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Volumn 32, Issue 1, 2012, Pages 39-48

Hypercoagulation and thrombophilia in nonalcoholic fatty liver disease: Mechanisms, human evidence, therapeutic implications, and preventive implications

Author keywords

coagulopathy; hepatitis; steatohepatitis; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ANTIVITAMIN K;

EID: 84857955363     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0032-1306425     Document Type: Review
Times cited : (43)

References (121)
  • 2
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease: A global perspective
    • Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis: 2008; 28 4 339 350
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 3
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams CD, Stengel J, Asike MI., et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology: 2011; 140 1 124 131
    • (2011) Gastroenterology , vol.140 , Issue.1 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 4
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • DOI 10.1053/j.gastro.2007.03.059, PII S0016508507005859
    • Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology: 2007; 132 6 2169 2180 (Pubitemid 46693756)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 5
    • 77954424925 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: A community-based cohort study
    • Adams LA, Harmsen S, St Sauver JL., et al. Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study. Am J Gastroenterol: 2010; 105 7 1567 1573
    • (2010) Am J Gastroenterol , vol.105 , Issue.7 , pp. 1567-1573
    • Adams, L.A.1    Harmsen, S.2    St Sauver, J.L.3
  • 6
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA: 2010; 303 3 235 241
    • (2010) JAMA , vol.303 , Issue.3 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 8
    • 44449109670 scopus 로고    scopus 로고
    • NASH predicts plasma inflammatory biomarkers independently of visceral fat in men
    • DOI 10.1038/oby.2008.64, PII OBY200864
    • Targher G, Bertolini L, Rodella S., et al. NASH predicts plasma inflammatory biomarkers independently of visceral fat in men. Obesity (Silver Spring): 2008; 16 6 1394 1399 (Pubitemid 351770539)
    • (2008) Obesity , vol.16 , Issue.6 , pp. 1394-1399
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Lippi, G.4    Franchini, M.5    Zoppini, G.6    Muggeo, M.7    Day, C.P.8
  • 9
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med: 2000; 343 20 1467 1476
    • (2000) N Engl J Med , vol.343 , Issue.20 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 10
    • 77951063159 scopus 로고    scopus 로고
    • Disorders of coagulation and hemostasis in abdominal obesity: Emerging role of fatty liver
    • Targher G, Zoppini G, Moghetti P, Day CP. Disorders of coagulation and hemostasis in abdominal obesity: emerging role of fatty liver. Semin Thromb Hemost: 2010; 36 1 41 48
    • (2010) Semin Thromb Hemost , vol.36 , Issue.1 , pp. 41-48
    • Targher, G.1    Zoppini, G.2    Moghetti, P.3    Day, C.P.4
  • 11
    • 49449083979 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake
    • Thuy S, Ladurner R, Volynets V., et al. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr: 2008; 138 8 1452 1455
    • (2008) J Nutr , vol.138 , Issue.8 , pp. 1452-1455
    • Thuy, S.1    Ladurner, R.2    Volynets, V.3
  • 12
    • 67649170396 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome
    • Targher G, Chonchol M, Miele L, Zoppini G, Pichiri I, Muggeo M. Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome. Semin Thromb Hemost: 2009; 35 3 277 287
    • (2009) Semin Thromb Hemost , vol.35 , Issue.3 , pp. 277-287
    • Targher, G.1    Chonchol, M.2    Miele, L.3    Zoppini, G.4    Pichiri, I.5    Muggeo, M.6
  • 14
    • 0030015663 scopus 로고    scopus 로고
    • Liver steatosis and its relation to plasma haemostatic factors in apparently healthy men - Role of the metabolic syndrome
    • Cigolini M, Targher G, Agostino G, Tonoli M, Muggeo M, De Sandre G. Liver steatosis and its relation to plasma haemostatic factors in apparently healthy menrole of the metabolic syndrome. Thromb Haemost: 1996; 76 1 69 73 (Pubitemid 26254319)
    • (1996) Thrombosis and Haemostasis , vol.76 , Issue.1 , pp. 69-73
    • Cigolini, M.1    Targher, G.2    Agostino, G.3    Tonoli, M.4    Muggeo, M.5    De Sandre, G.6
  • 15
    • 34247636128 scopus 로고    scopus 로고
    • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C
    • DOI 10.1016/j.jhep.2007.01.021, PII S0168827807000700
    • Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C. Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C. J Hepatol: 2007; 46 6 1126 1132 (Pubitemid 46669732)
    • (2007) Journal of Hepatology , vol.46 , Issue.6 , pp. 1126-1132
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Arcaro, G.5    Day, C.6
  • 16
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • DOI 10.2337/dc06-2247
    • Targher G, Bertolini L, Padovani R., et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care: 2007; 30 5 1212 1218 (Pubitemid 46684650)
    • (2007) Diabetes Care , vol.30 , Issue.5 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Tessari, R.5    Zenari, L.6    Day, C.7    Arcaro, G.8
  • 17
    • 34547673500 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients
    • DOI 10.2337/dc07-0349
    • Targher G, Bertolini L, Rodella S., et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care: 2007; 30 8 2119 2121 (Pubitemid 47219432)
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 2119-2121
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Tessari, R.4    Zenari, L.5    Lippi, G.6    Arcaro, G.7
  • 18
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med: 2010; 363 14 1341 1350
    • (2010) N Engl J Med , vol.363 , Issue.14 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 19
    • 70349770695 scopus 로고    scopus 로고
    • Epidemiology and natural history of non-alcoholic steatohepatitis
    • Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis: 2009; 13 4 511 531
    • (2009) Clin Liver Dis , vol.13 , Issue.4 , pp. 511-531
    • Argo, C.K.1    Caldwell, S.H.2
  • 20
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    • DOI 10.1053/j.gastro.2007.11.038, PII S0016508507021154
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology: 2008; 134 2 424 431 (Pubitemid 351173050)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 21
    • 0036207720 scopus 로고    scopus 로고
    • Apolipoprotein synthesis in nonalcoholic steatohepatitis
    • DOI 10.1053/jhep.2002.32527
    • Charlton M, Sreekumar R, Rasmussen D, Lindor K, Nair KS. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology: 2002; 35 4 898 904 (Pubitemid 34258385)
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 898-904
    • Charlton, M.1    Sreekumar, R.2    Rasmussen, D.3    Lindor, K.4    Nair K.Sreekumaran5
  • 22
    • 70349249503 scopus 로고    scopus 로고
    • Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis
    • Fujita K, Nozaki Y, Wada K., et al. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology: 2009; 50 3 772 780
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 772-780
    • Fujita, K.1    Nozaki, Y.2    Wada, K.3
  • 23
    • 44949095286 scopus 로고    scopus 로고
    • Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis
    • DOI 10.1080/07853890801946515, PII 791848574
    • Musso G, Gambino R, De Michieli F., et al. Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis. Ann Med: 2008; 40 5 383 394 (Pubitemid 351882891)
    • (2008) Annals of Medicine , vol.40 , Issue.5 , pp. 383-394
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Biroli, G.4    Faga, E.5    Pagano, G.6    Cassader, M.7
  • 24
    • 49649118638 scopus 로고    scopus 로고
    • Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100
    • Ohsaki Y, Cheng J, Suzuki M, Fujita A, Fujimoto T. Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci: 2008; 121 Pt 14 2415 2422
    • (2008) J Cell Sci , vol.121 , Issue.PART 14 , pp. 2415-2422
    • Ohsaki, Y.1    Cheng, J.2    Suzuki, M.3    Fujita, A.4    Fujimoto, T.5
  • 25
    • 77956269092 scopus 로고    scopus 로고
    • Hepatocellular ballooning in NASH
    • Caldwell S, Ikura Y, Dias D., et al. Hepatocellular ballooning in NASH. J Hepatol: 2010; 53 4 719 723
    • (2010) J Hepatol , vol.53 , Issue.4 , pp. 719-723
    • Caldwell, S.1    Ikura, Y.2    Dias, D.3
  • 26
    • 33645236732 scopus 로고    scopus 로고
    • Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: Impact on disease progression
    • Ikura Y, Ohsawa M, Suekane T., et al. Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression. Hepatology: 2006; 43 3 506 514
    • (2006) Hepatology , vol.43 , Issue.3 , pp. 506-514
    • Ikura, Y.1    Ohsawa, M.2    Suekane, T.3
  • 27
    • 40949123364 scopus 로고    scopus 로고
    • Ballooned hepatocytes in steatohepatitis: The value of keratin immunohistochemistry for diagnosis
    • Lackner C, Gogg-Kamerer M, Zatloukal K, Stumptner C, Brunt EM, Denk H. Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. J Hepatol: 2008; 48 5 821 828
    • (2008) J Hepatol , vol.48 , Issue.5 , pp. 821-828
    • Lackner, C.1    Gogg-Kamerer, M.2    Zatloukal, K.3    Stumptner, C.4    Brunt, E.M.5    Denk, H.6
