Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Payer, D E ^a   Nurmi, E L ^a   Wilson, S A ^a   McCracken, J T ^a   London, E D ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aggression; Amygdala; Methamphetamine; Prefrontal cortex; SERT LPR; STin2 VNTR

Indexed keywords

METHAMPHETAMINE; SEROTONIN TRANSPORTER; CENTRAL STIMULANT AGENT; SLC6A4 PROTEIN, HUMAN;

ADULT; AGGRESSION; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG ABUSE; EMOTION; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE CELL NETWORK; VARIABLE NUMBER TANDEM REPEAT POLYMORPHISM; AMYGDALOID NUCLEUS; BRAIN; BRAIN MAPPING; FACIAL EXPRESSION; FRONTAL LOBE; GENETIC PREDISPOSITION; GENETICS; INTRON; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGICAL ASPECT; QUESTIONNAIRE; VARIABLE NUMBER OF TANDEM REPEAT; WITHDRAWAL SYNDROME;

ADULT; AGGRESSION; ALLELES; AMPHETAMINE-RELATED DISORDERS; AMYGDALA; BRAIN; BRAIN MAPPING; CENTRAL NERVOUS SYSTEM STIMULANTS; EMOTIONS; FACIAL EXPRESSION; FEMALE; FRONTAL LOBE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; INTRONS; MAGNETIC RESONANCE IMAGING; MALE; METHAMPHETAMINE; MIDDLE AGED; MINISATELLITE REPEATS; NERVE NET; OCCIPITAL LOBE; PATTERN RECOGNITION, VISUAL; PREFRONTAL CORTEX; QUESTIONNAIRES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84858017052     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.73     Document Type: Article

References (75)

1. Boles SM, Miotto K. Substance abuse and violence: a review of the literature. Aggress Violent Behav 2003; 8: 155-174. (Pubitemid 36149755)
2. Cohen JB, Dickow A, Horner K, Zweben JE, Balabis J, Vandersloot D et al. Abuse and violence history of men and women in treatment for methamphetamine dependence. Am J Addict 2003; 12: 377-385. (Pubitemid 37449024)
3. Baskin-Sommers A, Sommers I. Methamphetamine use and violence among young adults. J Crim Just 2006; 34: 661-674. (Pubitemid 44767255)
4. Cartier J, Farabee D, Prendergast ML. Methamphetamine use, self-reported violent crime, and recidivism among offenders in California who abuse substances. J Interpers Violence 2006; 21: 435-445. (Pubitemid 43319896)
5. Sekine Y, Ouchi Y, Takei N, Yoshikawa E, Nakamura K, Futatsubashi M et al. Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Arch Gen Psychiatry 2006; 63: 90-100. (Pubitemid 43037473)
6. Payer DE, Lieberman MD, Monterosso JR, Xu J, Fong TW, London ED. Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task. Drug Alcohol Depend 2008; 93: 93-102. (Pubitemid 350236596)
7. Hamilton A, Goeders N. Violence perpetrated by women who use methamphetamine. J Substance Use 2010; 15: 313-329.
8. Payer DE, Lieberman MD, London ED. Neural correlates of affect processing and aggression in methamphetamine dependence. Arch Gen Psychiatry 2011; 68: 271-282.
9. Coccaro EF. Neurotransmitter correlates of impulsive aggression in humans. Ann N Y Acad Sci 1996; 794: 82-89. (Pubitemid 26361548)
10. Nelson RJ, Trainor BC. Neural mechanisms of aggression. Nat Rev Neurosci 2007; 8: 536-546. (Pubitemid 46985366)
11. Davidson RJ, Putnam KM, Larson CL. Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence. Science 2000; 289: 591-594. (Pubitemid 30622056)
12. Siever LJ. Neurobiology of aggression and violence. Am J Psychiatry 2008; 165: 429-442. (Pubitemid 351694285)
13. Baicy K, London ED. Corticolimbic dysregulation and chronic methamphetamine abuse. Addiction 2007; 102(Suppl 1): 5-15. (Pubitemid 46328215)
14. Payer D, London ED. Methamphetamine and the brain: findings from brain imaging studies. In: Roll JM, Rawson R, Ling W, Shoptaw S (eds). Methamphetamine Addiction: From Basic Science to Treatment. Guildford Press: New York, 2009, pp 61-91.
