메뉴 건너뛰기




Volumn 63, Issue , 2012, Pages 29-39

Identification of major compounds in rat bile after oral administration of total triterpenoids of Ganoderma lucidum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry

Author keywords

Ganoderma lucidum; HPLC DAD ESI MSn; LC ESI IT TOF MS; Metabolites; Triterpenoids

Indexed keywords

12 HYDROXYGANODERIC ACID C2; 3,12,15 TRIHYDROXY 11,23 DIOXO LANOST 8 EN 26 OIC ACID; 3,7,12 TRIHYDROXY 4 (HYDROXYMETHYL) 11,15,23 TRIOXO LANOST 8 EN 26 OIC ACID; 3,7,12 TRIHYDROXY 4,4,14 TRIMETHYL 3,11 DIOXO CHOL 8 EN 24 OIC ACID; 3,7,15 TRIHYDROXY 4 (HYDROXYMETHYL) 11,23 DIOXO LANOST 8 EN 26 OIC ACID; 3,7,15 TRIHYDROXY 4,4,14 TRIMETHYL 11 OXO CHOL 8 EN 24 OIC ACID; 3BETA HYDROXY 4,4,14 TRIMETHYL 7,11,15 TRIOXO CHOL 8 EN 24 OIC ACID; 7,15 DIHYDROXY 4,4,14 TRIMETHYL 3,11 DIOXO CHOL 8 EN 24 OIC ACID; GANODERENIC ACID B; GANODERIC ACID A; GANODERIC ACID AM1; GANODERIC ACID B; GANODERIC ACID C2; GANODERIC ACID C2 3 O GLUCURONIDE; GANODERIC ACID C2 7 O GLUCURONIDE; GANODERIC ACID D; GANODERIC ACID E; GANODERIC ACID ETA; GANODERIC ACID G; GANODERIC ACID H; GANODERIC ACID K; GANODERIC ACID L; GANODERMA LUCIDUM EXTRACT; GANOLUCIDIC ACID A; LUCIDENIC ACID A; LUCIDENIC ACID C; LUCIDENIC ACID H; LUCIDENIC ACID N; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84858082567     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.01.030     Document Type: Article
Times cited : (36)

