Difficulties in dopamine transporter radioligand PET analysis: The example of LBT-999 using [18F] and [11C] labelling. Part II: Metabolism studies

Nuclear Medicine and Biology

Volumn 39, Issue 3, 2012, Pages 347-359

  Peyronneau, Marie Anne ^a   Saba, Wadad ^a   Dollé, Frédéric ^a   Goutal, Sébastien ^a   Coulon, Christine ^a   Bottlaender, Michel ^a   Valette, Héric ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

18F LBT 999; DAT; P450; PET radiotracer; Radiometabolites; Tissue kinetics

Indexed keywords

CARBOXYLIC ACID F 18; CYTOCHROME P450; DOPAMINE TRANSPORTER; FLUOROBUTENALDEHDYE F 18; LBT 999; N (4 FLUOROBUT 2 ENYL) 2BETA CARBOMETHOXY 3BETA (4' TOLYL)NORTROPANE C 11; N (4 FLUOROBUT 2 ENYL) 2BETA CARBOMETHOXY 3BETA (4' TOLYL)NORTROPANE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BABOON; BIOTRANSFORMATION; BLOOD; BRAIN; CATALYSIS; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DEALKYLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROXYLATION; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLISM; NONHUMAN; OXIDATION; POSITRON EMISSION TOMOGRAPHY; RAT; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; CHROMATOGRAPHY, LIQUID; COCAINE; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUORINE RADIOISOTOPES; HUMANS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84858151757     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.09.006     Document Type: Article

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