Proliferation centers in chronic lymphocytic leukemia: Correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays

Leukemia

Volumn 26, Issue 3, 2012, Pages 499-508

  Ciccone, M ^a   Agostinelli, C ^b   Rigolin, G M ^a   Piccaluga, P P ^b   Cavazzini, F ^a   Righi, S ^b   Sista, M T ^b   Sofritti, O ^a   Rizzotto, L ^a   Sabattini, E ^b   Fioritoni, G ^c   Falorio, S ^c   Stelitano, C ^d   Olivieri, A ^e   Attolico, I ^e   Brugiatelli, M ^f   Zinzani, P L ^g   Saccenti, E ^a   Capello, D ^h   Negrini, M ^a   Cuneo, A ^a   Pileri, S ^b   more..

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c Ospedale Civile di Pescara   (Italy)

^d Hematology Unit   (Italy)

^e SAN CARLO HOSPITAL   (Italy)

^f Ospedale Papardo   (Italy)

^g UNIVERSITY OF BOLOGNA   (Italy)

^h UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

14q32 translocation; chronic lymphocytic leukemia; FISH; proliferation centers; small lymphocytic lymphoma

Indexed keywords

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; CORRELATION ANALYSIS; CYTOGENETICS; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; PRIORITY JOURNAL; TISSUE MICROARRAY;

CHROMOSOME ABERRATIONS; FEMALE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MUTATION; PROGNOSIS; RISK FACTORS; TISSUE ARRAY ANALYSIS;

EID: 84858001439     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.247     Document Type: Article

References (48)

