Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: Implications for genetic testing

Breast Cancer Research and Treatment

Volumn 132, Issue 1, 2012, Pages 87-95

  De Leeneer, Kim ^a   Coene, Ilse ^a   Crombez, Brecht ^a   Simkens, Justine ^a   Van Den Broecke, Rudy ^a   Bols, Alain ^d   Stragier, Barbara ^b   Vanhoutte, Ilse ^c   De Paepe, Anne ^a   Poppe, Bruce ^a   Claes, Kathleen ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b Heilig Hart Ziekenhuis   (Belgium)

^c Department of Radiotherapy and Oncology   (Belgium)

^d Breast Clinic   (Belgium)

Author keywords

BRCA1 2; Breast and ovarian cancer; De novo mutation; Sporadic cancer

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3;

ADULT; AMINO ACID SEQUENCE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BELGIAN; BREAST CANCER; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; DNA EXTRACTION; ETHNICITY; FAMILY HISTORY; FEMALE; GENE DELETION; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; MALE; MICROSATELLITE MARKER; MOSAICISM; MUTATIONAL ANALYSIS; ONSET AGE; OVARY CANCER; PATERNITY TEST; PREVALENCE; PRIORITY JOURNAL;

ADULT; BASE SEQUENCE; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC TESTING; HEREDITARY BREAST AND OVARIAN CANCER SYNDROME; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS, SECOND PRIMARY; OVARIAN NEOPLASMS; PEDIGREE; YOUNG ADULT;

EID: 84857917249     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1544-9     Document Type: Article

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