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Volumn 22, Issue 2, 2012, Pages 70-81

Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families

Author keywords

attention; NRG1; rs10503929

Indexed keywords

GLUTAMIC ACID; NEU DIFFERENTIATION FACTOR;

EID: 84858153976     PISSN: 09558829     EISSN: 14735873     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32834f352c     Document Type: Article
Times cited : (18)

References (58)
  • 1
    • 0033909546 scopus 로고    scopus 로고
    • A general test of association for quantitative traits in nuclear families
    • DOI 10.1086/302698
    • Abecasis GR, Cardon LR, Cookson WO (2000). A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66: 279-292. (Pubitemid 30481489)
    • (2000) American Journal of Human Genetics , vol.66 , Issue.1 , pp. 279-292
    • Abecasis, G.R.1    Cardon, L.R.2    Cookson, W.O.C.3
  • 3
    • 0031966959 scopus 로고    scopus 로고
    • Multipoint quantitative-trait linkage analysis in general pedigrees
    • DOI 10.1086/301844
    • Almasy L, Blangero J (1998). Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211. (Pubitemid 28199022)
    • (1998) American Journal of Human Genetics , vol.62 , Issue.5 , pp. 1198-1211
    • Almasy, L.1    Blangero, J.2
  • 4
    • 51349141278 scopus 로고    scopus 로고
    • A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes
    • Almasy L, Gur RC, Haack K, Cole SA, Calkins ME, Peralta JM, et al. (2008). A genome screen for quantitative trait loci influencing schizophrenia and neurocognitive phenotypes. Am J Psychiatry 165:1185-1192.
    • (2008) Am J Psychiatry , vol.165 , pp. 1185-1192
    • Almasy, L.1    Gur, R.C.2    Haack, K.3    Cole, S.A.4    Calkins, M.E.5    Peralta, J.M.6
  • 6
    • 20844439028 scopus 로고    scopus 로고
    • A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia
    • Buchanan RW, Davis M, Goff D, Green MF, Keefe RS, Leon AC, et al. (2005). A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia. Schizophr Bull 31:5-19.
    • (2005) Schizophr Bull , vol.31 , pp. 5-19
    • Buchanan, R.W.1    Davis, M.2    Goff, D.3    Green, M.F.4    Keefe, R.S.5    Leon, A.C.6
  • 7
    • 33751224822 scopus 로고
    • Convergent and discriminant validation by the multitrait-multimethod matrix
    • Campbell DT, Fiske DW (1959). Convergent and discriminant validation by the multitrait-multimethod matrix. Psychol Bull 56:81-105.
    • (1959) Psychol Bull , vol.56 , pp. 81-105
    • Campbell, D.T.1    Fiske, D.W.2
  • 9
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics
    • DOI 10.1002/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U
    • Cardno AG, Gottesman II (2000). Twin studies of schizophrenia: from bow-andarrow concordances to star wars Mx and functional genomics. Am J Med Genet 97:12-17. (Pubitemid 30257322)
    • (2000) American Journal of Medical Genetics - Seminars in Medical Genetics , vol.97 , Issue.1 , pp. 12-17
    • Cardno, A.G.1    Gottesman, I.I.2
  • 10
    • 77949797723 scopus 로고    scopus 로고
    • Aspects of observing and claiming allele flips in association studies
    • Clarke GM, Cardon LR (2010). Aspects of observing and claiming allele flips in association studies. Genet Epidemiol 34:266-274.
    • (2010) Genet Epidemiol , vol.34 , pp. 266-274
    • Clarke, G.M.1    Cardon, L.R.2
  • 11
    • 36749079336 scopus 로고    scopus 로고
    • So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests
    • DOI 10.1086/522036
    • Conneely KN, Boehnke M (2007). So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet 81:1158-1168. (Pubitemid 350211447)
    • (2007) American Journal of Human Genetics , vol.81 , Issue.6 , pp. 1158-1168
    • Conneely, K.N.1    Boehnke, M.2
  • 13
    • 31544434767 scopus 로고    scopus 로고
    • Neuregulin 1 (NRG1) and schizophrenia: Analysis of a US family sample and the evidence in the balance
    • Duan J, Martinez M, Sanders AR, Hou C, Krasner AJ, Schwartz DB, et al. (2005). Neuregulin 1 (NRG1) and schizophrenia: analysis of a US family sample and the evidence in the balance. Psychol Med 35:1599-1610.
