Modeling nuclear blebs in a nucleoskeleton of independent filament networks

Cellular and Molecular Bioengineering

Volumn 5, Issue 1, 2012, Pages 73-81

  Wren, Nicholas S ^a,b   Zhong, Zhixia ^a   Schwartz, Russell S ^c   Dahl, Kris Noel ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Dysmorphism; Lamina; Mechanotransduction; Nuclear mechanics; Nucleoskeleton

Indexed keywords

ALPHAII SPECTRIN; LAMIN A; LAMIN B; SPECTRIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; MECHANOTRANSDUCTION; MOLECULAR DYNAMICS; NUCLEAR BLEB; NUCLEAR SHAPE; NUCLEOSKELETON; PRIORITY JOURNAL;

EID: 84857904005     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-011-0196-5     Document Type: Article

References (32)

1. Aebi, U., J. Cohn, L. Buhle, and L. Gerace. The nuclear lamina is a meshwork of intermediate-type filaments. Nature 323:560-564, 1986. (Pubitemid 16025383)
2. Bell, G. I. Models for the specific adhesion of cells to cells. Science 200:618-627, 1978.
3. Boal, D. H. Mechanics of the Cell. Cambridge: Cambridge University Press, 2002; (p. xiv, 406 p).
4. Dahl, K. N., S. M. Kahn, K. L. Wilson, and D. E. Discher. The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. J. Cell Sci. 117:4779-4786, 2004. (Pubitemid 39433444)
5. Dahl, K. N., and A. Kalinowski. Nucleoskeleton mechanics at a glance. J. Cell Sci. 124:675-678, 2011.
6. Dahl, K. N., P. Scaffidi, M. F. Islam, A. G. Yodh, K. L. Wilson, T. Misteli, et al. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc. Natl Acad. Sci. USA 103:10271-10276, 2006. (Pubitemid 44051156)
7. Goldberg, M. W., I. Huttenlauch, C. J. Hutchison, and R. Stick. Filaments made from A- and B-type lamins differ in structure and organization. J. Cell Sci. 121:215-225, 2008. (Pubitemid 351228454)
8. Goldman, R. D., D. K. Shumaker, M. R. Erdos, M. Eriksson, A. E. Goldman, L. B. Gordon, Y. Gruenbaum, S. Khuon, M. Mendez, R. Varga, and F. S. Collins. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc. Natl Acad. Sci. USA 101:8963-8968, 2004. (Pubitemid 38781594)
9. Herrmann, H., and U. Aebi. Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds. Annu. Rev. Biochem. 73:749-789, 2004. (Pubitemid 39050385)
10. Herrmann, H., and R. Foisner. Intermediate filaments: novel assembly models and exciting new functions for nuclear lamins. Cell. Mol. Life Sci. 60:1607-1612, 2003. (Pubitemid 37041359)
11. Hohenadl, M., T. Storz, H. Kirpal, K. Kroy, and R. Merkel. Desmin filaments studied by quasi-elastic light scattering. Biophys. J. 77:2199-2209, 1999. (Pubitemid 29463180)
12. Holaska, J. M., K. L. Wilson, and M. Mansharamani. The nuclear envelope, lamins and nuclear assembly. Curr. Opin. Cell Biol. 14:357-364, 2002. (Pubitemid 34626975)
13. Janmey, P. A., U. Euteneuer, P. Traub, and M. Schliwa. Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J. Cell Biol. 113:155-160, 1991. (Pubitemid 21909682)
14. Lammerding, J., R. T. Lee, S. G. Young, C. L. Stewart, K. Reue, J. Y. Ji, L. G. Fong, et al. Lamins A and C but not lamin B1 regulate nuclear mechanics. J. Biol. Chem. 281:25768-25780, 2006. (Pubitemid 44401965)
15. Lammerding, J., P. C. Schulze, T. Takahashi, S. Kozlov, T. Sullivan, R. D. Kamm, C. L. Stewart, R. T. Lee, et al. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J. Clin. Invest. 113:370-378, 2004. (Pubitemid 38544181)
