Substituted 3-(5-imidazo[2,1- b ]thiazolylmethylene)-2-indolinones and analogues: Synthesis, cytotoxic activity, and study of the mechanism of action(1)

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2078-2088

  Andreani, Aldo ^a   Granaiola, Massimiliano ^a   Locatelli, Alessandra ^a   Morigi, Rita ^a   Rambaldi, Mirella ^a   Varoli, Lucilla ^a   Calonghi, Natalia ^a   Cappadone, Concettina ^a   Farruggia, Giovanna ^a   Stefanelli, Claudio ^a   Masotti, Lanfranco ^a   Nguyen, Tam L ^b   Hamel, Ernest ^c   Shoemaker, Robert H ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [5 IMIDAZO(2,1 B)THIAZOLYLMETHYLENE] 2 INDOLINONE; ANTINEOPLASTIC AGENT; COMBRETASTATIN A4; NSC 742500; NSC 743420; NSC 744489; NSC 748113; NSC 748114; NSC 748115; NSC 748117; NSC 748118; NSC 748119; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; NATIONAL HEALTH ORGANIZATION; PROTEIN ASSEMBLY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; G2 PHASE; HUMANS; IMIDAZOLES; INDOLES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUBULIN; TUBULIN MODULATORS;

EID: 84858061441     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2012694     Document Type: Article

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