Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice

Toxicological Sciences

Volumn 126, Issue 1, 2012, Pages 227-241

  Nakamura, Brooke N ^a,c   Mohar, Isaac ^b,e   Lawson, Gregory W ^c   Cortés, Mabel M ^d   Hoang, Yvonne D ^a,f   Ortiz, Laura ^a   Patel, Reshma ^a   Rau, Bogdan A ^a   Mcconnachie, Lisa A ^b   Kavanagh, Terrance J ^b   Luderer, Ulrike ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Benzo a pyrene; Developmental toxicity; GCLM; Glutathione; PAH; Spermatogenesis

Indexed keywords

BENZO[A]PYRENE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS; EXPOSURE; GENE DELETION; GENE INACTIVATION; GESTATIONAL AGE; HISTOLOGY; MALE; MALE FERTILITY; MORPHOLOGY; MOUSE; NONHUMAN; ORGAN WEIGHT; PLACENTAL TRANSFER; PRENATAL EXPOSURE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS; TESTIS INJURY; TESTIS TOXICITY;

MUS;

EID: 84857929938     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs017     Document Type: Article

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