Antitumor activity of new substituted 3-(5-imidazo[2,1-b] thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)- 2-indolinones: Selectivity against colon tumor cells and effect on cell cycle-related events

Journal of Medicinal Chemistry

Volumn 51, Issue 23, 2008, Pages 7508-7513

  Andreani, Aldo ^a   Burnelli, Silvia ^a   Granaiola, Massimiliano ^a   Leoni, Alberto ^a   Locatelli, Alessandra ^a   Morigi, Rita ^a   Rambaldi, Mirella ^a   Varoli, Lucilla ^a   Calonghi, Natalia ^a   Cappadone, Concettina ^a   Voltattorni, Manuela ^a   Zini, Maddalena ^a   Stefanelli, Claudio ^a   Masotti, Lanfranco ^a   Shoemaker, Robert H ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 IMIDAZO[2,1 B]THIADIAZOLYLMETHYLENE) 2 INDOLINONE DERIVATIVE; 3 (5 IMIDAZO[2,1 B]THIAZOLYLMETHYLENE) 2 INDOLINONE DERIVATIVE; ANTINEOPLASTIC AGENT; ORNITHINE DECARBOXYLASE; UNCLASSIFIED DRUG; VINCRISTINE SULFATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN HT29; COLON TUMOR; CYTOSTASIS; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; POLYAMINE SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HT29 CELLS; HUMANS; INDOLES; MOLECULAR STRUCTURE; ORNITHINE DECARBOXYLASE; POLYAMINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 57349088707     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800827q     Document Type: Article

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