Diabetes-impaired wound healing and altered macrophage activation: A possible pathophysiologic correlation

Wound Repair and Regeneration

Volumn 20, Issue 2, 2012, Pages 203-213

  Miao, Mingyuan ^a   Niu, Yiwen ^a   Xie, Ting ^a   Yuan, Bo ^a   Qing, Chun ^a   Lu, Shuliang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; BIOLOGICAL MARKER; CD68 ANTIGEN; GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; INTERLEUKIN 4; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; TH1 CELL; TH2 CELL; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGE ACTIVATION; MALE; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SKIN; WOUND HEALING;

EID: 84858115411     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00772.x     Document Type: Article

References (33)

1. Broughton G II, Janis JE, Attinger CE,. The basic science of wound healing. Plast Reconstr Surg 2006; 117: 12S-34S. (Pubitemid 44317769)
2. Park JE, Barbul A,. Understanding the role of immune regulation in wound healing. Am J Surg 2004; 187: 11S-16S. (Pubitemid 38625982)
3. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA,. Diabetic neuropathic foot ulcers and amputation. Wound Rep Regen 2005; 13: 230-236. (Pubitemid 40848014)
4. Fu X, Sheng Z, Cherry GW, Li Q,. Epidemiological study of chronic dermal ulcers in China. Wound Rep Regen 1998; 6: 21-27. (Pubitemid 128656987)
5. Jiang Y, Huang S, Fu X, Liu H, Ran X, Lu S, Hu D, Li Q, Zhang H, Li Y, Wang R, Xie T, Cheng B, Wang L, Liu Y, Ye X, Han C, Chen H,. Epidemiology of chronic cutaneous wounds in China. Wound Repair Regen 2011; 19: 181-188.
6. Gordon S, Taylor PR,. Monocyte and macrophage heterogeneity. Nat Rev Immunol 2005; 5: 953-964. (Pubitemid 41746764)
7. Stout RD,. Editorial: macrophage functional phenotypes: no alternatives in dermal wound healing? J Leukoc Biol 2010; 87: 19-21.
8. Gordon S,. Alternative activation of macrophages. Nat Rev Immunol 2003; 3: 23-35. (Pubitemid 37328697)
9. Schebesch C, Kodelja V, Muller C, Hakij N, Bisson S, Orfanos CE, Goerdt S,. Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro. Immunology 1997; 92: 478-486. (Pubitemid 27525219)
10. Gary Sibbald R, Woo KY,. The biology of chronic foot ulcers in persons with diabetes. Diabetes Metab Res Rev 2008; 24: S25-30. (Pubitemid 351802768)
11. Chen WY, Rogers AA,. Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds. Wound Repair Regen 2007; 15: 434-449. (Pubitemid 47087635)
12. Li J, Chen J, Kirsner R,. Pathophysiology of acute wound healing. Clin Dermatol 2007; 25: 9-18. (Pubitemid 46177460)
13. Katakura T, Miyazaki M, Kobayashi M, Herndon DN, Suzuki F,. CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages. J Immunol 2004; 172: 1407-1413. (Pubitemid 38116782)
14. Misson P, van den Brule S, Barbarin V, Lison D, Huaux F,. Markers of macrophage differentiation in experimental silicosis. J Leukoc Biol 2004; 76: 926-932. (Pubitemid 39458704)
15. Weller R,. Nitric oxide: a key mediator in cutaneous physiology. Clin Exp Dermatol 2003; 28: 511-514. (Pubitemid 37100555)
16. Reichner JS, Meszaros AJ, Louis CA, Henry WL Jr, Mastrofrancesco B, Martin BA, Albina JE,. Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds. Am J Pathol 1999; 154: 1097-1104. (Pubitemid 29169744)
17. Seno H, Miyoshi H, Brown SL, Geske MJ, Colonna M, Stappenbeck TS,. Efficient colonic mucosal wound repair requires Trem2 signaling. Proc Natl Acad Sci U S A 2009; 106: 256-261.
18. Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, Thompson RW, Cheever AW, Murray PJ, Wynn TA,. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog 2009; 5: e1000371.
19. Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA,. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J Immunol 2001; 167: 6533-6544. (Pubitemid 33081589)
20. Fairweather D, Cihakova D,. Alternatively activated macrophages in infection and autoimmunity. J Autoimmun 2009; 33: 222-230.
21. Zhang QZ, Su WR, Shi SH, Wilder-Smith P, Xiang AP, Wong A, Nguyen AL, Kwon CW, Le AD,. Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells 2010; 28: 1856-1868.
22. Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, Whitfield ML, Farber HW, Lafyatis R,. Interferon and alternative activation of macrophage/monocytes in systemic sclerosis-associated pulmonary arterial hypertension. Arthritis Rheum 2011; 63: 1718-1728.
23. Sun L, Louie MC, Vannella KM, Wilke CA, LeVine AM, Moore BB, Shanley TP,. New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis. Am J Physiol Lung Cell Mol Physiol 2011; 300: L341-353.
24. Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, Hainzl A, Schatz S, Qi Y, Schlecht A, Weiss JM, Wlaschek M, Sunderkötter C, Scharffetter-Kochanek K,. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 2011; 121: 985-997.
25. Deonarine K, Panelli MC, Stashower ME, Jin P, Smith K, Slade HB, Norwood C, Wang E, Marincola FM, Stroncek DF,. Gene expression profiling of cutaneous wound healing. J Transl Med 2007; 5: 11.
26. Daley JM, Brancato SK, Thomay AA, Reichner JS, Albina JE,. The phenotype of murine wound macrophages. J Leukoc Biol 2010; 87: 59-67.
27. Boateng JS, Matthews KH, Stevens HN, Eccleston GM,. Wound healing dressings and drug delivery systems: a review. J Pharm Sci 2008; 97: 2892-2923.
28. Abbas AK, Murphy KM, Sher A,. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787-793. (Pubitemid 26372655)
29. Shi Z, Wakil AE, Rockey DC,. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci U S A 1997; 94: 10663-10668. (Pubitemid 27430791)
30. Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM,. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 2000; 164: 6166-6173. (Pubitemid 30408793)
31. Goren I, Müller E, Schiefelbein D, Christen U, Pfeilschifter J, Mühl H, Frank S,. Systemic anti-TNF alpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol 2007; 127: 2259-2267. (Pubitemid 47258485)
32. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR,. Interleukin-10. Annu Rev Immunol 1993; 11: 165-190. (Pubitemid 23115005)
33. Watford WT, Moriguchi M, Morinobu A, O'Shea JJ,. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev 2003; 14: 361-368. (Pubitemid 37099449)