  • 28
    • 0028321941 scopus 로고
    • A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides
    • Itabe H, Takeshima E, Iwasaki H., et al. A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides. J Biol Chem: 1994; 269 21 15274 15279
    • (1994) J Biol Chem , vol.269 , Issue.21 , pp. 15274-15279
    • Itabe, H.1    Takeshima, E.2    Iwasaki, H.3
  • 29
    • 0033767987 scopus 로고    scopus 로고
    • Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity
    • Garca-Monzn C, Martn-Prez E, Iacono OL., et al. Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. J Hepatol: 2000; 33 5 716 724
    • (2000) J Hepatol , vol.33 , Issue.5 , pp. 716-724
    • Garca-Monzn, C.1    Martn-Prez, E.2    Iacono, O.L.3
  • 30
    • 14844288046 scopus 로고    scopus 로고
    • Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients
    • DOI 10.1016/j.jhep.2004.11.040
    • Malaguarnera L, Madeddu R, Palio E, Arena N, Malaguarnera M. Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. J Hepatol: 2005; 42 4 585 591 (Pubitemid 40342940)
    • (2005) Journal of Hepatology , vol.42 , Issue.4 , pp. 585-591
    • Malaguarnera, L.1    Madeddu, R.2    Palio, E.3    Arena, N.4    Malaguarnera, M.5
  • 31
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • DOI 10.1016/S0168-8278(02)00073-9, PII S0168827802000739
    • Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol: 2002; 37 1 56 62 (Pubitemid 34713055)
    • (2002) Journal of Hepatology , vol.37 , Issue.1 , pp. 56-62
    • Seki, S.1    Kitada, T.2    Yamada, T.3    Sakaguchi, H.4    Nakatani, K.5    Wakasa, K.6
  • 32
    • 21044437187 scopus 로고    scopus 로고
    • Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis
    • DOI 10.1136/gut.2004.057968
    • Albano E, Mottaran E, Vidali M., et al. Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis. Gut: 2005; 54 7 987 993 (Pubitemid 40873914)
    • (2005) Gut , vol.54 , Issue.7 , pp. 987-993
    • Albano, E.1    Mottaran, E.2    Vidali, M.3    Reale, E.4    Saksena, S.5    Occhino, G.6    Burt, A.D.7    Day, C.P.8
  • 33
    • 73149094543 scopus 로고    scopus 로고
    • The plasma lipidomic signature of nonalcoholic steatohepatitis
    • Puri P, Wiest MM, Cheung O., et al. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology: 2009; 50 6 1827 1838
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1827-1838
    • Puri, P.1    Wiest, M.M.2    Cheung, O.3
  • 35
    • 0032912640 scopus 로고    scopus 로고
    • Effects of native, triglyceride-enriched, and oxidatively modified LDL on plasminogen activator inhibitor-1 expression in human endothelial cells
    • Allison BA, Nilsson L, Karpe F, Hamsten A, Eriksson P. Effects of native, triglyceride-enriched, and oxidatively modified LDL on plasminogen activator inhibitor-1 expression in human endothelial cells. Arterioscler Thromb Vasc Biol: 1999; 19 5 1354 1360 (Pubitemid 29227658)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.5 , pp. 1354-1360
    • Allison, B.A.1    Nilsson, L.2    Karpe, F.3    Hamsten, A.4    Eriksson, P.5
  • 36
    • 0142124855 scopus 로고    scopus 로고
    • Oxidized phospholipids as modulators of inflammation in atherosclerosis
    • DOI 10.1097/00041433-200310000-00002
    • Leitinger N. Oxidized phospholipids as modulators of inflammation in atherosclerosis. Curr Opin Lipidol: 2003; 14 5 421 430 (Pubitemid 37297296)
    • (2003) Current Opinion in Lipidology , vol.14 , Issue.5 , pp. 421-430
    • Leitinger, N.1
  • 37
    • 0036096132 scopus 로고    scopus 로고
    • Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT
    • Bochkov VN, Mechtcheriakova D, Lucerna M., et al. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood: 2002; 99 1 199 206
    • (2002) Blood , vol.99 , Issue.1 , pp. 199-206
    • Bochkov, V.N.1    Mechtcheriakova, D.2    Lucerna, M.3
  • 38
    • 33645403083 scopus 로고    scopus 로고
    • Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes
    • Sommeijer DW, Hansen HR, van Oerle R., et al. Soluble tissue factor is a candidate marker for progression of microvascular disease in patients with Type 2 diabetes. J Thromb Haemost: 2006; 4 3 574 580
    • (2006) J Thromb Haemost , vol.4 , Issue.3 , pp. 574-580
    • Sommeijer, D.W.1    Hansen, H.R.2    Van Oerle, R.3
  • 39
    • 43949108922 scopus 로고    scopus 로고
    • The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity
    • DOI 10.1002/hep.22183
    • Li Z, Berk M, McIntyre TM, Gores GJ, Feldstein AE. The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity. Hepatology: 2008; 47 5 1495 1503 (Pubitemid 351702733)
