A prostacycline analog prevents chronic myocardial remodeling in murine cardiac allografts

International Heart Journal

Volumn 53, Issue 1, 2012, Pages 64-67

  Suzuki, Jun ichi ^a   Ogawa, Masahito ^a   Sakai, Yoshiki ^b   Hirata, Yasunobu ^a   Isobe, Mitsuaki ^c   Nagai, Ryozo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Collagen; Inflammation; Prostacyclin; Transplantation

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXYACETIC ACID; COLLAGEN; CYTOKINE; ONO 1301MS; ONO 13101MS; PROSTACYCLIN DERIVATIVE; THROMBOXANE A2; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ALLOGRAFT; ANIMAL EXPERIMENT; ARTICLE; CHRONIC GRAFT REJECTION; CHRONIC MYOCARDIAL REMODELING; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; MALE; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; COLLAGEN; CYTOKINES; EPOPROSTENOL; GRAFT SURVIVAL; HEART TRANSPLANTATION; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYOCARDIUM; PYRIDINES; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS; VENTRICULAR REMODELING;

EID: 84857852456     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.53.64     Document Type: Article

References (22)

1. Stehlik J, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult heart transplant report--2010. J Heart Lung Transplant 2010; 29: 1089-103.
2. Suzuki J, Isobe M, Morishita R, Nagai R. Characteristics of chronic rejection in heart transplantation: important elements of pathogenesis and future treatments. Circ J 2010; 74: 233-9. (Review)
3. Takahashi Y, Tokuoka S, Masuda T, et al. Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Br J Pharmacol 2002; 137: 315-22.
4. Nagao K, Tanaka H, Komai M, Masuda T, Narumiya S, Nagai H. Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice. Am J Respir Cell Mol Biol 2003; 29: 314-20.
5. Idzko M, Hammad H, van Nimwegen M, et al. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest 2007; 117: 464-72.
6. Kataoka M, Nagaya N, Satoh T, et al. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Am J Respir Crit Care Med 2005; 172: 1575-80.
7. Imawaka H, Sugiyama Y. Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist. J Pharmacol Exp Ther 1998; 284: 949-57.
8. Hayashi K, Nagamatsu T, Oka T, Suzuki Y. Modulation of antiglomerular basement membrane nephritis in rats by ONO-1301, a non-prostanoid prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase. Jpn J Pharmacol 1997; 73: 73-82.
9. Rudd JA, Qian Y, Tsui KK, Jones RL. Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br J Pharmacol 2000; 129: 782-90.
10. Murakami S, Nagaya N, Itoh T, et al. Prostacycline agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2006; 290: L59-65.
11. Nakamura K, Sata M, Iwata H, et al. A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart. Clin Sci (Lond) 2007; 112: 607-16.
12. Iwata H, Nakamura K, Sumi M, et al. Local delivery of synthetic prostacycline agonist augments collateral growth and improves cardiac function in a swine chronic cardiac ischemia model. Life Sci 2009; 85: 255-61.
13. Suzuki J, Isobe M, Morishita R, et al. Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide. Nat Med 1997; 3: 900-3.
14. Suzuki J, Ogawa M, Sagesaka YM, Isobe M. Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts. Cardiovasc Res 2006; 69: 272-9.
15. Suzuki J, Koga N, Kosuge H, et al. Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts. Transplantation 2007; 83: 1093-7.
16. Ogawa M, Suzuki J, Hishikari K, Takayama K, Tanaka H, Isobe M. Clarithromycin attenuates acute and chronic rejection via matrix metalloproteinase suppression in murine cardiac transplantation. J Am Coll Cardiol 2008; 51: 1977-85.
17. Stegemann H, Stalder K. Determination of hydroxyproline. Clin Chim Acta 1967; 18: 267-73. (Review)
18. Zhou W, Hashimoto K, Goleniewska K, et al. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol 2007; 178: 702-10.
19. Suzuki J, Morishita R, Amano J, Kaneda Y, Isobe M. Decoy against nuclear factor-kappa B attenuates myocardial cell infiltration and arterial neointimal formation in murine cardiac allografts. Gene Ther 2000; 7: 1847-52.
20. Wei L. Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis. Exp Mol Pathol 2011; 90: 74-8. (Review)
21. Hirata Y, Soeki T, Akaike M, Sakai Y, Igarashi T, Sata M. Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters. Biomed Pharmacother 2009; 63: 781-6.
22. Obata H, Sakai Y, Ohnishi S, et al. Single injection of a sustainedrelease prostacyclin analog improves pulmonary hypertension in rats. Am J Respir Crit Care Med 2008; 177: 195-201.