle M, Ullrich KJ, Schmidt-Nielsen B, O'Dell R, Pehling G. Micropuncture study of composition of loop of Henle fluid in desert rodents. Am J Physiol 204: 532-535, 1963.
14. Gottschalk CW, Mylle M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196: 927-936, 1959.
15. Hai MA, Thomas S. The time-course of changes in renal tissue composition during lysine vasopressin infusion in the rat. Pflügers Arch 310: 297-319, 1969.
16. Hendrikx A, Epstein FH. Effect of feeding protein and urea on renal concentrating ability in the rat. Am J Physiol 195: 539-542, 1958.
17. Hervy S, Thomas SR. Inner medullary lactate production and urineconcentrating mechanism: a flat medullary model. Am J Physiol Renal Physiol 284: F65-F81, 2003.
18. Iitake K, Kimura T, Ota K, Shoji M, Inoue M, Ohta M, Sato K, Yamamoto T, Yasujima M, Abe K, Yoshinaga K. Responses of vasopressin, atrial natriuretic piptide, and blood pressure to central osmotic stimulation. Am J Physiol Endocrinol Metab 257: E611-E616, 1989.
19. Jamison RL, Kriz W. Urinary Concentrating Mechanism: Structure and Function. Oxford, UK: Oxford University Press, New York, 1982.
20. Jen JF, Wang H, Tewarson RP, Stephenson JL. Comparison of central core and radially separated models of renal inner medulla. Am J Physiol Renal Fluid Electrolyte Physiol 268: F693-F697, 1995.
21. Kato A, Naruse M, Knepper MA, Sands JM. Long-term regulation of inner medullary collecting duct urea transport in rat. J Am Soc Nephrol 9: 737-745, 1998.
22. Knepper MA. Measurement of osmolality in kidney slices using vapor pressure osmometry. Kidney Int 21: 653-655, 1982.
23. Layton AT, Layton HE. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. I. Formulation and base-case results. Am J Physiol Renal Physiol 289: F1346-F1366, 2005.
24. Layton AT, Layton HE. A region-based mathematical model of the urine concentrating mechanism in the rat outer medulla. II. Parameter sensitivity and tubular inhomogeneity. Am J Physiol Renal Physiol 289: F1367-F1381, 2005.
25. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Two modes for concentrating urine in the rat inner medulla. Am J Physiol Renal Physiol 287: F816-F839, 2004.
26. Layton AT, Pannabecker TL, Dantzler WH, Layton HE. Functional implications of the three-dimensional architecture of the rat renal inner medulla. Am J Physiol Renal Physiol 298: F973-F987, 2010.
27. Layton HE. Mathematical models of the mammalian urine concentrating mechanism. In: Membrane Transport and Renal Physiology, The IMA Volumes in Mathematics and Its Applications, edited by Layton HE and Weinstein AM. New York: Springer, 2002, p. 233-272.
28. Layton HE, Knepper MA, Chou CL. Permeability criteria for effective function of passive countercurrent multiplier. Am J Physiol Renal Fluid Electrolyte Physiol 270: F9-F20, 1996.
29. Ludwig M, Horn T, Callahan MF, Grosche A, Morris M, Landgraf R. Osmotic stimulation of the supraoptic nucleus: central and peripheral vasopressin release and blood pressure. Am J Physiol Endocrinol Metab 266: E351-E356, 1994.
30. MacKay LL, MacKay E, Addis T. Factors which determine renal weight: XII. The nitrogen intake as varied by the addition of urea to the diet. J Nutr 4: 379-383, 1928.
31. Pannabecker TL, Abbott DE, Dantzler WH. Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop. Am J Physiol Renal Physiol 286: F38-F45, 2004.
32. Pannabecker TL, Dantzler WH, Layton HE, Layton AT. Role of three-dimensional architecture in the urine concentrating mechanism of the rat renal inner medulla. Am J Physiol Renal Physiol 295: F1217-F1285, 2008.
33. Sands JM, Layton HE. The urine concentrating mechanism and urea transporters. In: Seldin and Giebisch's The Kidney: Physiology and Pathophysiology (4th ed.), edited by Alpern RJ and Hebert SC. New York: Elsevier, 2007, p. 1143-1178.
34. 2O transport in inner medullary collecting duct subsegments. Am J Physiol Renal Fluid Electrolyte Physiol 253: F823-F832, 1987.
35. Sonnenberg H. Medullary collecting-duct function in antidiuretic and in salt- or water-diuretic rats. Am J Physiol 226: 501-506, 1974.
36. Stephenson JL. Urinary concentration and dilution: models. In: Handbook of Physiology. Renal Physiology. Bethesda, MD: Am Physiol Soc, 1992, sect. 8, vol.II, chapt. 30, p. 1349-1408.
37. Stephenson JL, Jen JF, Wang H, Tewarson RP. Convective uphill transport of NaCl from ascending thin limb of the loop of Henle. Am J Physiol Renal Fluid Electrolyte Physiol 268: F680-F692, 1995.
38. Stephenson JL, Zhang Y, Tewarson R. Electrolyte, urea, and water transport in a two-nephron central core model of the renal medulla. Am J Physiol Renal Fluid Electrolyte Physiol 257: F399-F413, 1989.
39. Ullrich KJ, Jarausch KH. Untersuchungen zum Problem der Harnkonzentrierung and Harnverdünnung Ueber der Verteilung von Electrolyten (Na, K, Ca, Mg, Cl, anorganischem Phosphat), Harnstoff, Aminosäuren and exorgenem Kreatinin in Rinde und Mark der Hundeniere bei verschiedenen Dieresezuständen. Pflügers Arch 262: 537-550, 1956.
40. Wade JB, Lee AJ, Ecelbarger CA, Mitchell C, Bradford AD, Terris J, Kim GH, Knepper MA. UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. Am J Physiol Renal Physiol 278: F52-F62, 2000.
41. Wang X, Thomas SR, Wexler AS. Outer medullary anatomy and the urine concentrating mechanism. Am J Physiol Renal Physiol 274: F413-F424, 1998.
42. Weinstein AM. A mathematical model of rat collecting duct. I. Flow effects on transport and urinary acidification. Am J Physiol Renal Physiol 283: F1237-F1251, 2002.
43. Wexler AS, Kalaba RE, Marsh DJ. Passive, one-dimensional countercurrent models do not simulate hypertonic urine formulation. Am J Physiol Renal Fluid Electrolyte Physiol 251: F358-F378, 1986.
44. Wexler AS, Kalaba RE, Marsh DJ. Three-dimensional anatomy and renal concentrating mechanism. I. Modeling results. Am J Physiol Renal Fluid Electrolyte Physiol 260: F368-F383, 1991.
45. Zerbe R, Robertson GL. Osmoregulation of thirst and vasopressin secretion in human subjects: effects of various solutes. Am J Physiol Endocrinol Metab 244: E607-E614, 1983.
46. Zhai XY, Fenton RA, Andreasen A, Thomsen JS, Christensen EI. Aquaporin-1 is not expressed in descending thin limbs of short-looped nephrons. J Am Soc Nephrol 18: 2937-2944, 2007.