References (34)
  • 1
    • 0012811013 scopus 로고    scopus 로고
    • Beijing Medical University Press, Beijing
    • Chen Z.B. Modern Research of Ganoderma lucidum 2001, Beijing Medical University Press, Beijing, pp. 219-304. 2nd ed.
    • (2001) Modern Research of Ganoderma lucidum , pp. 219-304
    • Chen, Z.B.1
  • 2
    • 84894234338 scopus 로고    scopus 로고
    • Reishi or Ling Zhi (Ganoderma lucidum), Encyclopedia of Dietary Supplements doi:10.1081/E-EDS-120022119
    • S.P. Wasser, Reishi or Ling Zhi (Ganoderma lucidum), Encyclopedia of Dietary Supplements, 604 pp., doi:10.1081/E-EDS-120022119.
    • Wasser, S.P.1
  • 3
    • 34548163453 scopus 로고    scopus 로고
    • Research advance on triterpenoids of Ganoderma lucidum
    • Gao J.L., Yu Z.L., Li S.P., Wang Y.T. Research advance on triterpenoids of Ganoderma lucidum. Edible Fungi China 2004, 24:6-11.
    • (2004) Edible Fungi China , vol.24 , pp. 6-11
    • Gao, J.L.1    Yu, Z.L.2    Li, S.P.3    Wang, Y.T.4
  • 4
    • 77953988178 scopus 로고    scopus 로고
    • Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    • Thyagarajan A., Jedinak A., Nguyen H., Terry C., Baldridge L.A., Jiang J.H., Sliva D. Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr. Cancer 2010, 62:630-640.
    • (2010) Nutr. Cancer , vol.62 , pp. 630-640
    • Thyagarajan, A.1    Jedinak, A.2    Nguyen, H.3    Terry, C.4    Baldridge, L.A.5    Jiang, J.H.6    Sliva, D.7
  • 6
    • 0031795507 scopus 로고    scopus 로고
    • Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease
    • Min B.S., Nakamura N., Miyashiro H., Bae K.W., Hattori M. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull. 1998, 46:1607-1612.
    • (1998) Chem. Pharm. Bull. , vol.46 , pp. 1607-1612
    • Min, B.S.1    Nakamura, N.2    Miyashiro, H.3    Bae, K.W.4    Hattori, M.5
  • 8
    • 70249137176 scopus 로고    scopus 로고
    • Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
    • Dudhgaonkar S., Thyagarajan A., Sliva D. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Int. Immunopharmacol. 2009, 9:1272-1280.
    • (2009) Int. Immunopharmacol. , vol.9 , pp. 1272-1280
    • Dudhgaonkar, S.1    Thyagarajan, A.2    Sliva, D.3
  • 10
    • 0035668974 scopus 로고    scopus 로고
    • Anticomplement activity of terpenoids from the spores of Ganoderma lucidum
    • Min B.S., Gao J.J., Hattori M., Lee H.K., Kim Y.H. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001, 67:811-814.
    • (2001) Planta Med. , vol.67 , pp. 811-814
    • Min, B.S.1    Gao, J.J.2    Hattori, M.3    Lee, H.K.4    Kim, Y.H.5
  • 14
    • 0042640612 scopus 로고    scopus 로고
    • Effects of triterpenoids from Ganoderma lucidum (Leyss. ex Fr.) Karst on three different experimental liver injury models in mice
    • Wang M.Y., Liu Q., Che Q.M., Lin Z.B. Effects of triterpenoids from Ganoderma lucidum (Leyss. ex Fr.) Karst on three different experimental liver injury models in mice. Acta Pharm. Sin. 2000, 35:326-329.
    • (2000) Acta Pharm. Sin. , vol.35 , pp. 326-329
    • Wang, M.Y.1    Liu, Q.2    Che, Q.M.3    Lin, Z.B.4
  • 15
    • 33646415921 scopus 로고    scopus 로고
    • Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography
    • Wang X.M., Yang M., Guan S.H., Liu R.X., Xia J.M., Bi K.S., Guo D.A. Quantitative determination of six major triterpenoids in Ganoderma lucidum and related species by high performance liquid chromatography. J. Pharm. Biomed. 2006, 41:838-844.
    • (2006) J. Pharm. Biomed. , vol.41 , pp. 838-844
    • Wang, X.M.1    Yang, M.2    Guan, S.H.3    Liu, R.X.4    Xia, J.M.5    Bi, K.S.6    Guo, D.A.7
  • 16
    • 65249112247 scopus 로고    scopus 로고
    • Improved chromatographic fingerprints for facile differentiation of two Ganoderma spp.
    • Fu C.M., Lu G.H., Schmitz O.J., Li Z.W., Leung K.S.Y. Improved chromatographic fingerprints for facile differentiation of two Ganoderma spp. Biomed. Chromatogr. 2009, 23:280-288.
    • (2009) Biomed. Chromatogr. , vol.23 , pp. 280-288