15. Kish SJ, Fitzmaurice PS, Boileau I, Schmunk GA, Ang LC, Furukawa Y et al. Brain serotonin transporter in human methamphetamine users. Psychopharmacology (Berl) 2009; 202: 649-661.
16. Homer BD, Solomon TM, Moeller RW, Mascia A, DeRaleau L, Halkitis PN. Methamphetamine abuse and impairment of social functioning: a review of the underlying neurophysiological causes and behavioral implications. Psychol Bull 2008; 134: 301-310.
17. Henry JD, Mazur M, Rendell PG. Social-cognitive difficulties in former users of methamphetamine. Br J Clin Psychol 2009; 48: 323-327.
18. Kim YT, Kwon DH, Chang Y. Impairments of facial emotion recognition and theory of mind in methamphetamine abusers. Psychiatry Res 2010; Jul: 17.
19. Goldstein RZ, Craig AD, Bechara A, Garavan H, Childress AR, Paulus MP et al. The neurocircuitry of impaired insight in drug addiction. Trends Cogn Sci 2009; 13: 372-380.
20. Goldstein RZ, Volkow ND, Chang L, Wang GJ, Fowler JS, Depue RA et al. The orbitofrontal cortex in methamphetamine addiction: involvement in fear. NeuroReport 2002; 13: 2253-2257. (Pubitemid 36044438)
21. London ED, Simon SL, Berman SM, Mandelkern MA, Lichtman AM, Bramen J et al. Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch Gen Psychiatry 2004; 61: 73-84. (Pubitemid 38044643)
22. Gonzales R, Mooney L, Rawson RA. The methamphetamine problem in the United States. Annu Rev Public Health 2010; 31: 385-398.
23. Li CS, Sinha R. Inhibitory control and emotional stress regulation: neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction. Neurosci Biobehav Rev (Research Support, NIH, Extramural Research Support, Non-US Gov't Review) 2008; 32: 581-597.
24. Yamamoto BK, Moszczynska A, Gudelsky GA. Amphetamine toxicities: classical and emerging mechanisms. Ann N Y Acad Sci 2010; 1187: 101-121.
25. Krasnova IN, Cadet JL. Methamphetamine toxicity and messengers of death. Brain Res Rev 2009; 60: 379-407.
26. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 2003; 8: 574-591. (Pubitemid 36898017)
27. Serretti A, Calati R, Mandelli L, De Ronchi D. Serotonin transporter gene variants and behavior: a comprehensive review. Curr Drug Targets 2006; 7: 1659-1669. (Pubitemid 44873728)
28. Wrase J, Reimold M, Puls I, Kienast T, Heinz A. Serotonergic dysfunction: brain imaging and behavioral correlates. Cogn Affect Behav Neurosci 2006; 6: 53-61.
29. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006; 11: 224-226.
30. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624. (Pubitemid 26159101)
31. Haberstick BC, Smolen A, Hewitt JK. Family-based association test of the 5HTTLPR and aggressive behavior in a general population sample of children. Biol Psychiatry 2006; 59: 836-843.
32. Gerra G, Garofano L, Castaldini L, Rovetto F, Zaimovic A, Moi G et al. Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. J Neural Transm 2005; 112: 1397-1410. (Pubitemid 41355968)
33. Lesch KP, Merschdorf U. Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 2000; 18: 581-604. (Pubitemid 32006046)
34. Beitchman JH, Baldassarra L, Mik H, De Luca V, King N, Bender D et al. Serotonin transporter polymorphisms and persistent, pervasive childhood aggression. Am J Psychiatry 2006; 163: 1103-1105. (Pubitemid 44464500)
35. Sakai JT, Young SE, Stallings MC, Timberlake D, Smolen A, Stetler GL et al. Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. Am J Med Genet (Neuropsychiatr Genet) 2006; 141B: 825-832. (Pubitemid 44905435)
36. Lotrich FE, Pollock BG. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 2004; 14: 121-129. (Pubitemid 39281818)
37. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B 2004; 127B: 85-89. (Pubitemid 38542320)
38. Schinka JA, Busch RM, Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 2004; 9: 197-202. (Pubitemid 38299534)
39. Way BM, Lieberman MD. Is there a genetic contribution to cultural differences? Collectivism, individualism and genetic markers of social sensitivity. Soc Cogn Affect Neurosci 2010; 5: 203-211.