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1495-1503
    • Li, Z.1    Berk, M.2    McIntyre, T.M.3    Gores, G.J.4    Feldstein, A.E.5
  • 40
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y., et al. Autophagy regulates lipid metabolism. Nature: 2009; 458 7242 1131 1135
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 41
    • 22344438075 scopus 로고    scopus 로고
    • Dying a thousand deaths: Redundant pathways from different organelles to apoptosis and necrosis
    • DOI 10.1053/j.gastro.2005.06.006, PII S0016508505011042
    • Lemasters JJ. Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis. Gastroenterology: 2005; 129 1 351 360 (Pubitemid 41002067)
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 351-360
    • Lemasters, J.J.1
  • 42
    • 79957493898 scopus 로고    scopus 로고
    • Microparticles in hemostasis and thrombosis
    • Owens AP III, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res: 2011; 108 10 1284 1297
    • (2011) Circ Res , vol.108 , Issue.10 , pp. 1284-1297
    • Owens III, A.P.1    MacKman, N.2
  • 43
    • 80052270962 scopus 로고    scopus 로고
    • PPAR activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH
    • Baron M, Leroyer AS, Majd Z., et al. PPAR activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH. Atherosclerosis: 2011; 18 1 69 76
    • (2011) Atherosclerosis , vol.18 , Issue.1 , pp. 69-76
    • Baron, M.1    Leroyer, A.S.2    Majd, Z.3
  • 45
    • 4644305245 scopus 로고    scopus 로고
    • Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: Role of visceral fat accumulation
    • DOI 10.2337/diacare.27.10.2498
    • Targher G, Bertolini L, Padovani R, Zenari L, Zoppini G, Falezza G. Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation. Diabetes Care: 2004; 27 10 2498 2500 (Pubitemid 39281410)
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2498-2500
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Zenari, L.4    Zoppini, G.5    Falezza, G.6
  • 47
    • 50849096389 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review
    • Sookoian S, Pirola CJ. Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol: 2008; 49 4 600 607
    • (2008) J Hepatol , vol.49 , Issue.4 , pp. 600-607
    • Sookoian, S.1    Pirola, C.J.2
  • 49
    • 37549047145 scopus 로고    scopus 로고
    • Fatty liver: A novel component of the metabolic syndrome
    • Kotronen A, Yki-Järvinen H. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol: 2008; 28 1 27 38
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.1 , pp. 27-38
    • Kotronen, A.1    Yki-Järvinen, H.2
  • 50
    • 33644700376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients
    • DOI 10.2337/diabetes.54.12.3541
    • Targher G, Bertolini L, Poli F., et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes: 2005; 54 12 3541 3546 (Pubitemid 43334347)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3541-3546
    • Targher, G.1    Bertolini, L.2    Poli, F.3    Rodella, S.4    Scala, L.5    Tessari, R.6    Zenari, L.7    Falezza, G.8
  • 52
    • 24044476188 scopus 로고    scopus 로고
    • Sonographic fatty liver, overweight and ischemic heart disease
    • Lin YC, Lo HM, Chen JD. Sonographic fatty liver, overweight and ischemic heart disease. World J Gastroenterol: 2005; 11 31 4838 4842
    • (2005) World J Gastroenterol , vol.11 , Issue.31 , pp. 4838-4842
    • Lin, Y.C.1    Lo, H.M.2    Chen, J.D.3
  • 55
    • 72949097025 scopus 로고    scopus 로고
    • Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels
    • Haring R, Wallaschofski H, Nauck M, Dörr M, Baumeister SE, Völzke H. Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology: 2009; 50 5 1403 1411
    • (2009) Hepatology , vol.50 , Issue.5 , pp. 1403-1411
    • Haring, R.1    Wallaschofski, H.2    Nauck, M.3    Dörr, M.4    Baumeister, S.E.5    Völzke, H.6
  • 56
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Söderberg C, Stl P, Askling J., et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology: 2010; 51 2 595 602
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 595-602
    • Söderberg, C.1    Stl, P.2    Askling, J.3
  • 57
    • 50549084740 scopus 로고    scopus 로고
    • Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease
    • Ong JP, Pitts A, Younossi ZM. Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol: 2008; 49 4 608 612
    • (2008) J Hepatol , vol.49 , Issue.4 , pp. 608-612
    • Ong, J.P.1    Pitts, A.2    Younossi, Z.M.3
  • 58
    • 58849134985 scopus 로고    scopus 로고
    • Long-term follow-up of patients with nonalcoholic fatty liver
