DNA-binding activity of adeno-associated virus rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8

Journal of Virology

Volumn 86, Issue 5, 2012, Pages 2859-2863

  Alex, Martin ^a   Weger, Stefan ^a   Mietzsch, Mario ^a   Slanina, Heiko ^a,c   Cathomen, Toni ^a,b   Heilbronn, Regine ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INFECTED CELL PROTEIN 8; PROTEIN REP78; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ADENO ASSOCIATED VIRUS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HERPES SIMPLEX VIRUS; IN VITRO STUDY; IN VIVO STUDY; INVERTED TERMINAL REPEAT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; VIRUS GENOME; VIRUS REPLICATION;

BINDING SITES; DEPENDOVIRUS; DNA HELICASES; DNA REPLICATION; DNA-BINDING PROTEINS; HELA CELLS; HELPER VIRUSES; HUMANS; PARVOVIRIDAE INFECTIONS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SIMPLEXVIRUS; TERMINAL REPEAT SEQUENCES; VIRAL PROTEINS; VIRUS REPLICATION;

ADENO-ASSOCIATED VIRUS; SIMPLEXVIRUS;

EID: 84857841890     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06364-11     Document Type: Article

References (37)

1. Boehmer PE, Craigie MC, Stow ND, Lehman IR. 1994. Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo. J. Biol. Chem. 269:29329-29334.
2. Chejanovsky N, Carter BJ. 1990. Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication. J. Virol. 64:1764-1770.
3. Chiorini JA, et al. 1994. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. J. Virol. 68:7448-7457.
4. Davis MD, Wonderling RS, Walker SL, Owens RA. 1999. Analysis of the effects of charge cluster mutations in adeno-associated virus Rep68 protein in vitro. J. Virol. 73:2084-2093.
5. Davis MD, Wu J, Owens RA. 2000. Mutational analysis of adenoassociated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates. J. Virol. 74:2936-2942.
6. Di Pasquale G, Stacey SN. 1998. Adeno-associated virus Rep78 protein interacts with protein kinase A and its homolog PRKX and inhibits CREBdependent transcriptional activation. J. Virol. 72:7916-7925.
7. Dudas KC, Ruyechan WT. 1998. Identification of a region of the herpes simplex virus single-stranded DNA-binding protein involved in cooperative binding. J. Virol. 72:257-265.
8. Han SI, et al. 2004. Rep68 protein of adeno-associated virus type 2 interacts with 14-3-3 proteins depending on phosphorylation at serine 535. Virology 320:144-155.
9. Heilbronn R, Bürkle A, Stephan S, zur Hausen H. 1990. The adenoassociated virus rep gene suppresses herpes simplex virus-induced DNAamplification. J. Virol. 64:3012-3018.
10. Heilbronn R, et al. 2003. ssDNA-dependent colocalization of adenoassociated virus Rep and herpes simplex virus ICP8 in nuclear replication domains. Nucleic Acids Res. 31:6206-6213.
11. Hickman AB, Ronning DR, Kotin RM, Dyda F. 2002. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol. Cell 10:327-337.
12. Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. 2004. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol. Cell 13: 403-414.
13. Hörer M, et al. 1995. Mutational analysis of adeno-associated virus Rep. protein-mediated inhibition of heterologous and homologous promoters. J. Virol. 69:5485-5496.
14. Im D-S, Muzyczka N. 1990. The AAV origin-binding protein Rep68 is an ATP-dependent site-specific endonuclease with helicase activity. Cell 61: 447-457.
15. Im D-S, Muzyczka N. 1989. Factors that bind to adeno-associated virus terminal repeats. J. Virol. 63:3095-3104.
16. Im D-S, Muzyczka N. 1992. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization. J. Virol. 66:1119-1128.
