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The structure of the cell-puncturing machinery used by T4 phage places this structure in a cryo-electron microscopy map of the base plate-tail tube assembly. The OB-fold at the head of the puncturing 'needle' may play a role in binding to the peptidoglycan layer of the target cell.
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A classic example of structural homology linking proteins of similar function in the absence of sequence similarity. This paper reports the NMR structure of the yeast TEBP Cdc13. It shows that the TEBPs from distantly related eukaryotes share the OB-fold and bind telomere ends in similar ways.
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Mitton-Fry R.M., Anderson E.M., Hughes T.R., Lundblad V., Wuttke D.S. Conserved structure for single-stranded telomeric DNA recognition. Science. 296:2002;145-147. A classic example of structural homology linking proteins of similar function in the absence of sequence similarity. This paper reports the NMR structure of the yeast TEBP Cdc13. It shows that the TEBPs from distantly related eukaryotes share the OB-fold and bind telomere ends in similar ways.
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BRCA2 function and recombination from a BRCA2-DSS1-ssDNA structure
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Yang H., Jeffery P.D., Miller J., Kinnucan E., Sun Y., Thoma N.H., Zheng N., Chen P.-L., Lee W.-H., Pavletich N.P. BRCA2 function and recombination from a BRCA2-DSS1-ssDNA structure. Science. 297:2002;1837-1848.
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(2002)
Science
, vol.297
, pp. 1837-1848
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Yang, H.1
Jeffery, P.D.2
Miller, J.3
Kinnucan, E.4
Sun, Y.5
Thoma, N.H.6
Zheng, N.7
Chen, P.-L.8
Lee, W.-H.9
Pavletich, N.P.10
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