    • Rafiq N, Bai C, Fang Y., et al. Long-term follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol: 2009; 7 2 234 238
    • (2009) Clin Gastroenterol Hepatol , vol.7 , Issue.2 , pp. 234-238
    • Rafiq, N.1    Bai, C.2    Fang, Y.3
  • 60
    • 84858285827 scopus 로고    scopus 로고
    • Nash increases the risk of portal vein thrombosis in patients on the liver transplant waiting list
    • abstract
    • Forssen U, Kobayashi M, Moylan CA, Ludema CM, Theodore D. Nash increases the risk of portal vein thrombosis in patients on the liver transplant waiting list. Hepatology: 2010; 52 4 911a 911a, abstract
    • (2010) Hepatology , vol.52 , Issue.4
    • Forssen, U.1    Kobayashi, M.2    Moylan, C.A.3    Ludema, C.M.4    Theodore, D.5
  • 61
    • 37549049764 scopus 로고    scopus 로고
    • Hypercoagulation and thrombophilia in liver disease
    • Coagulation in Liver Disease Group
    • Northup PG, Sundaram V, Fallon MB., et al. Coagulation in Liver Disease Group. Hypercoagulation and thrombophilia in liver disease. J Thromb Haemost: 2008; 6 1 2 9
    • (2008) J Thromb Haemost , vol.6 , Issue.1 , pp. 2-9
    • Northup, P.G.1    Sundaram, V.2    Fallon, M.B.3
  • 64
    • 71249149460 scopus 로고    scopus 로고
    • Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease
    • Bhagat V, Mindikoglu AL, Nudo CG, Schiff ER, Tzakis A, Regev A. Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. Liver Transpl: 2009; 15 12 1814 1820
    • (2009) Liver Transpl , vol.15 , Issue.12 , pp. 1814-1820
    • Bhagat, V.1    Mindikoglu, A.L.2    Nudo, C.G.3    Schiff, E.R.4    Tzakis, A.5    Regev, A.6
  • 65
    • 0019004240 scopus 로고
    • Quick: Pioneer and prophet of coagulation research
    • Dirckx JH, Armand J. Quick: pioneer and prophet of coagulation research. Ann Intern Med: 1980; 92 4 553 558
    • (1980) Ann Intern Med , vol.92 , Issue.4 , pp. 553-558
    • Dirckx, J.H.1    Armand, J.2
  • 66
    • 34250845810 scopus 로고    scopus 로고
    • Review article: The prothrombin time test as a measure of bleeding risk and prognosis in liver disease
    • DOI 10.1111/j.1365-2036.2007.03369.x
    • Tripodi A, Caldwell SH, Hoffman M, Trotter JF, Sanyal AJ. Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease. Aliment Pharmacol Ther: 2007; 26 2 141 148 (Pubitemid 46985499)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.2 , pp. 141-148
    • Tripodi, A.1    Caldwell, S.H.2    Hoffman, M.3    Trotter, J.F.4    Sanyal, A.J.5
  • 67
    • 54049100776 scopus 로고    scopus 로고
    • Interlaboratory variability in assessment of the model of end-stage liver disease score
    • Lisman T, van Leeuwen Y, Adelmeijer J., et al. Interlaboratory variability in assessment of the model of end-stage liver disease score. Liver Int: 2008; 28 10 1344 1351
    • (2008) Liver Int , vol.28 , Issue.10 , pp. 1344-1351
    • Lisman, T.1    Van Leeuwen, Y.2    Adelmeijer, J.3
  • 68
    • 34248674643 scopus 로고    scopus 로고
    • Changes in international normalized ratio (INR) and Model for Endstage Liver Disease (MELD) based on selection of clinical laboratory
    • DOI 10.1111/j.1600-6143.2007.01822.x
    • Trotter JF, Olson J, Lefkowitz J, Smith AD, Arjal R, Kenison J. Changes in international normalized ratio (INR) and model for endstage liver disease (MELD) based on selection of clinical laboratory. Am J Transplant: 2007; 7 6 1624 1628 (Pubitemid 46776260)
    • (2007) American Journal of Transplantation , vol.7 , Issue.6 , pp. 1624-1628
    • Trotter, J.F.1    Olson, J.2    Lefkowitz, J.3    Smith, A.D.4    Arjal, R.5    Kenison, J.6
  • 69
    • 79960241376 scopus 로고    scopus 로고
    • The coagulopathy of chronic liver disease
    • Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med: 2011; 365 2 147 156
    • (2011) N Engl J Med , vol.365 , Issue.2 , pp. 147-156
    • Tripodi, A.1    Mannucci, P.M.2
  • 70
    • 3142742615 scopus 로고    scopus 로고
    • Evaluation of liver fibrosis: A concise review
    • DOI 10.1111/j.1572-0241.2004.30110.x
    • Afdhal NH, Nunes D. Evaluation of liver fibrosis: a concise review. Am J Gastroenterol: 2004; 99 6 1160 1174 (Pubitemid 38917824)
    • (2004) American Journal of Gastroenterology , vol.99 , Issue.6 , pp. 1160-1174
    • Afdhal, N.H.1    Nunes, D.2
  • 75
    • 18144440602 scopus 로고    scopus 로고
    • Progress in the understanding of the protein C anticoagulant pathway
    • Dahlbäck B. Progress in the understanding of the protein C anticoagulant pathway. Int J Hematol: 2004; 79 2 109 116 (Pubitemid 38281808)
    • (2004) International Journal of Hematology , vol.79 , Issue.2 , pp. 109-116
    • Dahlback, B.1
  • 76
    • 70649100102 scopus 로고    scopus 로고
