Separation and identification of degradation products in eprinomectin formulation using LC, LTQ FT-MS, H/D exchange, and NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 63, Issue , 2012, Pages 62-73

  Awasthi, Atul ^a   Razzak, Majid ^b   Al Kassas, Raida ^a   Greenwood, David R ^c   Harvey, Joanne ^d   Garg, Sanjay ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Ancare Scientific Ltd Auckland   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

Eprinomectin degradation products; Geometric and structural isomers; H D exchange; High resolution FT MS and MSn; NMR

Indexed keywords

EPRINOMECTIN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLLISIONALLY ACTIVATED DISSOCIATION; DEUTERIUM HYDROGEN EXCHANGE; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG ISOLATION; DRUG PURIFICATION; FOURIER TRANSFORM MASS SPECTROMETRY; HEAT STRESS; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTHELMINTICS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DEUTERIUM EXCHANGE MEASUREMENT; DRUG CONTAMINATION; DRUG STABILITY; HOT TEMPERATURE; IVERMECTIN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84858080902     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.12.030     Document Type: Article

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