    • (2005) Psychol Med , vol.35 , pp. 1599-1610
    • Duan, J.1    Martinez, M.2    Sanders, A.R.3    Hou, C.4    Krasner, A.J.5    Schwartz, D.B.6
  • 14
    • 0033366671 scopus 로고    scopus 로고
    • Combined linkage and association sib-pair analysis for quantitative traits
    • Fulker DW, Cherny SS, Sham PC, Hewitt JK (1999). Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet 64: 259-267.
    • (1999) Am J Hum Genet , vol.64 , pp. 259-267
    • Fulker, D.W.1    Cherny, S.S.2    Sham, P.C.3    Hewitt, J.K.4
  • 15
    • 0030856895 scopus 로고    scopus 로고
    • Reliability, performance characteristics, construct validity, and an initial clinical application of a Visual Object Learning Test (VOLT)
    • DOI 10.1037/0894-4105.11.4.602
    • Glahn DC, Gur RC, Ragland JD, Censits DM, Gur RE (1997). Reliability, performance characteristics, construct validity, and an initial clinical application of a visual object learning test (VOLT). Neuropsychology 11:602-612. (Pubitemid 27459767)
    • (1997) Neuropsychology , vol.11 , Issue.4 , pp. 602-612
    • Glahn, D.C.1    Gur, R.C.2    Daniel, R.J.3    Censits, D.M.4    Gur, R.E.5
  • 16
    • 2342492982 scopus 로고    scopus 로고
    • Neurocognitive functioning in patients with schizophrenia: An overview
    • Davis KL, Charney D, Coyle JT, Nemeroff C, editors. New York: Lippincott Williams & Wilkins
    • Goldberg TE, Green MF (2002). Neurocognitive functioning in patients with schizophrenia: an overview. In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: the fifth generation of progress. New York: Lippincott Williams & Wilkins; pp. 657-669.
    • (2002) Neuropsychopharmacology: The Fifth Generation of Progress , pp. 657-669
    • Goldberg, T.E.1    Green, M.F.2
  • 17
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • DOI 10.1176/appi.ajp.160.4.636
    • Gottesman II, Gould TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645. (Pubitemid 41079594)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.4 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 19
    • 0027661552 scopus 로고
    • Effects of memory processing on regional brain activation: Cerebral blood flow in normal subjects
    • Gur RC, Jaggi JL, Ragland JD, Resnick SM, Shtasel D, Muenz L, et al. (1993). Effects of memory processing on regional brain activation: cerebral blood flow in normal subjects. Int J Neurosci 72:31-44.
    • (1993) Int J Neurosci , vol.72 , pp. 31-44
    • Gur, R.C.1    Jaggi, J.L.2    Ragland, J.D.3    Resnick, S.M.4    Shtasel, D.5    Muenz, L.6
  • 22
    • 77249123395 scopus 로고    scopus 로고
    • A cognitive neuroscience based computerized battery for efficient measurement of individual differences: Standardization and initial construct validation
    • Gur RC, Richard J, Hughett P, Calkins M, Macy L, Bilker W, et al. (2010). A cognitive neuroscience based computerized battery for efficient measurement of individual differences: standardization and initial construct validation. J Neurosci Methods 187:254-262.
    • (2010) J Neurosci Methods , vol.187 , pp. 254-262
    • Gur, R.C.1    Richard, J.2    Hughett, P.3    Calkins, M.4    Macy, L.5    Bilker, W.6
  • 23
    • 33645238221 scopus 로고    scopus 로고
    • Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures
    • Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, et al. (2006). Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures. Schizophr Bull 32:279-287.