    • Fu, C.M.1    Lu, G.H.2    Schmitz, O.J.3    Li, Z.W.4    Leung, K.S.Y.5
  • 17
    • 81255199673 scopus 로고    scopus 로고
    • Determination of ganoderic acids in rat plasma after oral administration of total triterpenoids from Ganoderma lucidum
    • Xue B.B., Guo X.Y., Che Q.M. Determination of ganoderic acids in rat plasma after oral administration of total triterpenoids from Ganoderma lucidum. J. Chin. Pharm. Sci. 2008, 17:236-240.
    • (2008) J. Chin. Pharm. Sci. , vol.17 , pp. 236-240
    • Xue, B.B.1    Guo, X.Y.2    Che, Q.M.3
  • 18
    • 34147137262 scopus 로고    scopus 로고
    • HPLC method for the determination and pharmacokinetic studies of four triterpenoids in rat plasma after oral administration of Ganoderma lucidum extract
    • Wang X.M., Liu R.X., Sun J.H., Guan S.H., Yang M., Bi K.S., Guo D.A. HPLC method for the determination and pharmacokinetic studies of four triterpenoids in rat plasma after oral administration of Ganoderma lucidum extract. Biomed. Chromatogr. 2007, 21:389-396.
    • (2007) Biomed. Chromatogr. , vol.21 , pp. 389-396
    • Wang, X.M.1    Liu, R.X.2    Sun, J.H.3    Guan, S.H.4    Yang, M.5    Bi, K.S.6    Guo, D.A.7
  • 19
    • 33846653132 scopus 로고    scopus 로고
    • HPLC determination of four triterpenoids in rat urine after oral administration of total triterpenoids from Ganoderma lucidum
    • Wang X.M., Guan S.H., Liu R.X., Sun J.H., Liang Y., Yang M., Wang W., Bi K.S., Guo D.A. HPLC determination of four triterpenoids in rat urine after oral administration of total triterpenoids from Ganoderma lucidum. J. Pharm. Biomed. 2007, 43:1185-1190.
    • (2007) J. Pharm. Biomed. , vol.43 , pp. 1185-1190
    • Wang, X.M.1    Guan, S.H.2    Liu, R.X.3    Sun, J.H.4    Liang, Y.5    Yang, M.6    Wang, W.7    Bi, K.S.8    Guo, D.A.9
  • 20
    • 28044455818 scopus 로고    scopus 로고
    • Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
    • Gao J.J., Min B.S., Akao T., Meselhy M.R., Nakamura N., Hattori M. Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum. J. Tradit. Med. 2001, 18:154-160.
    • (2001) J. Tradit. Med. , vol.18 , pp. 154-160
    • Gao, J.J.1    Min, B.S.2    Akao, T.3    Meselhy, M.R.4    Nakamura, N.5    Hattori, M.6
  • 21
    • 84858080074 scopus 로고    scopus 로고
    • Quantitative determination of ganoderic acid T in rat plasma by a sensitive RP-HPLC method and its application in pharmacokinetic studies
    • Chen X., Tao S.L., Gao F., Li Y.B., Zhong J.J. Quantitative determination of ganoderic acid T in rat plasma by a sensitive RP-HPLC method and its application in pharmacokinetic studies. J. Chin. Pharm. Sci. 2010, 19:209-213.
    • (2010) J. Chin. Pharm. Sci. , vol.19 , pp. 209-213
    • Chen, X.1    Tao, S.L.2    Gao, F.3    Li, Y.B.4    Zhong, J.J.5
  • 22
    • 67650732691 scopus 로고    scopus 로고
    • Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum
    • Zhang Q., Zuo F., Nakamura N., Ma C.M., Hattori M. Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum. J. Nat. Med. 2009, 63:304-310.
    • (2009) J. Nat. Med. , vol.63 , pp. 304-310
    • Zhang, Q.1    Zuo, F.2    Nakamura, N.3    Ma, C.M.4    Hattori, M.5
  • 23
    • 34247181278 scopus 로고    scopus 로고
    • Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry
    • Yang M., Wang X.M., Guan S.H., Xia J.M., Sun J.H., Guo H., Guo D.A. Analysis of triterpenoids in Ganoderma lucidum using liquid chromatography coupled with electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom. 2007, 18:927-939.
    • (2007) J. Am. Soc. Mass Spectrom. , vol.18 , pp. 927-939
    • Yang, M.1    Wang, X.M.2    Guan, S.H.3    Xia, J.M.4    Sun, J.H.5    Guo, H.6    Guo, D.A.7
  • 24
    • 79954445763 scopus 로고    scopus 로고
    • Fragmentation pathways of oxygenated tetracyclic triterpenoids and their application in the qualitative analysis of Ganoderma lucidum by multistage tandem mass spectrometry
