An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro

Molecular Genetics and Metabolism

Volumn 101, Issue 1, 2010, Pages 55-61

  Le, Truc M ^a   Willis, Alecia S ^b   Barr, Frederick E ^c,d   Cunningham, Gary R ^c,d   Canter, Jeffrey A ^d   Owens, Sarah E ^e   Apple, Rachel K ^d   Ayodo, George ^f   Reich, David ^f   Summar, Marshall L ^g  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Ethnic; Expression; Functional; Glutathione; Malaria; Oxidant injury; Polymorphism; Glutamylcysteine

Indexed keywords

CASPASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

462S GENE; AFRICAN AMERICAN; APOPTOSIS; ARTICLE; DNA POLYMORPHISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ETHNICITY; EUKARYOTE; GENE; GENE FREQUENCY; GENE OVEREXPRESSION; GENOTYPE; HUMAN; HUMAN CELL; NONHUMAN; P462S GENE; PRIORITY JOURNAL; PROKARYOTE;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 77955657972     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2010.05.013     Document Type: Article

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