Mediatophore regulates acetylcholine release from T cells

Journal of Neuroimmunology

Volumn 244, Issue 1-2, 2012, Pages 16-22

  Fujii, Takeshi ^a   Takada Takatori, Yuki ^a   Horiguchi, Kazuhide ^b   Kawashima, Koichiro ^c  

^a DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c MUSASHINO UNIVERSITY   (Japan)

Author keywords

Acetylcholine; Choline acetyltransferase; Mediatophore; Organic cation transporter; Vacuolar H + ATPase (V ATPase)

Indexed keywords

ACETYLCHOLINE; MEDIATOPHORE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SMALL INTERFERING RNA;

ACETYLCHOLINE RELEASE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE; UPREGULATION;

ACETYLCHOLINE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; MITOGENS; NERVE TISSUE PROTEINS; PHYTOHEMAGGLUTININS; RNA, SMALL INTERFERING; T-LYMPHOCYTES; UP-REGULATION;

EID: 84857911195     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.12.022     Document Type: Article

References (52)

1. Bloc A., Bugnard E., Dunant Y., Falk-Vairant J., Israël M., Loctin F., Roulet E. Acetylcholine synthesis and quantal release reconstituted by transfection of mediatophore and choline acetyltransferase cDNAs. Eur. J. Neurosci. 1999, 11:1523-1534.
2. Cavalli A., Eder-Colli L., Dunant Y., Loctin F., Morel N. Release of acetylcholine by Xenopus oocytes injected with mRNAs from cholinergic neurons. EMBO J. 1991, 10:1671-1675.
3. + antiport in rapid neurotransmission. Ann. N.Y. Acad. Sci. 2009, 1152:100-112.
4. En-Nosse M., Hartmann S., Trinkaus K., Alt V., Stigler B., Heiss C., Kilian O., Schnettler R., Lips K.S. Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis. Cell Tissue Res. 2009, 338:203-215.
5. Falk-Vairant J., Correges P., Eder-Colli L., Salem N., Roulet E., Bloc A., Meunier F., Lesbats B., Loctin F., Synguelakis M., Israel M., Dunant Y. Quantal acetylcholine release induced by mediatophore transfection. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:5203-5207.
6. Forgac M. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat. Rev. Mol. Cell Biol. 2007, 8:917-929.
7. Fujii T., Kawashima K. Calcium oscillation is induced by muscarinic acetylcholine receptor stimulation in human leukemic T- and B-cell lines. Naunyn Schmiedbergs Arch. Pharmacol. 2000, 362:14-21.
8. 3 muscarinic acetylcholine receptors in human T- and B-cells. Jpn. J. Pharmacol. 2000, 84:124-132.
9. 2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T-cells. Gen. Pharmacol. 2001, 35:71-75.
10. Fujii T., Tsuchiya T., Yamada S., Fujimoto K., Suzuki T., Kasahara T., Kawashima K. Localization and synthesis of acetylcholine in human leukemic T cell lines. J. Neurosci. Res. 1996, 44:66-72.
11. Fujii T., Yamada S., Watanabe Y., Misawa H., Tajima S., Fujimoto K., Kasahara T., Kawashima K. Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator. J. Neuroimmunol. 1998, 82:101-107.
12. Fujii T., Tajima S., Yamada S., Watanabe Y., Sato K.Z., Matsui M., Misawa H., Fujimoto K., Kasahara T., Kawashima K. Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines. Neurosci. Lett. 1999, 259:71-74.
13. Fujii T., Ushiyama N., Hosonuma K., Suenaga A., Kawashima K. Effects of human antithymocyte Globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line. J. Neuroimmunol. 2002, 128:1-8.
14. 5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses. Neurochem. Res. 2003, 28:423-429.
15. Fujii T., Takada-Takatori Y., Kawashima K. Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J. Pharmacol. Sci. 2008, 106:186-192.
16. Fujii T., Masai M., Misawa H., Okuda T., Takada-Takatori Y., Moriwaki Y., Haga T., Kawashima K. Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase. J. Neurosci. Res. 2009, 87:3024-3032.
17. Grando S.A., Kawashima K., Kirkpatrick C.J., Wessler I. Recent progress in understanding the non-neuronal cholinergic system in humans. Life Sci. 2007, 80:2181-2185.
18. Horiuchi Y., Fujii T., Kamimura Y., Kawashima K. The endogenous, immunologically active peptide apelin inhibits lymphocytic cholinergic activity during immunological responses. J. Neuroimmunol. 2003, 144:46-52.
19. Imboden B.J., Shoback M.D., Pattison G., Stobo D.J. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:5673-5677.
20. Israël M., Dunant Y. A unifying hypothesis for acetylcholine release. Neurochem. Int. 1996, 28:1-9.
21. Israël M., Dunant Y. Acetylcholine release and the cholinergic genomic locus. Mol. Neurobiol. 1998, 16:1-20.
22. Israël M., Morel N., Lesbats B., Birman S., Manaranche R. Purification of a presynaptic membrane protein that mediates a calcium-dependent translocation of acetylcholine. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:9226-9230.
