Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane

Gene Therapy

Volumn 19, Issue 3, 2012, Pages 255-263

  Wang, H ^a   Murphy, R ^b   Taaffe, D ^b   Yin, S ^a   Xia, L ^a   Hauswirth, W W ^c   Bance, M ^b   Robertson, G S ^d   Wang, J ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b DALHOUSIE UNIVERSITY   (Canada)

^c UNIVERSITY OF FLORIDA   (United States)

^d DALHOUSIE UNIVERSITY   (Canada)

Author keywords

adeno associated viral vector; cochlear gene transfection; collagenase; hair cell; round window membrane; spiral ganglion neuron

Indexed keywords

COLLAGENASE; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; COCHLEA; CONTROLLED STUDY; ENZYME ACTIVITY; EVOKED BRAIN STEM AUDITORY RESPONSE; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; HEARING LOSS; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; ROUND WINDOW MEMBRANE;

ANIMALS; COCHLEA; DEPENDOVIRUS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GUINEA PIGS; HAIR CELLS, AUDITORY; HUMANS; MALE; ROUND WINDOW, EAR; TRANSFECTION;

ADENO-ASSOCIATED VIRUS; CAVIA;

EID: 84858005451     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.91     Document Type: Article

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