    • An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    • Tripodi A, Primignani M, Chantarangkul V., et al. An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology: 2009; 137 6 2105 2111
    • (2009) Gastroenterology , vol.137 , Issue.6 , pp. 2105-2111
    • Tripodi, A.1    Primignani, M.2    Chantarangkul, V.3
  • 77
    • 33747179530 scopus 로고    scopus 로고
    • No evidence for an intrinsic platelet defect in patients with liver cirrhosis - Studies under flow conditions [1]
    • DOI 10.1111/j.1538-7836.2006.02122.x
    • Lisman T, Adelmeijer J, de Groot PG, Janssen HL, Leebeek FW. No evidence for an intrinsic platelet defect in patients with liver cirrhosisstudies under flow conditions. J Thromb Haemost: 2006; 4 9 2070 2072 (Pubitemid 44226796)
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , Issue.9 , pp. 2070-2072
    • Lisman, T.1    Adelmeijer, J.2    De Groot, P.G.3    Janssen, H.L.A.4    Leebeek, F.W.G.5
  • 80
    • 0030461052 scopus 로고    scopus 로고
    • Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients
    • DOI 10.1097/00000542-199612000-00012
    • Despotis GJ, Levine V, Filos KS., et al. Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. Anesthesiology: 1996; 85 6 1311 1323 (Pubitemid 27014658)
    • (1996) Anesthesiology , vol.85 , Issue.6 , pp. 1311-1323
    • Despotis, G.J.1    Levine, V.2    Filos, K.S.3    Santoro, S.A.4    Joist, J.H.5    Spitznagel, E.6    Goodnough, L.T.7
  • 81
    • 0026698019 scopus 로고
    • Thrombelastography
    • Mallett SV, Cox DJ. Thrombelastography. Br J Anaesth: 1992; 69 3 307 313
    • (1992) Br J Anaesth , vol.69 , Issue.3 , pp. 307-313
    • Mallett, S.V.1    Cox, D.J.2
  • 82
    • 0029616068 scopus 로고
    • Thromboelastography and cardiopulmonary bypass
    • Spiess BD. Thromboelastography and cardiopulmonary bypass. Semin Thromb Hemost: 1995; 21 Suppl 4 27 33 (Pubitemid 26015178)
    • (1995) Seminars in Thrombosis and Hemostasis , vol.21 , Issue.SUPPL. 4 , pp. 27-33
    • Spiess, B.D.1
  • 84
    • 38649088635 scopus 로고    scopus 로고
    • Coagulation abnormalities in cirrhotic patients with portal vein thrombosis
    • Amitrano L, Guardascione MA, Ames PR. Coagulation abnormalities in cirrhotic patients with portal vein thrombosis. Clin Lab: 2007; 53 9-12 583 589 (Pubitemid 351166424)
    • (2007) Clinical Laboratory , vol.53 , Issue.11-12 , pp. 583-589
    • Amitrano, L.1    Guardascione, M.A.2    Ames, P.R.J.3
  • 85
    • 60749116711 scopus 로고    scopus 로고
    • Risk of venous thromboembolism in patients with liver disease: A nationwide population-based case-control study
    • Sgaard KK, Horvth-Puh E, Grnbaek H, Jepsen P, Vilstrup H, Srensen HT. Risk of venous thromboembolism in patients with liver disease: a nationwide population-based case-control study. Am J Gastroenterol: 2009; 104 1 96 101
    • (2009) Am J Gastroenterol , vol.104 , Issue.1 , pp. 96-101
    • Sgaard, K.K.1    Horvth-Puh, E.2    Grnbaek, H.3    Jepsen, P.4    Vilstrup, H.5    Srensen, H.T.6
  • 87
    • 77956194800 scopus 로고    scopus 로고
    • Anticoagulation for portal vein thrombosis in cirrhosis
    • author reply e21
    • Qi X, Han G, Wu K, Fan D. Anticoagulation for portal vein thrombosis in cirrhosis. Am J Med: 2010; 123 9 e19 e20, author reply e21
    • (2010) Am J Med , vol.123 , Issue.9
    • Qi, X.1    Han, G.2    Wu, K.3    Fan, D.4
  • 88
    • 0037046655 scopus 로고    scopus 로고
    • Aspirin for primary prevention of coronary events
    • DOI 10.1056/NEJMcp012672
    • Lauer MS. Clinical practice. Aspirin for primary prevention of coronary events. N Engl J Med: 2002; 346 19 1468 1474 (Pubitemid 34755716)
    • (2002) New England Journal of Medicine , vol.346 , Issue.19 , pp. 1468-1474
    • Lauer, M.S.1
  • 89
    • 0035892035 scopus 로고    scopus 로고
    • A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke
    • Warfarin-Aspirin Recurrent Stroke Study Group
    • Mohr JP, Thompson JL, Lazar RM., et al. Warfarin-Aspirin Recurrent Stroke Study Group. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med: 2001; 345 20 1444 1451
    • (2001) N Engl J Med , vol.345 , Issue.20 , pp. 1444-1451
    • Mohr, J.P.1    Thompson, J.L.2    Lazar, R.M.3
  • 90
    • 0015402321 scopus 로고
    • Abnormal aspirin metabolism in patients with cirrhosis and its possible relationship to bleeding in cirrhotics
    • Menguy R, Desbaillets L, Okabe S, Masters YF. Abnormal aspirin metabolism in patients with cirrhosis and its possible relationship to bleeding in cirrhotics. Ann Surg: 1972; 176 3 412 418
    • (1972) Ann Surg , vol.176 , Issue.3 , pp. 412-418
