메뉴 건너뛰기




Volumn 29, Issue 1, 2012, Pages 67-84

Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma

Author keywords

Development of epithelial tumours; Formation of mutant acini; Immersed boundary method; Morphology classification; Robustness; Self organization; Single cell based models

Indexed keywords

CELLS; COMPUTATION THEORY; COMPUTATIONAL METHODS; CYTOLOGY; DISEASES; MORPHOLOGY; TURBULENT FLOW;

EID: 84858191526     PISSN: 14778599     EISSN: 14778602     Source Type: Journal    
DOI: 10.1093/imammb/dqq021     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 25144494216 scopus 로고    scopus 로고
    • A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion
    • ANDERSON, A. R. A. (2005) A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. Math. Med. Biol., 22, 163-186.
    • (2005) Math. Med. Biol. , vol.22 , pp. 163-186
    • Anderson, A.R.A.1
  • 2
    • 33749069471 scopus 로고    scopus 로고
    • A continuum approach to modelling cell-cell adhesion
    • ARMSTRONG, N. J., PAINTER, K. J. & SHERRATT, J. A. (2006) A continuum approach to modelling cell-cell adhesion. J. Theor. Biol., 243, 98-113.
    • (2006) J. Theor. Biol. , vol.243 , pp. 98-113
    • Armstrong, N.J.1    Painter, K.J.2    Sherratt, J.A.3
  • 3
    • 0030431867 scopus 로고    scopus 로고
    • Modelling the role of cell-cell adhesion in the growth and development of carcinoma
    • BYRNE, H. M. & CHAPLAIN, M. (1996) Modelling the role of cell-cell adhesion in the growth and development of carcinoma. Math. Comput. Model., 24, 1-17.
    • (1996) Math. Comput. Model. , vol.24 , pp. 1-17
    • Byrne, H.M.1    Chaplain, M.2
  • 4
    • 0037124109 scopus 로고    scopus 로고
    • Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini
    • CHEN, X., EDWARDS, J. A. S., LOGSDON, C. D., ERNST, S. A. & WILLIAMS, J. A. (2002) Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini. J. Biol. Chem., 277, 18002-18009.
    • (2002) J. Biol. Chem. , vol.277 , pp. 18002-18009
    • Chen, X.1    Edwards, J.A.S.2    Logsdon, C.D.3    Ernst, S.A.4    Williams, J.A.5
  • 5
    • 77649210771 scopus 로고    scopus 로고
    • Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells
    • CIRIT, M., KRAJCOVIC, M., CHOI, C. K., WELF, E. S., HOROWITZ, A. F. & HAUGH, J. M. (2010) Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells. PLoS Comput. Biol., 6, e1000688.
    • (2010) PLoS Comput. Biol. , vol.6
    • Cirit, M.1    Krajcovic, M.2    Choi, C.K.3    Welf, E.S.4    Horowitz, A.F.5    Haugh, J.M.6
  • 6
    • 75849133597 scopus 로고    scopus 로고
    • Multiscale modelling of cellular systems in biology
    • DALLON, J. C. (2010) Multiscale modelling of cellular systems in biology. Curr. Opin. Colloid Interface Sci., 15, 24-31.
    • (2010) Curr. Opin. Colloid Interface Sci. , vol.15 , pp. 24-31
    • Dallon, J.C.1
  • 7
    • 65249180097 scopus 로고    scopus 로고
    • Using a mathematical model of cadherin-based adhesion to understand the function of the actin cytoskeleton
    • DALLON, J. C., NEWREN, E. & HANSEN, M. D. H. (2009) Using a mathematical model of cadherin-based adhesion to understand the function of the actin cytoskeleton. Phys. Rev. E, 79, 031918.
    • (2009) Phys. Rev. E , vol.79 , pp. 031918
    • Dallon, J.C.1    Newren, E.2    Hansen, M.D.H.3
  • 8
    • 25444443688 scopus 로고    scopus 로고
    • Modeling glandular epithelial cancers in three-dimensional cultures
    • DEBNATH, J. & BRUGGE, J. S. (2005) Modeling glandular epithelial cancers in three-dimensional cultures. Nat. Rev. Cancer, 5, 675-688.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 9
    • 0037020196 scopus 로고    scopus 로고
    • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    • DEBNATH, J., MILLS, K. R., COLLINS, N. L., REGINATO, M. J., MUTHUSWAMY, S. K. & BRUGGE, J. S. (2002) The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell, 111, 29-40.
    • (2002) Cell , vol.111 , pp. 29-40
    • Debnath, J.1    Mills, K.R.2    Collins, N.L.3    Reginato, M.J.4    Muthuswamy, S.K.5    Brugge, J.S.6
  • 10
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • DEBNATH, J., MUTHUSWAMY, S. K. & BRUGGE, J. S. (2003) Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods, 30, 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 11
    • 0022510406 scopus 로고