    • (2006) Schizophr Bull , vol.32 , pp. 279-287
    • Gur, R.E.1    Kohler, C.G.2    Ragland, J.D.3    Siegel, S.J.4    Lesko, K.5    Bilker, W.B.6
  • 27
    • 33745684066 scopus 로고    scopus 로고
    • Neuregulin 1 and schizophrenia: Genetics, gene expression, and neurobiology
    • Harrison PJ, Law AJ (2006). Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60:132-140.
    • (2006) Biol Psychiatry , vol.60 , pp. 132-140
    • Harrison, P.J.1    Law, A.J.2
  • 28
    • 12344327212 scopus 로고    scopus 로고
    • Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
    • DOI 10.1038/sj.mp.4001558
    • Harrison PJ, Weinberger DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40-68. (Pubitemid 40139588)
    • (2005) Molecular Psychiatry , vol.10 , Issue.1 , pp. 40-68
    • Harrison, P.J.1    Weinberger, D.R.2
  • 29
    • 30344463185 scopus 로고    scopus 로고
    • The quantitative trait linkage disequilibrium test: A more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification
    • Havill LM, Dyer TD, Richardson DK, Mahaney MC, Blangero J (2005). The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification. BMC Genet 6 (Suppl 1):S91.
    • (2005) BMC Genet , vol.6 , Issue.SUPPL. 1
    • Havill, L.M.1    Dyer, T.D.2    Richardson, D.K.3    Mahaney, M.C.4    Blangero, J.5
  • 30
    • 0031281250 scopus 로고    scopus 로고
    • Parsing schizophrenia with neurocognitive tests: Evidence of stability and validity
    • DOI 10.1006/brcg.1997.0938
    • Heinrichs RW, Ruttan L, Zakzanis KK, Case D (1997). Parsing schizophrenia with neurocognitive tests: evidence of stability and validity. Brain Cogn 35: 207-224. (Pubitemid 27494913)
    • (1997) Brain and Cognition , vol.35 , Issue.2 , pp. 207-224
    • Heinrichs, R.W.1    Ruttan, L.2    Zakzanis, K.K.3    Case, D.4
  • 31
    • 3242759878 scopus 로고    scopus 로고
    • Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia
    • DOI 10.1016/j.neulet.2004.05.027, PII S030439400400607X
    • Hong CJ, Huo SJ, Liao DL, Lee K, Wu JY, Tsai SJ (2004). Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia. Neurosci Lett 366:158-161. (Pubitemid 38970147)
    • (2004) Neuroscience Letters , vol.366 , Issue.2 , pp. 158-161
    • Hong, C.-J.1    Huo, S.-J.2    Liao, D.-L.3    Lee, K.4    Wu, J.-Y.5    Tsai, S.-J.6
  • 32
    • 66949163644 scopus 로고    scopus 로고
    • Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals
    • Kircher T, Krug A, Markov V,Whitney C, Krach S, Zerres K, et al. (2009). Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals. Hum Brain Mapp 30:3406-3416.
    • (2009) Hum Brain Mapp , vol.30 , pp. 3406-3416
    • Kircher, T.1    Krug, A.2    Markov, V.3    Whitney, C.4    Krach, S.5    Zerres, K.6
  • 33
    • 60649091360 scopus 로고    scopus 로고
    • Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas
    • Kircher T, Thienel R, Wagner M, Reske M, Habel U, Kellermann T, et al. (2008). Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas. Eur Arch Psychiatry Clin Neurosci 259:72-79.
    • (2008) Eur Arch Psychiatry Clin Neurosci , vol.259 , pp. 72-79
    • Kircher, T.1    Thienel, R.2    Wagner, M.3    Reske, M.4    Habel, U.5    Kellermann, T.6
  • 34
    • 55349100175 scopus 로고    scopus 로고
    • Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals
    • Krug A, Markov V, Eggermann T, Krach S, Zerres K, Stocker T, et al. (2008). Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals. Neuroimage 42:1569-1576.