1. Juliusson G, Oscier DG, Fitchett M, Ross FM, Stockdill G, Mackie MJ et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities. N Engl J Med 1990; 323: 720-724. (Pubitemid 20288941)
2. Stilgenbauer S, Bullinger L, Lichter P, Döhner H. Chronic lymphocytic leukemia. Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course. Leukemia 2002; 16: 993-1007. (Pubitemid 34618838)
3. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916. (Pubitemid 32064784)
4. Döhner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995; 85: 1580-1589.
5. Döhner H, Stilgenbauer S, James MR, Benner A, Weilguni T, Bentz M et al. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 1997; 89: 2516-2522. (Pubitemid 27143300)
6. Offit K, Louie DC, Parsa NZ, Filippa D, Gangi M, Siebert R et al. Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23). Blood 1994; 83: 2611-2618. (Pubitemid 24135854)
7. Stilgenbauer S, Bullinger L, Benner A, Wildenberger K, Bentz M, Döhner K et al. Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia. Leukemia 1999; 13: 1331-1334. (Pubitemid 29429758)
8. Cuneo A, Rigolin GM, Bigoni R, De Angeli C, Veronese A, Cavazzini F et al. Chronic lymphocytic leukemia with 6q- shows distinct hematological features and intermediate prognosis. Leukemia 2004; 18: 476-483. (Pubitemid 38425861)
9. Cavazzini F, Hernandez JA, Gozzetti A, Russo Rossi A, De Angeli C, Tiseo R et al. Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis. Br J Haematol 2008; 142: 529-537. (Pubitemid 352020210)
10. Haferlach C, Dicker F, Weiss T, Schnittger S, Beck C, Grote-Metke A et al. Toward a comprehensive prognostic scoring system in chronic lymphocytic leukemia based on a combination of genetic parameters. Genes Chromosomes Cancer 2010; 49: 851-859.
11. Müller-Hermelink HK, Montserrat E, Catovsky D, Campo E, Harris NL, Stein H. Chronic lymphocytic leukaemia/small lymphocytic lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe E, Pileri SA, Stein H, Thiele J, Vardimin JW (eds). WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues, 4th edn IARC (International Agency for Research on Cancer): Lyon, 2008, pp 180-184.
12. Schmid C, Isaacson PG. Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study. Histopathology 1994; 24: 445-451. (Pubitemid 24192314)
13. Caligaris-Cappio F. Role of the microenviroment in chronic lymphocitic leukemia. Br J Haematol 2003; 123: 380-388. (Pubitemid 37363477)
14. Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 2008; 26: 4497-4503.
15. Ben-Ezra J, Burke JS, Swartz WG, Brownell MD, Brynes RK, Hill LR et al. Small lymphocytic lymphoma: a clinicopathological analysis of 268 cases. Blood 1989; 73: 579-587. (Pubitemid 19060546)
16. Asplund SL, McKenna RW, Howard MS, Kroft SH. Immunophenotype does not correlate with lymph node histology in chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Surg Pathol 2002; 26: 624-629. (Pubitemid 34438722)
17. Swerdlow SH, Murray LJ, Habeshaw JA, Stansfeld AG. Lymphocytic lymphoma/B-chronic lymphocytic leukaemia: an immunohistopathological study of peripheral B lymphocyte neoplasia. Br J Cancer 1984; 50: 587-599. (Pubitemid 15211628)
18. Gin E, Martinez A, Villamor N, López-Guillermo A, Camos M, Martinez D et al. Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ('accelerated' chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica 2010; 95: 1526-1533.
19. Ventura RA, Martin-Subero JI, Jones M, McParland J, Gesk S, Mason DY et al. FISH analysis for the detection of lymphomaassociated chromosomal abnormalities in routine paraffinembedded tissue. J Mol Diagn 2006; 8: 141-151. (Pubitemid 43811236)
20. Matsumoto Y, Nomura K, Matsumoto S, Ueda K, Nakao M, Nishida K et al. Detection of t(14;18) in follicular lymphoma by dual-color fluorescence in situ hybridization on paraffin-embedded tissue sections. Cancer Genet Cytogenet 2004; 150: 22-26. (Pubitemid 38372197)
21. Voduc D, Kenney C, Nielsen TO. Tissue microarrays in clinical oncology. Semin Radiat Oncol 2008; 18: 89-97. (Pubitemid 351296453)
22. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O0Brien S et al. National Cancer Institute-Sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990-4997. (Pubitemid 26189840)
23. Rossi D, Cerri M, Capello D, Deambrogi C, Rossi FM, Zucchetto A et al. Biological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol 2008; 142: 202-215. (Pubitemid 351987315)
24. Bubendorf L, Nocito A, Moch H, Sauter G. Tissue microarray (TMA) technology: miniaturized pathology archives for highthroughput in situ studies. J Pathol 2001; 195: 72-79.
25. Brown LA, Huntsman D. Fluorescent in situ hybridization on tissue microarrays: challenges and solutions. J MolHistol 2007; 38: 151-157. (Pubitemid 46659334)
26. Wlodarska I, Matthews C, Veyt E, Pospisilova H, Catherwood MA, Poulsen TS et al. Telomeric IGH losses detectable by fluorescence in situ hybridization in chronic lymphocitic leukemia reflect somatic VH recombination events. J Mol Diagn 2007; 9: 47-54. (Pubitemid 47322013)
27. Meier C, Hoeller S, Bourgau C, Hirschmann P, Schwaller J, Went P et al. Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas. Mod Pathol 2009; 22: 476-487.
28. Rossi D, Berra E, Cerri M, Deambrogi C, Barbieri C, Franceschetti S et al. Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma. Haematologica 2006; 91: 1405-1409. (Pubitemid 44569818)
29. Flanagan MB, Sathanoori M, Surti U, Soma L, Swerdlow SH. Cytogenetic abnormalities detected by fluorescence in situ hybridization on paraffin-embedded chronic lymphocytic leukaemia/ small lymphocytic lymphoma lymphoid tissue biopsy specimens. Am J Clin Pathol 2008; 130: 620-627.
30. Caraway NP, Thomas E, Khanna A, Payne L, Zhang HZ, Lin E et al. Chromosomal abnormalities detected by multicolr fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival. Cancer 2008; 114: 315-322.
31. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, Massacane R et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood 2009; 114: 26-32.
32. Del Giudice I, Chiaretti S, Tavolaro S, De Propris MS, Maggio R, Mancini F et al. Spontaneous regression of chronic lymphocytic leukemia: clinical e biological features of 9 cases. Blood 2009; 114: 638-646.
33. Dal-Bo M, Del Giudice I, Bomben R, Capello D, Bertoni F, Forconi F et al. B- cell receptor, clinical course and prognosis in chronic lymphocytic leukemia: the growing saga of IGHV3 subgroup gene usage. Br J Haematol 2011; 153: 3-14.
34. Zenz T, Döhner H, Stilgenbauer S. Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia. Best Pract Res Clin Haematol 2007; 20: 439-453. (Pubitemid 47250492)
35. Byrd JC, Stilgenbauer S, Flinn IW. Chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Program 2004, 163-183.
36. Liso V, Capalbo S, Lapietra A, Pavone V, Guarini A, Specchia G. Evaluation of trisomy 12 by fluorescence in situ hybridization in peripheral blood, bone marrow and lymph nodes of patients with B-cell chronic lymphocytic leukemia. Haematologica 1999; 84: 212-217. (Pubitemid 29476923)
37. Juliusson G, Friberg K, Gahrton G. Consistency of chromosomal aberrations in chronic B-lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients. Cancer 1988; 62: 500-506.
38. Cuneo A, Bigoni R, Rigolin GM, Roberti MG, Bardi A, Cavazzini F et al. Late appearance of the 11q22.3-23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significance. Haematologica 2002; 87: 44-51. (Pubitemid 34101112)
39. Stilgenbauer S, Sander S, Bullinger L, Benner A, Leupolt E, Winkler D et al. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival. Haematologica 2007; 92: 1242-1245. (Pubitemid 350144184)
40. Cuneo A, Bardi A, Wlodarska I, Selleslag D, Roberti MG, Bigoni R et al. A novel recurrent translocation t(11;14)(p11;q32) in splenic marginal zone B cell lymphoma. Leukemia 2001; 15: 1262-1267. (Pubitemid 32776451)
41. Aoun P, Blair HE, Smith LM, Dave BJ, Lynch J, Weisenburger DD et al. Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. Leuk Lymphoma 2004; 45: 1595-1603. (Pubitemid 38886002)
42. Dierlamm J, Rosenberg C, Stul M, Pittaluga S, Wlodarska I, Michaux L et al. Characteristic pattern of chromosomal gains and losses in marginal zone B cell lymphoma detected by comparative genomic hybridization. Leukemia 1997; 11: 747-758. (Pubitemid 27241257)
43. Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039-1044. (Pubitemid 38160580)
44. Wright SM, Woo YH, Alley TL, Shirley BJ, Akeson EC, Snow KJ et al. Complex oncogenic translocations with gene amplificationare initiated by specific DNA breaks in lymphocytes. Cancer Res 2009; 69: 4454-4460.
45. Rossi D, Spina V, Deambrogi C, Rasi S, Laurenti L, Stamatopoulos K et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011; 117: 3391-3401.
46. Badoux XC, Keating MJ, Wang X, O0Brien SM, Ferrajoli A, Faderl S et al. Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. Blood 2011; 117: 3016-3024.
47. Dreger P, Döhner H, Ritgen M, Böttcher S, Busch R, Dietrich S et al. Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial. Blood 2010; 116: 2438-2447.
48. Michallet M, Sobh M, Milligan D, Morisset S, Niederwieser D, Koza V et al. The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL: a retrospective study from the EBMT registry. Leukemia 2010; 24: 1725-1731.