16. Leckband, D. Measuring the forces that control protein interactions. Annu. Rev. Biophys. Biomol. Struct. 29:1-26, 2000. (Pubitemid 30599586)
17. Lin, F., and H. J. Worman. Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J. Biol. Chem. 268:16321-16326, 1993. (Pubitemid 23229934)
18. Maniotis, A. J., C. S. Chen, and D. E. Ingber. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc. Natl Acad. Sci. USA 94:849-854, 1997. (Pubitemid 27074410)
19. Mellad, J. A., D. T. Warren, and C. M. Shanahan. Nesprins LINC the nucleus and cytoskeleton. Curr. Opin. Cell Biol. 23:47-54, 2010.
20. Meshorer, E., D. Yellajoshula, E. George, P. J. Scambler, D. T. Brown, and T. Misteli. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev. Cell 10:105-116, 2006. (Pubitemid 43025681)
21. Moir, R. D., M. Yoon, S. Khuon, and R. D. Goldman. Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells. J. Cell Biol. 151:1155-1168, 2000.
22. Muchir, A., J. Medioni, M. Laluc, C. Massart, T. Arimura, A. J. van der Kooi, I. Desguerre, M. Mayer, X. Ferrer, S. Briault, M. Hirano, H. J. Worman, A. Mallet, M. Wehnert, K. Schwartz, and G. Bonne. Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. Muscle Nerve 30:444-450, 2004. (Pubitemid 39288147)
23. Qin, Z., L. Kreplak, and M. J. Buehler. Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments. PLoS One 4:e7294, 2009.
24. Razafsky, D., and D. Hodzic. Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J. Cell Biol. 186:461-472, 2009.
25. Schopferer, M., H. Bar, B. Hochstein, S. Sharma, N. Mucke, H. Herrmann, and N. Willenbacher. Desmin and vimentin intermediate filament networks: their viscoelastic properties investigated by mechanical rheometry. J. Mol. Biol. 388:133-143, 2009.
26. Shimi, T., K. Pfleghaar, S. Kojima, C. G. Pack, I. Solovei, A. E. Goldman, S. A. Adam, D. K. Shumaker, M. Kinjo, T. Cremer, and R. D. Goldman. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. Genes Dev. 22:3409-3421, 2008.
27. Taimen, P., K. Pfleghaar, T. Shimi, D. Moller, K. Ben-Harush, M. R. Erdos, S. A. Adam, H. Herrmann, O. Medalia, F. S. Collins, A. E. Goldman, and R. D. Goldman.Aprogeria mutation reveals functions for laminA in nuclear assembly, architecture, and chromosome organization. Proc. Natl Acad. Sci. USA 106:20788-20793, 2009.
28. Vaziri, A., and M. R. Mofrad. Mechanics and deformation of the nucleus in micropipette aspiration experiment. J. Biomech. 40:2053-2062, 2007. (Pubitemid 46843002)
29. Wessels, D., E. Voss, N. Von Bergen, R. Burns, J. Stites, and D. R. Soll. A computer-assisted system for reconstructing and interpreting the dynamic three-dimensional relationships of the outer surface, nucleus and pseudopods of crawling cells. Cell Motil. Cytoskeleton 41:225-246, 1998. (Pubitemid 29077335)
30. Wydner, K. L., J. B. Lawrence, F. Lin, H. J. Worman, J. B. Lawrence, et al. Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. Genomics 32:474-478, 1996. (Pubitemid 26094354)
31. Young, K. G., and R. Kothary. Spectrin repeat proteins in the nucleus. Bioessays 27:144-152, 2005. (Pubitemid 40292386)
32. Zhong, Z., K. L. Wilson, and K. N. Dahl. Beyond lamins other structural components of the nucleoskeleton. Methods Cell Biol. 98:97-119, 2011.