Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 3, 1998, Pages 949-957

  Imawaka, Haruo ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDRO 5 [2 [[ALPHA (3 PYRIDYL)BENZYLIDENE]AMINOOXY]ETHYL] 1 NAPHTHYLOXY]ACETIC ACID; ADENOSINE TRIPHOSPHATE; ANION; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; NEW DRUG; PLASMA PROTEIN; PRAVASTATIN; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; ROTENONE; SODIUM ION; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG LIVER LEVEL; DRUG STRUCTURE; DRUG TRANSPORT; INDUCED HYPOTHERMIA; INTRAVENOUS DRUG ADMINISTRATION; LIVER BLOOD FLOW; MALE; MATHEMATICAL MODEL; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ANIMALS; BILE; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; LIVER; LIVER CIRCULATION; MALE; METABOLIC CLEARANCE RATE; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN;

EID: 0031885828     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. + on bile acid uptake by isolated rat hepatocytes. Hoppe-Seyler's Z Physiol Chem 359:181-192.
2. Arias IM, Fleischner G, Kirsch R, Mishkin S and Gatmaitan Z (1976) On the structure, regulation, and function of ligandin, in Glutathione: Metabolism and Function (Arias IM and Jakoby WB, eds) pp 175, Raven Press, New York.
3. Baur H, Kasperek S and Pfaff E (1975) Criteria of viability of isolated liver cells. Heppe-Seyler's Z. Physiol Chem 356:827-838.
4. Chung YB, Miyauchi S, Sugiyama Y, Harashima H, Iga T and Hanano M (1990) Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate (ANS). J Hepatol 11:240-251.
5. Elferink RPJO, Meijer DKF, Kuipers F, Jansen PLM, Groan AK and Groothis GMM (1995) Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
6. +/bile acid cotransport system. Proc Natl Acad Sci USA 88:10629-10633.
7. +/bile acid cotransporter. J Clin Invest 93:1326-1331.
8. Inoue M, Kinne R, Tran T and Arias IM (1982) Taurocholate transport by rat liver sinusoidal membrane vesicles: Evidence of sodium co-transport. Hepatology 2:572-579.
9. Ishikawa T, Muller M, Klunemann C, Schaub T and Keppler D (1990) ATP-dependent primary active transport of cystenyl leukotrienes across liver canalicular membrane: Role of ATP-dependent transport system for glutatione S-conjugates. J Biol Chem 265:19279-19286.
10. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T and Sugiyama Y (1996) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272:G16-G22.
11. Iwatsubo T, Hirota N, Ooie T, Suzuki H and Sugiyama Y (1996) Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics. Biopharm Drug Dispos 17:273-310.
12. Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW and Meier PJ (1991) Expression of the hepatocellular chloride-dependent sulfobromophthalein uptake system in Xenopus laevis oocytes. J Clin Invest 88:2146-2149.
13. +/-independent organic anion transporter. Proc Natl Acad Sci, USA 91:133-137.
14. Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW and Schuster VL (1995) Identification and characterization of a prostaglandin transporter. Science 268:866-869.
15. Kirn DC, Sugiyama Y, Satoh H, Fuwa T, Iga T and Hanano M (1988) Kinetic analysis of in vivo receptor-dependent binding of human epidermal growth factor by rat tissues. J Pharm Sci 77:200-207.
16. Kobayashi K, Sogame Y, Hara H and Hayashi K (1990) Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membrane vesicles. J Biol Chem 265:7737-7741.
17. 2 mimetic with inhibitory activity against thromboxane synthase, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research (Samuelsson B, Ramwell PW, Paoletti R, Folco G, Granström E and Nicosia S, eds) vol 23, pp 401-403, Raven Press, Ltd., New York.
18. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schtengart CD, Hofmann AF, Wolkoff AW and Meier PJ (1995) Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver, Gastroenterology 109: 1274-1282.
19. Lin JH, Sugiyama Y, Awazu S and Hanano M (1980) Kinetic studies on the deethylation of ethoxybenzamide: A comparative study with isolated hepatocytes and liver microsomes of rats. Biochem Pharmacol 29:2826-2830.
20. Meijer DKF, Mol WEM, Muller M and Kurz G (1990) Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations. J Pharmacokinet Biopharm 18:35-70.
21. Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I and Keppler D (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 131:137-150.
22. Miyauchi S, Sugiyama Y, Sawada Y, Iga T and Hanano M (1987) Kinetics of hepatic transport of 4-methylumbelliferone in rats: Analysis by multiple indicator dilution method. J Pharrmacokinet Biopharm 15:25-38.
23. Miyauchi S, Sawada Y, Iga T, Hanano M and Sugiyama Y (1993) Comparison of the hepatic clearance of fifteen drugs with a wide range of membrane permeabilities determined using isolated rat hepatocytes and perfused rat livers. Pharmacol Res 10:434-440.
24. Nagata O, Murata M, Kato H, Terasaki T, Sato H and Tsuji A (1990) Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate. Drug Metab Dispos 18:902-910.
25. Pang KS and Gillette R (1978) Kinetics of metabolite formation and elimination in the perfused rat liver preparation: Difference between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. J Pharmacol Exp Ther 207:178-194.
26. Petzinger E (1994) Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport. Rev Physiol Biochem Pharmacol 123:47-211.
27. Roberts MS and Rowland M (1986) A dispersion model of hepatic elimination. 2. Steady state considerations. Influence of blood flow, protein binding and hepatocellular enzymatic activity. J Pharrmacokinet Biopharm 14:261-288.
28. Sathirakul K, Suzuki H, Yasuda K, Hanano M, Tagaya O, Horie T and Sugiyama Y (1993) Kinetic analysis of hepatobiliary transport of organic anions in eisai hyperbilirubinemic mutant rats. J Pharmacol Exp Ther 265:1301-1312.
29. Schwenk M (1980) Transport systems of isolated hepatocytes. Studies on the transport of biliary compounds. Arch Toxicol 44:113-126.
30. Sugita O, Sawada Y, Sugiyama Y, Iga T and Hanano M ( 1982 ) Physiologically based pharmacokinetics of drug-drug interaction: A study of tolubutamide-sulfonamide interaction in rats. J Pharmacokinet Biopharm 10:297-316.
31. Sugiyama Y, Yamada T and Kaplowitz N (1981) Glutathione S-transferase in elasmobranch liver: Molecular heterogeneity, catalytic and binding properties and purification, Biochem J 199:749-756.
32. Sugiyama Y, Yamada T and Kaplowitz N (1983) Newly identified bile acid binders in rat liver cytosol: Purification and comparison with glutathione S-transferases. J Biol Chem 258:3602-3607.
33. Tsao SC, Sugiyama Y, Shinmura K, Sawada Y, Nagase S, Iga T and Hanano M (1988) Protein mediated uptake of rose bengal in an albuminemic rats (NAR); Albumin is not indispensable to the protein mediated transport of rose bengal. Drug Metab Dispos 16:482-489.
34. Takenaka O, Horie T, Suzuki H, Kobayashi K and Sugiyama Y (1995) Kinetic analysis of hepatobiliary transport for conjugative metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugative hyperbilirubinemia. Pharmacol Res 12: 1746-1755.
35. von Dippe P, Amoui M, Stellwagen RH and Levy D (1996) The functional expression of sodium-dependent bile acid transport in Madin-Darby canine kidney cells transfected with the cDNA for microsomal epoxide hydrolase. J Biol Chem 271:18176-18180.
36. Watkins JB and Klaassen CD (1983) Chemically-induced alteration of UDP-glucuronic acid concentration in rat liver. Drug Metab Dispos 11:37-40.
37. Yamaoka K, Tanigawara Y, Nakagawa Y and Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn 4:879-885.
38. + -independent multispecific anion transporter mediates active transport of pravastatin into rat liver. Am J Physiol 264:G36-G44.
39. Yamazaki M, Suzuki H, Hanano M and Sugiyama Y (1993b) Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions. Am J Physiol 264:G693-G701.
40. Yamazaki M, Suzuki H and Sugiyama Y ( 1996) Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics: Pharmacol Res 13:497-513.
41. Yanai M, Sugiyama Y, Iga T, Fuwa T and Hanano M (1990) Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo. Am J Physiol 258:C593-C598.
42. Yokota M, Iga T, Awazu S and Hanano M (1976) Simple method of hepatic venous blood sampling in the rat. J Appl Physiol 4:349-441.