    • Menguy, R.1    Desbaillets, L.2    Okabe, S.3    Masters, Y.F.4
  • 91
    • 0019138151 scopus 로고
    • Plasma aspirin esterases in normal individuals, patients with alcholic liver disease and rheumatoid arthritis: Characterization and the importance of the enzymic components
    • Rainsford KD, Ford NL, Brooks PM, Watson HM. Plasma aspirin esterases in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterization and the importance of the enzymic components. Eur J Clin Invest: 1980; 10 5 413 420 (Pubitemid 11225574)
    • (1980) European Journal of Clinical Investigation , vol.10 , Issue.5 , pp. 413-420
    • Rainsford, K.D.1    Ford, N.L.V.2    Brooks, P.M.3    Watson, H.M.4
  • 94
    • 15744378579 scopus 로고    scopus 로고
    • A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women
    • Ridker PM, Cook NR, Lee IM., et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med: 2005; 352 13 1293 1304
    • (2005) N Engl J Med , vol.352 , Issue.13 , pp. 1293-1304
    • Ridker, P.M.1    Cook, N.R.2    Lee, I.M.3
  • 97
    • 80055031101 scopus 로고    scopus 로고
    • Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: A 12-month randomized, prospective, open- label trial
    • Torres DM, Jones FJ, Shaw JC, Williams CD, Ward JA, Harrison SA. Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial. Hepatology: 2011; 54 5 1631 1639
    • (2011) Hepatology , vol.54 , Issue.5 , pp. 1631-1639
    • Torres, D.M.1    Jones, F.J.2    Shaw, J.C.3    Williams, C.D.4    Ward, J.A.5    Harrison, S.A.6
  • 98
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • NASH CRN
    • Sanyal AJ, Chalasani N, Kowdley KV., et al. NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med: 2010; 362 18 1675 1685
    • (2010) N Engl J Med , vol.362 , Issue.18 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 99
    • 77958100236 scopus 로고    scopus 로고
    • A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis
    • Adams LA, Angulo P, Petz J, Keach J, Lindor KD. A pilot trial of high-dose ursodeoxycholic acid in nonalcoholic steatohepatitis. Hepatol Int: 2010; 4 3 628 633
    • (2010) Hepatol Int , vol.4 , Issue.3 , pp. 628-633
    • Adams, L.A.1    Angulo, P.2    Petz, J.3    Keach, J.4    Lindor, K.D.5
  • 100
    • 77953368192 scopus 로고    scopus 로고
    • The effect of metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): A pilot trial
    • Shields WW, Thompson KE, Grice GA, Harrison SA, Coyle WJ. The effect of metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): a pilot trial. Therap Adv Gastroenterol: 2009; 2 3 157 163
    • (2009) Therap Adv Gastroenterol , vol.2 , Issue.3 , pp. 157-163
    • Shields, W.W.1    Thompson, K.E.2    Grice, G.A.3    Harrison, S.A.4    Coyle, W.J.5
  • 101
    • 57549107354 scopus 로고    scopus 로고
    • Pioglitazone versus vitamin e versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
    • NASH CRN Research Group
    • Chalasani NP, Sanyal AJ, Kowdley KV., et al. NASH CRN Research Group. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials: 2009; 30 1 88 96
    • (2009) Contemp Clin Trials , vol.30 , Issue.1 , pp. 88-96
    • Chalasani, N.P.1    Sanyal, A.J.2    Kowdley, K.V.3
  • 102
    • 33847706491 scopus 로고    scopus 로고
    • Pioglitazone in nonalcoholic steatohepatitis
    • author reply 1068-1069
    • Targher G. Pioglitazone in nonalcoholic steatohepatitis. N Engl J Med: 2007; 356 10 1067, author reply 1068-1069
    • (2007) N Engl J Med , vol.356 , Issue.10 , pp. 1067
    • Targher, G.1
  • 105
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • DOI 10.1111/j.1572-0241.2003.08699.x
    • Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol: 2003; 98 11 2485 2490 (Pubitemid 37448761)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 106
    • 0029048868 scopus 로고
    • Hepatic and portal vein thrombosis in cirrhosis: Possible role in development of parenchymal extinction and portal hypertension
    • Wanless IR, Wong F, Blendis LM, Greig P, Heathcote EJ, Levy G. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology: 1995; 21 5 1238 1247
    • (1995) Hepatology , vol.21 , Issue.5 , pp. 1238-1247
    • Wanless, I.R.1    Wong, F.2    Blendis, L.M.3    Greig, P.4    Heathcote, E.J.5    Levy, G.6
  • 107
    • 73149088198 scopus 로고    scopus 로고
    • Fibrosis progression in chronic hepatitis C: Morphometric image analysis in the HALT-C trial
    • HALT-C Trial Group
    • Goodman ZD, Stoddard AM, Bonkovsky HL., et al. HALT-C Trial Group. Fibrosis progression in chronic hepatitis C: morphometric image analysis in the HALT-C trial. Hepatology: 2009; 50 6 1738 1749