    • Cheng C.R., Yang M., Wu Z.Y., Wang Y., Zeng F., Wu W.Y., Guan S.H., Guo D.A. Fragmentation pathways of oxygenated tetracyclic triterpenoids and their application in the qualitative analysis of Ganoderma lucidum by multistage tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25:1323-1335.
    • (2011) Rapid Commun. Mass Spectrom. , vol.25 , pp. 1323-1335
    • Cheng, C.R.1    Yang, M.2    Wu, Z.Y.3    Wang, Y.4    Zeng, F.5    Wu, W.Y.6    Guan, S.H.7    Guo, D.A.8
  • 25
    • 34547720171 scopus 로고    scopus 로고
    • Chemical constituents from fruiting bodies of Ganoderma lucidum
    • Zhang X.Q., Yin Z.Q., Ye W.C., Zhao S.X. Chemical constituents from fruiting bodies of Ganoderma lucidum. Chin. Tradit. Herb. Drugs 2005, 36:1601-1603.
    • (2005) Chin. Tradit. Herb. Drugs , vol.36 , pp. 1601-1603
    • Zhang, X.Q.1    Yin, Z.Q.2    Ye, W.C.3    Zhao, S.X.4
  • 26
    • 85008107815 scopus 로고
    • Constituents of the fungus Ganoderma lucidem (Fr.) Karst. II. Structures of ganoderic acids F, G, and H, lucidenic acids D2 and E2, and related compounds
    • Kikuchi T., Kanomi S., Murai Y., Kadota S., Tsubono K., Ogita Z.I. Constituents of the fungus Ganoderma lucidem (Fr.) Karst. II. Structures of ganoderic acids F, G, and H, lucidenic acids D2 and E2, and related compounds. Chem. Pharm. Bull. 1986, 34:4018-4029.
    • (1986) Chem. Pharm. Bull. , vol.34 , pp. 4018-4029
    • Kikuchi, T.1    Kanomi, S.2    Murai, Y.3    Kadota, S.4    Tsubono, K.5    Ogita, Z.I.6
  • 29
    • 0022966594 scopus 로고
    • Constituents of the fungus Ganoderma lucidem (Fr.) Karst. I. Structures of ganoderic acids C2, E, I, and K, lucidenic acids F and related compounds
    • Kikuchi T., Kanomi S., Kadota S., Murai Y., Tsubono K., Ogita Z.I. Constituents of the fungus Ganoderma lucidem (Fr.) Karst. I. Structures of ganoderic acids C2, E, I, and K, lucidenic acids F and related compounds. Chem. Pharm. Bull. 1986, 34:3695-3712.
    • (1986) Chem. Pharm. Bull. , vol.34 , pp. 3695-3712
    • Kikuchi, T.1    Kanomi, S.2    Kadota, S.3    Murai, Y.4    Tsubono, K.5    Ogita, Z.I.6
  • 30
    • 0343229481 scopus 로고
    • New terpenoids, ganolucidic acid D, ganoderic acid L, lucidone C and lucidenic acid G, from the fungus Ganoderma lucidum
    • Nishitoba T., Sato H., Sakamura S. New terpenoids, ganolucidic acid D, ganoderic acid L, lucidone C and lucidenic acid G, from the fungus Ganoderma lucidum. Agric. Biol. Chem. 1986, 50:809-811.
    • (1986) Agric. Biol. Chem. , vol.50 , pp. 809-811
    • Nishitoba, T.1    Sato, H.2    Sakamura, S.3
  • 31
    • 0008199699 scopus 로고
    • New terpenoids, ganoderic acid J and ganolucidic acid C, from the fungus Ganoderma lucidum
    • Nishitoba T., Sato H., Sakamura S. New terpenoids, ganoderic acid J and ganolucidic acid C, from the fungus Ganoderma lucidum. Agric. Biol. Chem. 1985, 49:3637-3638.
    • (1985) Agric. Biol. Chem. , vol.49 , pp. 3637-3638
    • Nishitoba, T.1    Sato, H.2    Sakamura, S.3
  • 32
    • 16544395588 scopus 로고    scopus 로고
    • Quantitative determination of bitter principles in specimens of Ganoderma lucidum using high-performance liquid chromatography and its application to the evaluation of ganoderma products
    • Gao J.J., Nakamura N., Min B.S., Hirakawa A., Zuo F., Hattori M. Quantitative determination of bitter principles in specimens of Ganoderma lucidum using high-performance liquid chromatography and its application to the evaluation of ganoderma products. Chem. Pharm. Bull. 2004, 52:688-695.
    • (2004) Chem. Pharm. Bull. , vol.52 , pp. 688-695
    • Gao, J.J.1    Nakamura, N.2    Min, B.S.3    Hirakawa, A.4    Zuo, F.5    Hattori, M.6
  • 34
    • 0001028999 scopus 로고
    • Triterpenoids from the fungus Ganoderma lucidum
    • Nishitoba T., Sato H., Sakamura S. Triterpenoids from the fungus Ganoderma lucidum. Phytochemistry 1987, 26:1777-1784.
    • (1987) Phytochemistry , vol.26 , pp. 1777-1784
    • Nishitoba, T.1    Sato, H.2    Sakamura, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.