The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 10, 2012, Pages 3778-3783

  Adams, Cassandra J ^a   Pike, Ashley C W ^b   Maniam, Sandra ^a   Sharpe, Timothy D ^b   Coutts, Amanda S ^a   Knapp, Stefan ^b   La Thangue, Nicholas B ^a   Bullock, Alex N ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Crystal; DNA damage; p300; Stress; Tumor suppressor

Indexed keywords

OLIGONUCLEOTIDE; OLIGOSACCHARIDE; PROTEIN P53; STRESS RESPONSIVE ACTIVATOR OF P300 PROTEIN; TETRATRICOPEPTIDE REPEAT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TETRATRICOPEPTIDE REPEAT;

AMINO ACID MOTIFS; ANIMALS; CARRIER PROTEINS; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DNA DAMAGE; E1A-ASSOCIATED P300 PROTEIN; GENES, P53; HUMANS; MICE; MODELS, MOLECULAR; NEOPLASM PROTEINS; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; TUMOR SUPPRESSOR PROTEIN P53;

ATAXIA TELANGIECTASIA;

EID: 84857938174     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113731109     Document Type: Article

References (31)

1. Levine AJ, Oren M (2009) The first 30 years of p53: Growing ever more complex. Nat Rev Cancer 9:749-758.
2. Murray-Zmijewski F, Slee EA, Lu X (2008) A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol 9:702-712.
3. Brooks CL, Gu W (2006) p53 ubiquitination: Mdm2 and beyond. Mol Cell 21:307-315. (Pubitemid 43163526)
4. Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP (2009) Awakening guardian angels: Drugging the p53 pathway. Nat Rev Cancer 9:862-873.
5. Vousden KH, Prives C (2009) Blinded by the light: The growing complexity of p53. Cell 137(3):413-431.
6. Demonacos C, Krstic-Demonacos M, La Thangue NB (2001) A TPR motif cofactor contributes to p300 activity in the p53 response. Mol Cell 8:71-84. (Pubitemid 32772906)
7. Demonacos C, et al. (2004) A new effector pathway links ATM kinase with the DNA damage response. Nat Cell Biol 6:968-976. (Pubitemid 39359849)
8. Adams CJ, et al. (2008) ATM and Chk2 kinase target the p53 cofactor Strap. EMBO Rep 9:1222-1229.
9. Shikama N, et al. (1999) A novel cofactor for p300 that regulates the p53 response. Mol Cell 4:365-376. (Pubitemid 29499789)
10. Coutts AS, Weston L, La Thangue NB (2009) A transcription co-factor integrates cell adhesion and motility with the p53 response. Proc Natl Acad Sci USA 106:19872-7.
11. JanssonM, et al. (2008) Arginine methylation regulates the p53 response. Nat Cell Biol 10:1431-1439.
12. Xu D, Zalmas LP, La Thangue NB (2008) A transcription cofactor required for the heatshock response. EMBO Rep 9:662-669. (Pubitemid 351927687)
13. D'Andrea LD, Regan L (2003) TPR proteins: The versatile helix. Trends Biochem Sci 28:655-662. (Pubitemid 37500900)
14. Wang J, Dye BT, Rajashankar KR, Kurinov I, Schulman BA (2009) Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Nat Struct Mol Biol 16:987-989.
15. Holm L, Rosenstrom P (2010) Dali server: Conservation mapping in 3D. Nucleic Acids Res 38(Suppl):W545-549.
16. Arcus V (2002) OB-fold domains: a snapshot of the evolution of sequence, structure and function. Curr Opin Struct Biol 12:794-801.
17. Fletcher RJ, et al. (2003) The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol 10:160-167. (Pubitemid 36297984)
18. Davies L, et al. (2011) Regulation of glucocorticoid receptor activity by a stress responsive transcriptional cofactor. Mol Endocrinol 25:58-71.
19. Jimenez JL, Hegemann B, Hutchins JR, Peters JM, Durbin R (2007) A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database. Genome biology 8:R90.
20. Flynn RL, Zou L (2010) Oligonucleotide/oligosaccharide-binding fold proteins: A growing family of genome guardians. Crit Rev Biochem Mol Biol 45:266-275.
21. Coutts AS, La Thangue NB (2005) The p53 response: Emerging levels of co-factor complexity. Biochem Biophys Res Commun 331:778-785. (Pubitemid 40615508)
22. Leslie AGW (2006) The integration of macromolecular diffraction data. Acta Crystallogr D Biol Crystallogr 62:48-57.
23. Evans P (2006) Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr 62:72-82.
24. Collaborative Computational Project Number 4 (1994) The CCP4 Suite-Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr, 50 pp:760-763.
25. Sheldrick GM (2008) A short history of SHELX. Acta Crystallogr A 64:112-122.
26. Emsley P, Lohkamp B, Scott WG, Cowtan K (2010) Features and development of Coot. Acta Crystallogr D Biol Crystallogr 66:486-501.
27. Murshudov GN, Vagin AA, Dodson EJ (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53:240-255. (Pubitemid 27235885)
28. Milton AH, Khaire N, Ingram L, O'Donnell AJ, La Thangue NB (2006) 14-3-3 proteins integrate E2F activity with the DNA damage response. EMBO J 25:1046-1057. (Pubitemid 43372118)
29. Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299.
30. Kastan MB, et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587-597.
31. Zalmas LP, et al. (2008) DNA-damage response control of E2F7 and E2F8. EMBO Rep 9:252-259.