    • (2009) Hepatology , vol.50 , Issue.6 , pp. 1738-1749
    • Goodman, Z.D.1    Stoddard, A.M.2    Bonkovsky, H.L.3
  • 108
    • 77950201652 scopus 로고    scopus 로고
    • Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection
    • Farglitizar Study Investigators., 1373, e1-e2
    • McHutchison J, Goodman Z, Patel K., et al. Farglitizar Study Investigators. Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection. Gastroenterology: 2010; 138 4 1365 1373, 1373, e1-e2
    • (2010) Gastroenterology , vol.138 , Issue.4 , pp. 1365-1373
    • McHutchison, J.1    Goodman, Z.2    Patel, K.3
  • 109
    • 33646011268 scopus 로고    scopus 로고
    • Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection
    • Muir AJ, Sylvestre PB, Rockey DC. Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection. J Viral Hepat: 2006; 13 5 322 328
    • (2006) J Viral Hepat , vol.13 , Issue.5 , pp. 322-328
    • Muir, A.J.1    Sylvestre, P.B.2    Rockey, D.C.3
  • 111
    • 47649093322 scopus 로고    scopus 로고
    • Coagulation status modulates murine hepatic fibrogenesis: Implications for the development of novel therapies
    • DOI 10.1111/j.1538-7836.2008.03015.x
    • Anstee QM, Goldin RD, Wright M, Martinelli A, Cox R, Thursz MR. Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies. J Thromb Haemost: 2008; 6 8 1336 1343 (Pubitemid 352016314)
    • (2008) Journal of Thrombosis and Haemostasis , vol.6 , Issue.8 , pp. 1336-1343
    • Anstee, Q.M.1    Goldin, R.D.2    Wright, M.3    Martinelli, A.4    Cox, R.5    Thursz, M.R.6
  • 113
    • 79955940888 scopus 로고    scopus 로고
    • Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease
    • Ibrahim M, Farghaly E, Gomaa W, Kelleni M, Abdelrahman AM. Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease. Eur J Pharmacol: 2011; 659 2-3 289 295
    • (2011) Eur J Pharmacol , vol.659 , Issue.23 , pp. 289-295
    • Ibrahim, M.1    Farghaly, E.2    Gomaa, W.3    Kelleni, M.4    Abdelrahman, A.M.5
  • 114
    • 34247258487 scopus 로고    scopus 로고
    • The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis
    • DOI 10.1007/s10620-006-9595-1
    • Assy N, Hussein O, Khalil A., et al. The beneficial effect of aspirin and enoxaparin on fibrosis progression and regenerative activity in a rat model of cirrhosis. Dig Dis Sci: 2007; 52 5 1187 1193 (Pubitemid 46626191)
    • (2007) Digestive Diseases and Sciences , vol.52 , Issue.5 , pp. 1187-1193
    • Assy, N.1    Hussein, O.2    Khalil, A.3    Luder, A.4    Szvalb, S.5    Paizi, M.6    Spira, G.7
  • 116
    • 1842531895 scopus 로고    scopus 로고
    • Factor V Leiden as a Risk Factor for Cirrhosis in Chronic Hepatitis C [3]
    • DOI 10.1002/hep.20166
    • Poujol-Robert A, Bolle PY, Poupon R, Robert A. Factor V. Factor V Leiden as a risk factor for cirrhosis in chronic hepatitis C. Hepatology: 2004; 39 4 1174 1175 (Pubitemid 38428958)
    • (2004) Hepatology , vol.39 , Issue.4 , pp. 1174-1175
    • Poujol-Robert, A.1    Boelle, P.-Y.2    Poupon, R.3    Robert, A.4
  • 118
    • 0043066540 scopus 로고    scopus 로고
    • Effects of heparin on liver fibrosis in patients with chronic hepatitis B
    • Shi J, Hao JH, Ren WH, Zhu JR. Effects of heparin on liver fibrosis in patients with chronic hepatitis B. World J Gastroenterol: 2003; 9 7 1611 1614 (Pubitemid 36992367)
    • (2003) World Journal of Gastroenterology , vol.9 , Issue.7 , pp. 1611-1614
    • Shi, J.1    Hao, J.-H.2    Ren, W.-H.3    Zhu, J.-R.4
  • 119
    • 70349732866 scopus 로고    scopus 로고
    • Thrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease
    • Papatheodoridis GV, Chrysanthos N, Cholongitas E., et al. Thrombotic risk factors and liver histologic lesions in non-alcoholic fatty liver disease. J Hepatol: 2009; 51 5 931 938
    • (2009) J Hepatol , vol.51 , Issue.5 , pp. 931-938
  • 120
    • 80052550368 scopus 로고    scopus 로고
    • Anticoagulation for liver fibrosis: A pilot study in hepatitis C infected patients
    • Dhar A, Anstee QM, Cobbold JF., et al. Anticoagulation for liver fibrosis: a pilot study in hepatitis C infected patients. Hepatology: 2010; 52 4 1133a 1133a
    • (2010) Hepatology , vol.52 , Issue.4
    • Dhar, A.1    Anstee, Q.M.2    Cobbold, J.F.3
  • 121
    • 76049092739 scopus 로고    scopus 로고
    • New concepts of coagulation and bleeding in liver disease
    • Northup PG, Caldwell SH. New concepts of coagulation and bleeding in liver disease. Intern Emerg Med: 2010; 5 1 3 6
    • (2010) Intern Emerg Med , vol.5 , Issue.1 , pp. 3-6
    • Northup, P.G.1    Caldwell, S.H.2


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