40. Izquierdo A, Newman TK, Higley JD, Murray EA. Genetic modulation of cognitive flexibility and socioemotional behavior in rhesus monkeys. Proc Natl Acad Sci USA 2007; 104: 14128-14133. (Pubitemid 350003346)
41. Chiao JY, Blizinsky KD. Culture-gene coevolution of individualism- collectivism and the serotonin transporter gene. Proc Biol Sci 2010; 277: 529-537.
42. Pacheco J, Beevers CG, Benavides C, McGeary J, Stice E, Schnyer DM. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci 2009; 29: 6229-6233.
43. Brown SM, Hariri AR. Neuroimaging studies of serotonin gene polymorphisms: exploring the interplay of genes, brain, and behavior. Cogn Affect Behav Neurosci 2006; 6: 44-52.
44. Frodl T, Koutsouleris N, Bottlender R, Born C, Jager M, Morgenthaler M et al. Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression. Mol Psychiatry 2008; 13: 1093-1101.
45. Beitchman JH, Davidge KM, Kennedy JL, Atkinson L, Lee V, Shapiro S et al. The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls. Ann N Y Acad Sci 2003; 1008: 248-251. (Pubitemid 38265167)
46. Davidge KM, Atkinson L, Douglas L, Lee V, Shapiro S, Kennedy JL et al. Association of the serotonin transporter and 5HT1Dbeta receptor genes with extreme, persistent and pervasive aggressive behaviour in children. Psychiatr Genet 2004; 14: 143-146. (Pubitemid 39281821)
47. Collier DA, Arranz MJ, Sham P, Battersby S, Vallada H, Gill P et al. The serotonin transporter is a potential susceptibility factor for bipolar affective disorder. NeuroReport 1996; 7: 1675-1679. (Pubitemid 26332347)
48. Ohara K, Suzuki Y, Ochiai M, Tsukamoto T, Tani K. A variable-number- tandem-repeat of the serotonin transporter gene and anxiety disorders. Prog Neuropsychopharmacol Biol Psychiatry 1999; 23: 55-65. (Pubitemid 29098902)
49. Baca-Garcia E, Vaquero-Lorenzo C, Diaz-Hernandez M, Rodriguez-Salgado B, Dolengevich-Segal H, Arrojo-Romero M et al. Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene. Prog Neuro-Psychopharmacol Biol Psychiatry 2007; 31: 416-420. (Pubitemid 46210229)
50. Oades RD, Lasky-Su J, Christiansen H, Faraone SV, Sonuga-Barke EJ, Banaschewski T et al. The influence of serotonin-and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct 2008; 4: 48.
51. Aluja A, Garcia LF, Blanch A, De Lorenzo D, Fibla J. Impulsive- disinhibited personality and serotonin transporter gene polymorphisms: association study in an inmate's sample. J Psychiatr Res 2009; 43: 906-914.
52. Ali FR, Vasiliou SA, Haddley K, Paredes UM, Roberts JC, Miyajima F et al. Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by CTCF. J Neurochem 2010; 112: 296-306.
53. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 2004; 55: 1090-1094. (Pubitemid 38680561)
54. Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y et al. Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. Ann N Y Acad Sci 2008; 1139: 49-56.
55. Hong CJ, Cheng CY, Shu LR, Yang CY, Tsai SJ. Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males. J Neural Transm 2003; 110: 345-351.
