Ethnic diversity in a critical gene responsible for glutathione synthesis

Free Radical Biology and Medicine

Volumn 34, Issue 1, 2003, Pages 72-76

  Willis, Alecia S ^a   Freeman, Michael L ^b   Summar, Samantha R ^c   Barr, Frederick E ^c   Williams, Scott M ^d   Dawson, Elliott ^e   Summar, Marshall L ^a,c,f  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d MEHARRY MEDICAL COLLEGE   (United States)

^e BioVentures Inc   (United States)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Glutamylcysteine synthetase; Ethnicity; Free radicals; GCLC; Glutamate cysteine ligase; Glutathione; Oxidative stress; Polymorphisms

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

AFRICA; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DEMOGRAPHY; DNA FLANKING REGION; DNA POLYMORPHISM; ENZYME ACTIVE SITE; ETHNIC DIFFERENCE; ETHNOLOGY; EXON; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC CODE; GENETIC SCREENING; GLUTATHIONE METABOLISM; HUMAN; NORMAL HUMAN; POPULATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS; UNITED STATES;

ETHNIC GROUPS; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 12244253724     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)01178-4     Document Type: Article

References (18)

1. Meister A., Anderson M.E. Glutathione. Annu. Rev. Biochem. 52:1983;711-760.
2. Shi Z., Osei-Frimpong J., Kala G., Kala S.V., Barios R.J., Habib G.M., Lukin D.J., Danney C.M., Matzuk M.M., Lieberman M.W. Glutathione synthesis is essential for mouse development but not for cell growth. Proc. Natl. Acad. Sci. USA. 97:2000;5101-5106.
3. Dalton T.P., Dieter M.Z., Yang Y., Shertzer H.G., Nebert D.W. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem. Biophys. Res. Commun. 279:2000;324-329.
4. Commandeur J.N.M., Stijntjes G.J., Vermeulen N.P.E. Enzymes and transport systems involved in the formation and disposition of glutathione-S-conjugates role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol. Rev. 47:1995;271-330.
5. Hammond C.L., Lee T.K., Ballatori N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J. Hepatol. 34:2001;946-954.
6. Reid M., Jahoor F. Glutathione in disease. Curr. Opin. Clin. Nutr. Metab. Care. 4:2001;65-71.
7. Deneke S.M., Fanburg B.L. Regulation of cellular glutathione. Am. J. Physiol. 257:1989;L163-L173.
8. Sierra-Rivera E., Summar M.L., Dasouki M., Krishnamani M.R., Phillips J.A. 3rd, Freeman M.L. Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma-glutamylcysteine synthetase to human chromosome 6. Cytogenet. Cell Genet. 70:1995;278-279.
9. Tsuchiya K., Mulcahy R.T., Reid L.L., Disteche C.M., Kavanagh T.J. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Genomics. 30:1995;630-632.
10. Gipp J.J., Mulcahy R.T. Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene. Cytogenet. Cell Genet. 88:2000;130-132.
11. Sierra-Rivera E., Dasouki M., Summar M.L., Krishnamani M.R., Meredith M., Rao P.N., Phillips J.A. 3rd, Freeman M.L. Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21. Cytogenet. Cell Genet. 72:1996;252-254.
12. Rozet J.M., Gerber S., Perrault I., Calvas P., Souied E., Chatelin S., Viegas-Pequignot E., Molina-Gomez D., Munnich A., Kaplan J. Structure and refinement of the physical mapping of the gamma-glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma. Cytogenet. Cell Genet. 82:1998;91-94.
13. Walsh A.C., Li W., Rosen D.R., Lawrence D.A. Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamylcysteine synthetase, to chromosome 6p12 and characterization of a polymorphic repeat within its 5′ untranslated region. Cytogenet. Cell Genet. 75:1996;14-16.
14. Beutler E., Gelbart T. Kondo, T.; Matsunaga, A. T. The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. Blood. 94:1999;2890-2894.
15. Walsh A.C., Feulner J.A., Reilley A. Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel. Toxicol. Sci. 61:2001;218-223.
16. den Dunnen J.T., Antonarakis S.E. Mutation nomenclature extensions and suggestions to describe complex mutations a discussion. Hum. Mutat. 15:2000;7-12.
17. Muscat J.E., Kleinman W.A., Colosimo S., Czander A., Stellman S.D., Richie J.P. Comparison of glutathione (GSH) levels in healthy black and white smokers. Proc. Am. Assoc. Cancer. Res. 43:2002;404.
18. Soltaninassab S.R., Sekhar K.R., Meredith M.J., Freeman M.L. Multi-faceted regulation of gamma-glutmylcysteine synthetase. J. Cell. Physiol. 182:2000;163-170.