Exploiting the addition of trimethyl(trifluoromethyl)silane to functionalized N-benzylimines for the preparation of two novel x-trifluoromethyl x-amino acids

Synthesis

Volumn 44, Issue 6, 2012, Pages 903-908

  Tkachenko, Anton N ^a,b   Radchenko, Dmytro S ^a,b   Mykhailiuk, Pavel K ^a,b   Shishkin, Oleg V ^c,d   Tolmachev, Andrei A ^a,b   Komarov, Igor V ^a,b  

^a ENAMINE LTD   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^c INSTITUTE FOR SINGLE CRYSTALS   (Ukraine)

^d V N KARAZIN KHARKIV NATIONAL UNIVERSITY   (Ukraine)

Author keywords

alkylations; amino acids; fluorine; imines; peptidomimetics

Indexed keywords

ESTER GROUPS; FUNCTIONALIZED; GENERAL APPROACH; GRAM-SCALE SYNTHESIS; IMINES; NUCLEOPHILIC TRIFLUOROMETHYLATION; PEPTIDOMIMETICS; TRIFLUOROMETHYL; TRIMETHYL;

ALKYLATION; FLUORINE;

AMINO ACIDS;

3 AMINO 3 (TRIFLUOROMETHYL)CYCLOBUTANECARBOXYLIC ACID; 6 AMINO 6 (TRIFLUOROMETHYL)SPIRO[3.3]HEPTANE 2 CARBOXYLIC ACID; AMINO ACID DERIVATIVE; EPSILON TRIFLUOROMETHYL EPSILON AMINO ACID; ESTER DERIVATIVE; GAMMA TRIFLUOROMETHYL GAMMA AMINO ACID; IMINE; METHYL 3 (BENZYLIMINO) 3 (TRIFLUOROMETHYL)CYCLOBUTANECARBOXYLIC ACID; METHYL 3 (BENZYLIMINO)CYCLOBUTANECARBOXYLIC ACID; METHYL 6 (BENZYLIMINO) 6 (TRIFLUOROMETHYL)SPIRO[3.3]HEPTANE 2 CARBOXYLIC ACID; METHYL 6 (BENZYLIMINO)SPIRO[3.3]HEPTANE 2 CARBOXYLIC ACID; N BENZYLIMINE DERIVATIVE; REAGENT; TRIMETHYL(TRIFLUOROMETHYL)SILANE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 84858072117     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0031-1289702     Document Type: Article

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