56. First MB, Spitzer RL, Gibbon M, Williams JBW. The Structured Clinical Interview for DSMIV Axis I Disorders (SCID-IP). American Psychiatric Press: Washington, DC, 1995.
57. Buss AH, Perry M. The aggression questionnaire. J Pers Soc Psychol 1992; 63: 452-459.
58. Sergerie K, Chochol C, Armony JL. The role of the amygdala in emotional processing: a quantitative meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 2008; 32: 811-830.
59. Tottenham N, Tanaka J, Leon AC, McCarry T, Nurse M, Hare TA et al. The NimStim set of facial expressions: Judgments from untrained research participants. Psychiatry Res 2009; 168: 242-249.
60. Zorick T, Nestor L, Miotto K, Sugar C, Hellemann G, Scanlon G et al. Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction 2010; 105: 1809-1818.
61. Lovejoy EA, Scott AC, Fiskerstrand CE, Bubb VJ, Quinn JP. The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit. Eur J Neurosci (Research Support, Non-US Gov't) 2003; 17: 417-420. (Pubitemid 36459521)
62. Patenaude B, Smith S, Kennedy D, Jenkinson M. FIRST-FMRIB's Integrated Registration and Segmentation Tool. Annual Meeting of the Organization for Human Brain Mapping 2007; Chicago, IL.
63. Brett M, Anton JL, Valabregue R, Poline JB. Region of interest analysis using an SPM toolbox. NeuroImage 2002; 16: 1140-1141.
64. Lieberman MD, Cunningham WA. Type I and Type II error concerns in fMRI research: rebalancing the scale. Soc Cogn Affect Neurosci 2009; 4: 423-428.
65. Craig IW, Halton KE. Genetics of human aggressive behaviour. Hum Genet 2009; 126: 101-113.
66. Schafer I, Langeland W, Hissbach J, Luedecke C, Ohlmeier MD, Chodzinski C; et al. Childhood trauma and dissociation in patients with alcohol dependence, drug dependence, or both-a multi-center study. Drug Alcohol Depend 2010; 109: 84-89.
67. Canli T, Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 2007; 10: 1103-1109. (Pubitemid 47339957)
68. Canli T, Qiu M, Omura K, Congdon E, Haas BW, Amin Z et al. Neural correlates of epigenesis. Proc Natl Acad Sci USA 2006; 103: 16033-16038. (Pubitemid 44657587)
69. Rao H, Gillihan SJ, Wang J, Korczykowski M, Sankoorikal GM, Kaercher KA et al. Genetic variation in serotonin transporter alters resting brain function in healthy individuals. Biol Psychiatry 2007; 62: 600-606. (Pubitemid 47314381)
70. Heinz A, Smolka MN, Braus DF, Wrase J, Beck A, Flor H et al. Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation. Biol Psychiatry 2007; 61: 1011-1014. (Pubitemid 46482463)
71. Haxby JV, Hoffman EA, Gobbini MI. The distributed human neural system for face perception. Trends Cogn Sci 2000; 4: 223-233. (Pubitemid 30332148)
72. Adolphs R. Recognizing emotion from facial expressions: psychological and neurological mechanisms. Behav Cogn Neurosci Rev 2002; 1: 21-62.
73. Lee E, Kang JI, Park IH, Kim JJ, An SK. Is a neutral face really evaluated as being emotionally neutral? Psychiatry Res (Research Support, Non-US Gov't Validation Studies) 2008; 157: 77-85. (Pubitemid 350166543)
74. Pinkham AE, Brensinger C, Kohler C, Gur RE, Gur RC. Actively paranoid patients with schizophrenia over attribute anger to neutral faces. Schizophr Res (Research Support, NIH, Extramural) 2011; 125: 174-178.
75. Kleinhans NM, Johnson LC, Mahurin R, Richards T, Stegbauer KC, Greenson J et al. Increased amygdala activation to neutral faces is associated with better face memory performance. NeuroReport (Research Support, NIH, Extramural) 2007; 18: 987-991. (Pubitemid 46905170)