    • (2008) Neuroimage , vol.42 , pp. 1569-1576
    • Krug, A.1    Markov, V.2    Eggermann, T.3    Krach, S.4    Zerres, K.5    Stocker, T.6
  • 35
    • 0035970651 scopus 로고    scopus 로고
    • Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia
    • DOI 10.1016/S0920-9964(00)00060-8, PII S0920996400000608
    • Kurtz MM, Ragland JD, Bilker W, Gur RC, Gur RE (2001). Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia. Schizophr Res 48: 307-316. (Pubitemid 32274325)
    • (2001) Schizophrenia Research , vol.48 , Issue.2-3 , pp. 307-316
    • Kurtz, M.M.1    Ragland, J.D.2    Bilker, W.3    Gur, R.C.4    Gur, R.E.5
  • 36
    • 1542328900 scopus 로고    scopus 로고
    • The Penn Conditional Exclusion Test: A new measure of executive-function with alternate forms for repeat administration
    • DOI 10.1016/S0887-6177(03)00003-9, PII S0887617703000039
    • Kurtz MM, Ragland JD, Moberg PJ, Gur RC (2004). The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms of repeat administration. Arch Clin Neuropsychol 19:191-201. (Pubitemid 38316870)
    • (2004) Archives of Clinical Neuropsychology , vol.19 , Issue.2 , pp. 191-201
    • Kurtz, M.M.1    Ragland, J.D.2    Moberg, P.J.3    Gur, R.C.4
  • 37
    • 33745616542 scopus 로고    scopus 로고
    • Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia
    • DOI 10.1093/hmg/ddl122
    • Li D, Collier DA, He L (2006). Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 15:1995-2002. (Pubitemid 43983273)
    • (2006) Human Molecular Genetics , vol.15 , Issue.12 , pp. 1995-2002
    • Li, D.1    Collier, D.A.2    He, L.3
  • 39
    • 27244437994 scopus 로고    scopus 로고
    • Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents
    • Lin HF, Liu YL, Liu CM, Hung SI, Hwu HG, Chen WJ (2005). Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents. Psychol Med 35:1589-1598.
    • (2005) Psychol Med , vol.35 , pp. 1589-1598
    • Lin, H.F.1    Liu, Y.L.2    Liu, C.M.3    Hung, S.I.4    Hwu, H.G.5    Chen, W.J.6
  • 42
    • 0032231941 scopus 로고    scopus 로고
    • PedCheck: A program for identification of genotype incompatibilities in linkage analysis
    • O'Connell JR, Weeks DE (1998). PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266.
    • (1998) Am J Hum Genet , vol.63 , pp. 259-266
    • O'Connell, J.R.1    Weeks, D.E.2
  • 44
    • 84858159455 scopus 로고    scopus 로고
    • Schizophrenia: Study of a genetically complex phenotype
    • Jones BC, Mormede P, editors. 2nd ed. Boca Raton, FL: CRC Press
    • Pogue-Geile MF, Gottesman II (2007). Schizophrenia: study of a genetically complex phenotype. In: Jones BC, Mormede P, editors. Neurobehavioral genetics: methods and applications. 2nd ed. Boca Raton, FL: CRC Press; pp. 209-226.
    • (2007) Neurobehavioral Genetics: Methods and Applications , pp. 209-226
    • Pogue-Geile, M.F.1    Gottesman, I.I.2
  • 45
    • 77957867158 scopus 로고    scopus 로고
    • Current research on the genetic causes of schizophrenia
    • Pogue-Geile MF, Yokley JL (2010). Current research on the genetic causes of schizophrenia. Curr Dir Psychol Sci 19:214-219.
    • (2010) Curr Dir Psychol Sci , vol.19 , pp. 214-219
    • Pogue-Geile, M.F.1    Yokley, J.L.2
  • 47
    • 33645759752 scopus 로고    scopus 로고
    • Schizophrenia: Do the genetics and neurobiology of neuregulin provide a pathogenesis model?
    • Scolnick EM, Petryshen T, Sklar P (2006). Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model? Harv Rev Psychiatry 14:64-77.