    • Cell motion, contractile networks, and the physics of interpenetrating reactive flow
    • DEMBO, M. & HARLOW, F. (1986) Cell motion, contractile networks, and the physics of interpenetrating reactive flow. Biophys. J., 50, 109-121.
    • (1986) Biophys. J. , vol.50 , pp. 109-121
    • Dembo, M.1    Harlow, F.2
  • 12
    • 79960289873 scopus 로고    scopus 로고
    • Lattice-gas cellular automata modeling of developing cell systems
    • (A. Anderson, M. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser
    • DEUTSCH, A. (2007) Lattice-gas cellular automata modeling of developing cell systems. Single-Cell-Based Models in Biology and Medicine (A. Anderson, M. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser, pp. 29-51.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 29-51
    • Deutsch, A.1
  • 13
    • 67651112587 scopus 로고    scopus 로고
    • A single-cell-based model of multicellular growth using the immersed boundary method
    • DILLON, R. H., OWEN, M. & PAINTER, K. (2008) A single-cell-based model of multicellular growth using the immersed boundary method. AMS Contemp. Math., 466, 1-15.
    • (2008) AMS Contemp. Math. , vol.466 , pp. 1-15
    • Dillon, R.H.1    Owen, M.2    Painter, K.3
  • 14
    • 53649108148 scopus 로고    scopus 로고
    • Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling
    • DOW, L. E., ELSUM, I. A., KING, C. L., KINROSS, K. M., RICHARDSON, H. E. & HUMBERT, P. O. (2008) Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. Oncogene, 27, 5988-6001.
    • (2008) Oncogene , vol.27 , pp. 5988-6001
    • Dow, L.E.1    Elsum, I.A.2    King, C.L.3    Kinross, K.M.4    Richardson, H.E.5    Humbert, P.O.6
  • 15
    • 26944481103 scopus 로고    scopus 로고
    • A single-cell-based model of tumor growth in vitro: monolayers and spheroids
    • DRASDO, D. & HOEHME, S. (2005) A single-cell-based model of tumor growth in vitro: monolayers and spheroids. Phys. Biol., 2, 133-147.
    • (2005) Phys. Biol. , vol.2 , pp. 133-147
    • Drasdo, D.1    Hoehme, S.2
  • 16
    • 36048988253 scopus 로고    scopus 로고
    • Individual cell-based models of tumor-environment interactions: multiple effects of CD97 on tumor invasion
    • GALLE, J., SITTIG, D., HANISCH, I., WOBUS, M., WANDEL, E., LOEFFLER, M. & AUST, G. (2006) Individual cell-based models of tumor-environment interactions: multiple effects of CD97 on tumor invasion. Am. J. Pathol., 169, 1802-1811.
    • (2006) Am. J. Pathol. , vol.169 , pp. 1802-1811
    • Galle, J.1    Sittig, D.2    Hanisch, I.3    Wobus, M.4    Wandel, E.5    Loeffler, M.6    Aust, G.7
  • 17
    • 70449703290 scopus 로고    scopus 로고
    • Defining the role of laminin-332 in carcinoma
    • GUESS, C. M. & QUARANTA, V. (2009) Defining the role of laminin-332 in carcinoma. Matrix Biol., 28, 445-455.
    • (2009) Matrix Biol. , vol.28 , pp. 445-455
    • Guess, C.M.1    Quaranta, V.2
  • 18
    • 0030056968 scopus 로고    scopus 로고
    • Cell adhesion: the molecular basis of tissue architecture and morphogenesis
    • GUMBINER, B. M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell, 84, 345-357.
    • (1996) Cell , vol.84 , pp. 345-357
    • Gumbiner, B.M.1
  • 19
    • 67650151006 scopus 로고    scopus 로고
    • Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling
    • INOKUCHI, J., LAU, A., TYSON, D. R. & ORNSTEIN, D. K. (2009) Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling. Carcinogenesis, 30, 1082-1088.
    • (2009) Carcinogenesis , vol.30 , pp. 1082-1088
    • Inokuchi, J.1    Lau, A.2    Tyson, D.R.3    Ornstein, D.K.4
  • 20
    • 0035955332 scopus 로고    scopus 로고
    • Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells
    • JUNG, Y. S., KIM, K. S., KIM, K. D., LIM, J. S., KIM, J. W. & KIM, E. (2001) Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells. Biochem. Biophys. Res. Commun., 288, 420-426.
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 420-426
    • Jung, Y.S.1    Kim, K.S.2    Kim, K.D.3    Lim, J.S.4    Kim, J.W.5    Kim, E.6
  • 21
    • 76349087592 scopus 로고    scopus 로고
    • A computational approach to resolve cell level contributions to early glandular epithelial cancer progression
    • KIM, S. H. J., DEBNATH, J., MOSTOV, K., PARK, S. & HUNT, C. A. (2009) A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst. Biol., 3, 122.
