Nucleophilic trifluoromethylation of imines under acidic conditions

European Journal of Organic Chemistry

Volumn , Issue 31, 2008, Pages 5226-5230

  Levin, Vitalij V ^a   Dilman, Alexander D ^a   Belyakov, Pavel A ^a   Struchkova, Marina I ^a   Tartakovsky, Vladimir A ^a  

^a N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Fluorine; Imines; Schiff bases; Silicon; Trifluoromethylation

Indexed keywords

EID: 55049117569     PISSN: 1434193X     EISSN: 10990690     Source Type: Journal    
DOI: 10.1002/ejoc.200800820     Document Type: Article

References (61)

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58. [13d]
59. The contribution of attack on the keto group did not exceed 1%, as judged by analysis of crude NMR spectra.
60. In fact, even benzaldehyde was found to be unreactive under the conditions of methods B and C. However, by using method A, trifluoromethylation occurred slowly with 20% conversion to the corresponding 2,2,2-trifluoro-1- phenylethanol.
61. [14b]