    • (2006) Harv Rev Psychiatry , vol.14 , pp. 64-77
    • Scolnick, E.M.1    Petryshen, T.2    Sklar, P.3
  • 48
    • 68449096727 scopus 로고    scopus 로고
    • Common variants on chromosome 6p22.1 are associated with schizophrenia
    • Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, et al. (2009). Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature 460:753-757.
    • (2009) Nature , vol.460 , pp. 753-757
    • Shi, J.1    Levinson, D.F.2    Duan, J.3    Sanders, A.R.4    Zheng, Y.5    Pe'er, I.6
  • 49
    • 30344481921 scopus 로고    scopus 로고
    • Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes
    • DOI 10.1093/schbul/sbi048
    • Snitz BE, Macdonald AW III, Carter CS (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 32:179-194. (Pubitemid 43063833)
    • (2006) Schizophrenia Bulletin , vol.32 , Issue.1 , pp. 179-194
    • Snitz, B.E.1    MacDonald III, A.W.2    Carter, C.S.3
  • 50
    • 34548499070 scopus 로고    scopus 로고
    • Impact of Schizophrenia Candidate Genes on Schizotypy and Cognitive Endophenotypes at the Population Level
    • DOI 10.1016/j.biopsych.2006.11.015, PII S0006322306014879, Molecular Mechanisms, Brain Development, and Novel Treatment Mechanisms for Schizophrenia
    • Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, et al. (2007). Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry 62: 784-792. (Pubitemid 47374644)
    • (2007) Biological Psychiatry , vol.62 , Issue.7 , pp. 784-792
    • Stefanis, N.C.1    Trikalinos, T.A.2    Avramopoulos, D.3    Smyrnis, N.4    Evdokimidis, I.5    Ntzani, E.E.6    Ioannidis, J.P.7    Stefanis, C.N.8
  • 54
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a Complex Trait: Evidence from a Meta-analysis of Twin Studies
    • DOI 10.1001/archpsyc.60.12.1187
    • Sullivan PF, Kendler KS, Neale MC (2003). Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60:1187-1192. (Pubitemid 37494071)
    • (2003) Archives of General Psychiatry , vol.60 , Issue.12 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 55
    • 20844439711 scopus 로고    scopus 로고
    • Indicators of genetic liability to schizophrenia: A sibling study of neuropsychological performance
    • DOI 10.1093/schbul/sbi009
    • Thompson JL,Watson JR, Steinhauer SR, Goldstein G, Pogue-Geile MF (2005). Indicators of genetic liability to schizophrenia: a sibling study of neuropsychological performance. Schizophr Bull 31:85-96. (Pubitemid 41214359)
    • (2005) Schizophrenia Bulletin , vol.31 , Issue.1 , pp. 85-96
    • Thompson, J.L.1    Watson, J.R.2    Steinhauer, S.R.3    Goldstein, G.4    Pogue-Geile, M.F.5
  • 56
    • 24344433989 scopus 로고    scopus 로고
    • Association between the neuregulin 1 gene and schizophrenia: A systematic review
    • DOI 10.1093/schbul/sbi043
    • Tosato S, Dazzan P, Collier D (2005). Association between the neuregulin 1 gene and schizophrenia: a systematic review. Schizophr Bull 31:613-617. (Pubitemid 41253313)
    • (2005) Schizophrenia Bulletin , vol.31 , Issue.3 , pp. 613-617
    • Tosato, S.1    Dazzan, P.2    Collier, D.3
  • 57
    • 0034073858 scopus 로고    scopus 로고
    • Cysteine-rich domain isoforms of the Neuregulin-1 gene are required for maintenance of peripheral synapses
    • Wolpowitz D, Mason TB, Dietrich P, Mendelsohn M, Talmage DA, Role LW (2000). Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron 25:79-91. (Pubitemid 30316512)
    • (2000) Neuron , vol.25 , Issue.1 , pp. 79-91
    • Wolpowitz, D.1    Mason, T.B.A.2    Dietrich, P.3    Mendelsohn, M.4    Talmage, D.A.5    Role, L.W.6


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