    • (2009) BMC Syst. Biol. , vol.3 , pp. 122
    • Kim, S.H.J.1    Debnath, J.2    Mostov, K.3    Park, S.4    Hunt, C.A.5
  • 22
    • 1542619848 scopus 로고    scopus 로고
    • Cancer as a robust system: implications for anticancer therapy
    • KITANO, H. (2004) Cancer as a robust system: implications for anticancer therapy. Nat. Rev. Cancer, 4, 227-235.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 227-235
    • Kitano, H.1
  • 23
    • 0036973401 scopus 로고    scopus 로고
    • Mechanical assessment by magnetocytometry of the cytosolic and cortical cytoskeletal compartments in adherent epithelial cells
    • LAURENT, V. M., PLANUS, E., FODIL, R. & ISABEY, D. (2003) Mechanical assessment by magnetocytometry of the cytosolic and cortical cytoskeletal compartments in adherent epithelial cells. Biorheology, 40, 235-240.
    • (2003) Biorheology , vol.40 , pp. 235-240
    • Laurent, V.M.1    Planus, E.2    Fodil, R.3    Isabey, D.4
  • 24
    • 25144441017 scopus 로고    scopus 로고
    • Proliferation and polarity in breast cancer: untying the Gordian knot
    • LIU, H., RADISKY, D. C. & BISSELL, M. J. (2005) Proliferation and polarity in breast cancer: untying the Gordian knot. Cell Cycle, 4, 646-649.
    • (2005) Cell Cycle , vol.4 , pp. 646-649
    • Liu, H.1    Radisky, D.C.2    Bissell, M.J.3
  • 25
  • 26
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • MUTHUSWAMY, S. K., LI, D., LELIEVRE, S., BISSELL, M. J. & BRUGGE, J. S. (2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol., 3, 785-795.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 785-795
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 27
    • 23744515305 scopus 로고    scopus 로고
    • Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
    • NELSON, C. M. & BISSELL, M. J. (2005) Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol., 15, 342-352.
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 342-352
    • Nelson, C.M.1    Bissell, M.J.2
  • 28
    • 39749170960 scopus 로고    scopus 로고
    • Modeling multicellular structures using the subcellular element model
    • (A. R. A. Anderson, M. A. J. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser
    • NEWMAN, T. J. (2007) Modeling multicellular structures using the subcellular element model. Single-Cell-Based Models in Biology and Medicine (A. R. A. Anderson, M. A. J. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser, pp. 221-239.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 221-239
    • Newman, T.J.1
  • 29
    • 77649337154 scopus 로고    scopus 로고
    • A 2D mechanistic model of breast ductal carcinoma in situ (DCIS) morphology and progression
    • NORTON, K.-A., WININGER, M., BHANOT, G., GANESAN, S., BARNARD, N. & SHINBROT, T. (2010) A 2D mechanistic model of breast ductal carcinoma in situ (DCIS) morphology and progression. J. Theor. Biol., 263, 393-406.
    • (2010) J. Theor. Biol. , vol.263 , pp. 393-406
    • Norton, K.-A.1    Wininger, M.2    Bhanot, G.3    Ganesan, S.4    Barnard, N.5    Shinbrot, T.6
  • 30
    • 74549222971 scopus 로고    scopus 로고
    • Integrin clustering is driven by mechanical resistance from glycocalyx and the substrate
    • PASZEK, M. J., BOETTIGER, D., WEAVER, V. M. & HAMMER, D. A. (2009) Integrin clustering is driven by mechanical resistance from glycocalyx and the substrate. PLoS Comput. Biol., 5, e1000604.
    • (2009) PLoS Comput. Biol. , vol.5
    • Paszek, M.J.1    Boettiger, D.2    Weaver, V.M.3    Hammer, D.A.4
  • 31
    • 33751544551 scopus 로고    scopus 로고
    • The immersed boundary method
    • PESKIN, C. S. (2002) The immersed boundary method. Acta Numer., 11, 479-517.
    • (2002) Acta Numer , vol.11 , pp. 479-517
    • Peskin, C.S.1
  • 32
    • 46749151795 scopus 로고    scopus 로고
    • Modeling the influence of the E-cadherin-β-catenin pathway in cancer cell invasion: a multiscale approach
    • RAMIS-CONDE, I., DRASDO, D., ANDERSON, A. & CHAPLAIN, M. (2008) Modeling the influence of the E-cadherin-β-catenin pathway in cancer cell invasion: a multiscale approach. Biophys. J., 95, 155-165.
    • (2008) Biophys. J. , vol.95 , pp. 155-165
    • Ramis-Conde, I.1    Drasdo, D.2    Anderson, A.3    Chaplain, M.4
  • 34
    • 34248638171 scopus 로고    scopus 로고
