Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds

American Journal of Pathology

Volumn 154, Issue 4, 1999, Pages 1097-1104

  Reichner, Jonathan S ^a,b   Meszaros, Adriana J ^a   Louis, Claudine A ^a   Henry Jr , William L ^a   Mastrofrancesco, Balduino ^a   Martin, Barbara Anne ^a   Albina, Jorge E ^a  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; EXTRACELLULAR FLUID; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MACROPHAGE; MALE; NEUTROPHIL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; WOUND HEALING;

EID: 0032924490     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65362-X     Document Type: Article

References (16)

1. Albina JE, Mills CD, Barbul A, Thirkill CE, Henry WL Jr, Mastrofrancesco B, Caldwell MD: Arginine metabolism in wounds. Am J Physiol 1988, 254:E459-E467
2. Albina JE, Mills CD, Henry WL Jr, Caldwell MD: Temporal expression of different pathways of L-arginine metabolism in healing wounds. J Immunol 1990, 144:3877-3880
3. Albina JE, Henry WL Jr, Mastrofrancesco B, Martin B-A, Reichner JS: Macrophage activation by culture in an anoxic environment. J Immunol 1995, 155:4391-4396
4. Louis CA, Reichner JS, Henry WL Jr, Mastrofrancesco B, Gotoh T, Mori M, Albina JE: Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension. Am J Physiol 1998, 274:R775-R782
5. Schäffer MR, Tantry U, Gross SS, Wasserkrug HL, Barbul A: Nitric oxide regulates wound healing. J Surg Res 1996, 63:237-240
6. Bodenheimer HC, Faris RA, Charland C, Hixson DC: Characterization of a new monoclonal antibody to rat macrophages and Kupffer cells. Hepatology 1988, 8:1667-1672
7. Sekiya S, Gotoh S, Yamashita T, Watanabe T, Saitoh S, Sendo F: Selective depletion of rat neutrophils by in vivo administration of a monoclonal antibody. J Leukoc Biol 1990, 46:96-102
8. Albina JE, Reichner JS: Nitric oxide in inflammation and immunity. New Horizons 1995, 3:46-64
9. Miles AM, Owens MW, Milligan S, Johnson GG, Fields JZ, Ing TS, Kottapalli V, Keshavarzian A, Grisham MB: Nitric oxide synthase in circulating versus extravasated polymorphonuclear leukocytes. J Leukoc Biol 1995, 58:616-622
10. Hon WM, Chhatwal VJS, Khoo HE, Moochhala SM: Histochemical method for detecting nitric oxide synthase activity in cell cultures. Biotech Histochem 1997, 72:29-32
11. Schäffer MR, Tantry U, Van Wesep RA, Barbul A: Nitric oxide metabolism in wounds. J Surg Res 1997, 71:25-31
12. Yamasaki K, Edington HDJ, McClosky C, Tzeng E, Lizonova A, Kovesdl I, Steed DL, Billiar TR: Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998, 101:967-971
13. Albina JE, Henry WL Jr: Suppression of lymphocyte proliferation through the nitric oxide synthesizing pathway. J Surg Res 1991, 50:403-409
14. Albina JE, Abate JA, Henry WL Jr: Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogenstimulated T cell proliferation. J Immunol 1991, 147:144-148
15. Kolpakov V, Gordon D, Kulik TJ: Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ Res 1995, 76:305-309
16. Cao M, Westerhausen-Larson A, Niyibizi C, Kavalkovich K, Georgescu HI, Rizzo CF, Hebda PA, Stefanovic-Racic M, Evans CH: Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target. Biochem J 1997, 324:305-310