23. Israël M., Lesbats B., Synguelakis M., Joliot A. Acetylcholine accumulation and release by hybrid NG108-15, glioma and neuroblastoma cells-role of a 16kDa membrane protein in release. Neurochem. Int. 1994, 25:103-109.
24. Israël M., Lesbats B., Tomasi M., Ohkuma S. Enhanced acetylcholine release from cells that have more15-kDa proteolipid in their membrane, a constituent V-ATPase, and mediatophore. J. Neurochem. 1998, 71:630-635.
25. +)-ATPases. Arch. Biochem. Biophys. 2008, 476:33-42.
26. Kawashima K., Fujii T. Extraneuronal cholinergic system in lymphocytes. Pharmacol. Ther. 2000, 86:29-48.
27. Kawashima K., Fujii T. The lymphocytic cholinergic system in lymphocytes. Life Sci. 2003, 74:675-696.
28. Kawashima K., Fujii T. Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front. Biosci. 2004, 9:2063-2085.
29. Kawashima K., Fujii T. Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance. J. Pharmacol. Sci. 2008, 106:167-173.
30. Kawashima K., Ishikawa H., Mochizuki M. Radioimmunoassay for acetylcholine in the rat brain. J. Pharmacol. Methods 1980, 3:115-123.
31. 2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line. Life Sci. 2003, 72:2155-2159.
32. Kirkpatrick C.J., Bittinger F., Nozadze K., Wessler I. Expression and function of the non-neuronal cholinergic system in endothelial cells. Life Sci. 2003, 72:2111-2116.
33. Kummer W., Wiegand S., Akinci S., Wessler I., Schnkel A.H., Wess J., Koepsell H., Haberberger R.V., Lips K.S. Role of acetylcholine and polyspecific cation transporters in serotonn-induced bronchoconstriction in the mouse. Respir. Res. 2006, 7:65-76.
34. Leroy C., Meunier F.M., Lesbats B., Israël M. In vitro expression of the 15 kDa subunit of the mediatophore and functional reconstitution of acetylcholine release. Gen. Pharmacol. 1994, 25:245-255.
35. Lips K.S., Volk C., Schmitt B.M., Pfeil U., Arndt P., Miska D., Ermert L., Kummer W., Koepsell H. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am. J. Respir. Cell Mol. Biol. 2005, 33:79-88.
36. Lips K.S., Wunsch J., Zarghooni S., Bschleipfer T., Schukowski K., Weidner W., Wessler I., Schwantes U., Koepsell H., Kummer W. Acetylcholine and molecular components of its synthesis and release machinery in the urothelium. Eur. Urol. 2007, 51:1042-1053.
37. Malo M., Israël M. Expression of the acetylcholine release mechanism in various cells and reconstruction of the release mechanism in non-releasing cells. Life Sci. 2003, 72:2029-2038.
38. Marshansky V., Futai M. The V-type-ATPase in vesicular trafficking: targeting, regulation and function. Curr. Opin. Cell Biol. 2008, 20:415-426.
39. Morel N. Neurotransmitter release: the dark side of the vacuolar-H+ATPase. Biol. Cell 2003, 95:453-457.
40. 0 sector of V-ATPase. J. Neurochem. 2001, 79:485-488.
41. +)-ATPases-nature's most versatile proton pumps. Nat. Rev. Mol. Cell Biol. 2002, 3:94-103.
42. Oosawa H., Fujii T., Kawashima K. Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells. J. Neurosci. Res. 1999, 57:381-387.
43. Proskocil B.J., Sekhon H.S., Jia Y., Savchenko V., Blakely R.D., Lindstrom J., Spindel E.R. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology 2004, 145:2498-2506.
44. Song P., Sekhon H.S., Jia Y., Keller J.A., Blusztajn J.K., Mark G.P., Spindel E.R. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res. 2003, 63:214-221.
45. 4 receptor agonist, in human leukemic T cells of the MOLT-3 line. Vasc. Pharmacol. 2004, 41:51-58.
46. Toei M., Saum R., Forgac M. Regulation and isolation function of the V-ATPases. Biochemistry 2010, 49:4715-4723.
47. Usdin T.B., Eiden L.E., Bonner T.I., Erickson J.D. Molecular biology of the vesicular ACh transporter. Trends Neurosci. 1995, 18:218-224.
48. Varoqui H., Erickson J.D. Active transport of acetylcholine by human vesicular acetylcholine transporter. J. Biol. Chem. 1996, 271:27229-27232.
49. Wessler I., Kirkpatrick C.J. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br. J. Pharmacol. 2008, 154:1558-1571.
50. Wessler I., Roth E., Deutsch C., Brockerhoff P., Bittinger F., Kirkpatrick C.J., Kilbinger H. Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br. J. Pharmacol. 2001, 134:951-956.
51. Wessler I., Herschel S., Bittinger F., Kirkpatrick C.J. Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants. Life Sci. 2007, 80:2210-2213.
52. Zhan H., Yokoyama K., Otani H., Tanigaki K., Shirota N., Takano S., Ohkuma S. Different roles of proteolipids and 70-kDa subunits of V-ATPase in growth and death of cultured human cells. Genes Cells 2003, 8:501-513.