Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors

Biochemical and Biophysical Research Communications

Volumn 419, Issue 2, 2012, Pages 321-325

  Singh, Pushpendra ^a   Chattopadhyay, Amitabha ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Fluorescence anisotropy; Ligand binding; Serotonin1A receptor; Sphingolipid; Sphingomyelinase

Indexed keywords

LIGAND; SEROTONIN 1A RECEPTOR; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CELL MEMBRANE; COGNITION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GROWTH INHIBITION; HIPPOCAMPUS; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS;

ANIMALS; CATALYSIS; CELL MEMBRANE; HIPPOCAMPUS; LIGANDS; RECEPTOR, SEROTONIN, 5-HT1A; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINS;

EUKARYOTA;

EID: 84857999176     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.02.019     Document Type: Article

References (40)

1. Holthuis J.C., Pomorski T., Raggers R.J., Sprong H., van Meer G. The organizing potential of sphingolipids in intracellular membrane transport. Physiol. Rev. 2001, 81:1689-1723.
2. 1. Prog. Lipid Res. 2005, 44:345-356.
3. Bartke N., Hannun Y.A. Bioactive sphingolipids: metabolism and function. J. Lipid Res. 2009, 50:S91-S96.
4. Posse de Chaves E.I. Sphingolipids in apoptosis, survival and regeneration in the nervous system. Biochim. Biophys. Acta 2006, 1758:1995-2015.
5. Ramstedt B., Slotte J.P. Sphingolipids and the formation of sterol-enriched ordered membrane domains. Biochim. Biophys. Acta 2006, 1758:1945-1956.
6. Posse de Chaves E., Sipione S. Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction. FEBS Lett. 2010, 584:1748-1759.
7. Pierce K.L., Premont R.T., Lefkowitz R.J. Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 2002, 3:639-650.
8. Rosenbaum D.M., Rasmussen S.G.F., Kobilka B.K. The structure and function of G protein-coupled receptors. Nature 2009, 459:356-363.
9. Heilker R., Wolff M., Tautermann C.S., Bieler M. G-protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov. Today 2009, 14:231-240.
10. Schlyer S., Horuk R. I want a new drug: G-protein-coupled receptors in drug development. Drug Discov. Today 2006, 11:481-493.
11. 1A receptor: a representative member of the serotonin receptor family. Cell. Mol. Neurobiol. 2005, 25:553-580.
12. 1A-receptors. Prog. Neurobiol. 2007, 81:133-178.
13. 1A receptor in relation to human cognition. Behav. Brain Res. 2008, 195:103-111.
14. 1A receptor, an old target for new therapeutic agents. Curr. Top. Med. Chem. 2008, 8:1024-1034.
15. Gogos A., Bogeski M., van den Buuse M. Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology. Behav. Pharmacol. 2008, 19:548-561.
16. 1A receptors from bovine hippocampus. Cell. Mol. Neurobiol. 1998, 18:535-553.
17. 1A receptors: Implications in SLOS. Biochem. Biophys. Res. Commun. 2007, 363:800-805.
18. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., Klenk D.C. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985, 150:76-85.
19. Bruns R.F., Lawson-Wendling K., Pugsley T.A. A rapid filtration assay for soluble receptors using polyethylenimine-treated filters. Anal. Biochem. 1983, 132:74-81.
20. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
21. 1A receptors. Biochim. Biophys. Acta 2008, 1778:2022-2025.
22. van Echten-Deckert G. Sphingolipid extraction and analysis by thin-layer chromatography. Methods Enzymol. 2000, 312:64-79.
23. Amundson D.M., Zhou M. Fluorometric method for the enzymatic determination of cholesterol. J. Biochem. Biophys. Methods 1999, 38:43-52.
24. McClare C.W.F. An accurate and convenient organic phosphorus assay. Anal. Biochem. 1971, 39:527-530.
25. 1A receptor: implications in SLOS. Biochem. Biophys. Res. Commun. 2007, 358:495-499.
26. Lentz B.R., Moore B.M., Barrow D.A. Light-scattering effects in the measurement of membrane microviscosity with diphenylhexatriene. Biophys. J. 1979, 25:489-494.
27. Lakowicz J.R. Principles of Fluorescence Spectroscopy 2006, Springer, New York. third ed.
28. Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem. Phys. Lipids 1999, 102:79-96.
29. Goñi F.M., Alonso A. Sphingomyelinases: enzymology and membrane activity. FEBS Lett. 2002, 531:38-46.
30. H. Grassmé, J. Riethmüller, E. Gulbins, Biological aspects of ceramide- enriched membrane domains, Prog. Lipid Res. 46 (2007) 161-170.
31. Krönke M. Biophysics of ceramide signaling: interaction with proteins and phase transition of membranes. Chem. Phys. Lipids 1999, 101:109-121.
32. Pucadyil T.J., Chattopadhyay A. Exploring detergent insolubility in bovine hippocampal membranes: a critical assessment of the requirement for cholesterol. Biochim. Biophys. Acta 2004, 1661:9-17.
33. Brown R.E. Sphingolipid organization in biomembranes: what physical studies of model membranes reveal. J. Cell Sci. 1998, 111:1-9.
34. 1A receptors. Biochemistry 2010, 49:2389-2397.
35. 1A receptor. Biochem. Biophys. Res. Commun. 2011, 411:180-184.
36. Hanada K., Hara T., Fukasawa M., Yamaji A., Umeda M., Nishijima M. Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase. J. Biol. Chem. 1998, 273:33787-33794.
37. Ostrom R.S., Insel P.A. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br. J. Pharmacol. 2004, 143:235-245.
38. 1A receptors from bovine hippocampus. Biochim. Biophys. Acta 2004, 1663:188-200.
39. Pucadyil T.J., Chattopadhyay A. Role of cholesterol in the function and organization of G-protein coupled receptors. Prog. Lipid Res. 2006, 45:295-333.
40. Paila Y.D., Chattopadhyay A. Membrane cholesterol in the function and organization of G-protein coupled receptors. Subcell. Biochem. 2010, 51:439-466.