    • An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development
    • REJNIAK, K. A. (2007a) An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development. J. Theor. Biol., 247, 186-204.
    • (2007) J. Theor. Biol. , vol.247 , pp. 186-204
    • Rejniak, K.A.1
  • 35
    • 58349101184 scopus 로고    scopus 로고
    • Modelling the development of complex tissues using individual viscoelastic cells
    • (A. R. A. Anderson, M. A. J. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser
    • REJNIAK, K. A. (2007b) Modelling the development of complex tissues using individual viscoelastic cells. Single-Cell-Based Models in Biology and Medicine (A. R. A. Anderson, M. A. J. Chaplain & K. A. Rejniak eds). Basel, Switzerland: Birkhauser, pp. 301-323.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 301-323
    • Rejniak, K.A.1
  • 36
    • 41049094948 scopus 로고    scopus 로고
    • A computational study of the development of epithelial acini. I. Sufficient conditions for the formation of a hollow structure
    • REJNIAK, K. A. & ANDERSON, A. R. A. (2008a) A computational study of the development of epithelial acini. I. Sufficient conditions for the formation of a hollow structure. Bull. Math. Biol., 70, 677-712.
    • (2008) Bull. Math. Biol. , vol.70 , pp. 677-712
    • Rejniak, K.A.1    Anderson, A.R.A.2
  • 37
    • 47349093126 scopus 로고    scopus 로고
    • A computational study of the development of epithelial acini. II. Necessary conditions for structure and lumen stability
    • REJNIAK, K. A. & ANDERSON, A. R. A. (2008b) A computational study of the development of epithelial acini. II. Necessary conditions for structure and lumen stability. Bull. Math. Biol., 70, 1450-1479.
    • (2008) Bull. Math. Biol. , vol.70 , pp. 1450-1479
    • Rejniak, K.A.1    Anderson, A.R.A.2
  • 38
    • 34547099095 scopus 로고    scopus 로고
    • A single cell based model of the ductal tumour microarchitecture
    • REJNIAK, K. A. & DILLON, R. H. (2007) A single cell based model of the ductal tumour microarchitecture. Comput. Math. Methods Med., 8, 51-69.
    • (2007) Comput. Math. Methods Med. , vol.8 , pp. 51-69
    • Rejniak, K.A.1    Dillon, R.H.2
  • 40
    • 42449116644 scopus 로고    scopus 로고
    • Modeling cell rheology with the subcellular element model
    • SANDERSIUS, S. A. & NEWMAN, T. J. (2008) Modeling cell rheology with the subcellular element model. Phys. Biol., 5, e015002.
    • (2008) Phys. Biol. , vol.5
    • Sandersius, S.A.1    Newman, T.J.2
  • 43
    • 35648948933 scopus 로고    scopus 로고
    • Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium
    • TYSON, D. R., INOKUCHI, J., TSUNODA, T., LAU, A. & ORNSTEIN, D. K. (2007) Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium. Prostate, 67, 1601-1613.
    • (2007) Prostate , vol.67 , pp. 1601-1613
    • Tyson, D.R.1    Inokuchi, J.2    Tsunoda, T.3    Lau, A.4    Ornstein, D.K.5
  • 45
    • 0025023525 scopus 로고
    • Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts
    • WANG, A. Z., OJAKIAN, G. K. & NELSON, W. J. (1990a) Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts. J. Cell Sci., 95, 137-151.
    • (1990) J. Cell Sci. , vol.95 , pp. 137-151
    • Wang, A.Z.1    Ojakian, G.K.2    Nelson, W.J.3
  • 46
    • 0025191452 scopus 로고
    • Steps in the morphogenesis of a polarized epithelium. II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts
    • WANG, A. Z., OJAKIAN, G. K. & NELSON, W. J. (1990b) Steps in the morphogenesis of a polarized epithelium. II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts. J. Cell Sci., 95, 153-165.
    • (1990) J. Cell Sci. , vol.95 , pp. 153-165
    • Wang, A.Z.1    Ojakian, G.K.2    Nelson, W.J.3
  • 47
    • 33745727112 scopus 로고    scopus 로고
    • HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    • WANG, S. E., NARASANNA, A., PEREZ-TORRES, M., XIANG, B., WU, F. Y., YANG, S., CARPENTER, G., GAZDAR, A. F., MUTHUSWAMY, S. K. & ARTEAGA, C. L. (2006) HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10, 25-38.
    • (2006) Cancer Cell , vol.10 , pp. 25-38
    • Wang, S.E.1    Narasanna, A.2    Perez-Torres, M.3    Xiang, B.4    Wu, F.Y.5    Yang, S.6    Carpenter, G.7    Gazdar, A.F.8    Muthuswamy, S.K.9    Arteaga, C.L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.