Synthesis and antitumor activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones

Anti-Cancer Drug Design

Volumn 16, Issue 2-3, 2001, Pages 167-174

  Andreani, Aldo ^a   Granaiola, Massimiliano ^a   Leoni, Alberto ^a   Locatelli, Alessandra ^a   Morigi, Rita ^a   Rambaldi, Mirella ^a   Giorgi, Gianluca ^a   Salvini, Laura ^a   Garaliene, Vida ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antitumor activity; Cardiotonic activity; Cytotoxicity; Imidazothiazole; Indole

Indexed keywords

3 (5 IMIDAZO[2,1 B]THIAZOLYLMETHYLENE) 2 INDOLINONE DERIVATIVE; 3 [(2,6 DIMETHYLIMIDAZO[2,1 B]THIAZOL 5 YL)METHYLENE] 5 METHOXY 2 INDOLINONE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ISOMERISM; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CDC2 PROTEIN KINASE; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0035728164     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Synthesis and potential coanthracyclinic activity of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
2. Potential antitumor agents. 29. Synthesis and potential coanthracyclinic activity of imidazo[2,1-b]thiazole guanylhydrazones
3. Imidazo[2,1-b]thiazolylmethylene- and indolylmethylene-2-indolinones: A new class of cyclin-dependent kinase inhibitors. Design, synthesis, and cdk1/ cyclin b inhibition
4. The structure of yellow pigments from the rhizomes of Cimicifuga dahurica Maxim
5. Molecular structure, characterization and stereo-chemical properties of new biologically interesting 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones
6. Substituted indolinones as kinase inhibitors
7. In vivo cultivation of tumor cells in hollow fibers
8. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
9. Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
10. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
11. Heterodiene syntheses. Part 21. 1-Acetyl-2-oxoindolin-3-ylideneacetophenones and ethoxyethyne: Spirobicyclic intermediates in competition with [2 + 2]- and [4 + 2]-cycloadditions
12. Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation
13. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
14. Identification of substituted 3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (F1k-1/KDR), FGF-R1, and PDGF-Rβ tyrosine kinases
15. Inhibition of tumor growth, angiogenesis, and microcirculation by the novel F1k-1 inhibitor SU5416 as assessed by intravital multifluorescence videomicroscopy