17. Kleinschmidt JA, Möhler M, Weindler F, Heilbronn R. 1995. Sequence elements of the adeno-associated virus rep-gene required for suppression of herpes-simplex virus induced DNA amplification. Virology 206:254-262.
18. Makhov AM, Boehmer PE, Lehman IR, Griffith JD. 1996. Visualization of the unwinding of long DNA chains by the herpes simplex virus type 1 UL9 protein and ICP8. J. Mol. Biol. 258:789-799.
19. Mansilla-Soto J, et al. 2009. DNA structure modulates the oligomerization properties of the AAV initiator protein Rep68. PLoS Pathog. 5:e1000513.
20. Mapelli M, Mühleisen M, Persico G, van der Zandt H, Tucker PA. 2000. The 60-residue C-terminal region of the single-stranded DNA binding protein of herpes simplex virus type 1 is required for cooperative DNA binding. J. Virol. 74:8812-8822.
21. Mapelli M, Panjikar S, Tucker PA. 2005. The crystal structure of the herpes simplex virus 1 ssDNA-binding protein suggests the structural basis for flexible, cooperative single-stranded DNA binding. J. Biol. Chem. 280:2990-2997.
22. McCarty DM, Ryan JH, Zolotukhin S, Zhou X, Muzyczka N. 1994. Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat. J. Virol. 68:4998-5006.
23. Owens RA, Trempe JP, Chejanovsky N, Carter BJ. 1991. Adenoassociated virus rep proteins produced in insect and mammalian expression systems: wild-type and dominant-negative mutant proteins bind to the viral replication origin. Virology 184:14-22.
24. Owens RA, Weitzman MD, Kyöstiö SRM, Carter BJ. 1993. Identification of a DNA-binding domain in the amino terminus of adenoassociated virus Rep proteins. J. Virol. 67:997-1005.
25. Ruyechan WT, Weir AC. 1984. Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA-binding protein. J. Virol. 52:727-733.
26. Schmidt M, Chiorini JA, Afione S, Kotin R. 2002. Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: fine mapping and analysis of mechanism. J. Virol. 76:1033-1042.
27. Slanina H, Weger S, Stow ND, Kuhrs A, Heilbronn R. 2006. Role of the herpes simplex virus helicase-primase complex during adeno-associated virus DNA replication. J. Virol. 80:5241-5250.
28. Snyder RO, et al. 1993. Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J. Virol. 67: 6096-6104.
29. Weger S, Hammer E, Heilbronn R. 2004. SUMO-1 modification regulates the protein stability of the large regulatory protein Rep78 of adeno associated virus type 2 (AAV-2). Virology 330:284-294.
30. Weger S, Hammer E, Heilbronn R. 2002. Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression. J. Gen. Virol. 83:511-516.
31. Weger S, Wendland M, Kleinschmidt J, Heilbronn R. 1999. The adenoassociated virus type 2 regulatory proteins Rep78/Rep68 interact with the transcriptional coactivator PC4. J. Virol. 73:260-269.
32. Weindler FW, Heilbronn R. 1991. A subset of herpes simplex virus replication genes provides helper functions for productive adenoassociated virus replication. J. Virol. 65:2476-2483.
33. Weitzman MD, Kyöstiö SRM, Carter BJ, Owens RA. 1996. Interaction of wild-type and mutant adeno-associated virus (AAV) Rep proteins on AAV hairpin DNA. J. Virol. 70:2440-2448.
34. Weitzman MD, Kyöstiö SRM, Kotin RM, Owens RA. 1994. Adenoassociated virus (AAV) Rep. proteins mediate complex formation between AAVDNAand its integration site in human DNA. Proc. Natl. Acad. Sci. U. S. A. 91:5808-5812.
35. Wonderling RS, Kyostio SR, Owens RA. 1995. A maltose-binding protein/adeno-associated virus Rep68 fusion protein has DNA-RNA helicase and ATPase activities. J. Virol. 69:3542-3548.
36. Yoon-Robarts M, et al. 2004. Residues within the B' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2. J. Biol. Chem. 279:50472-50481.
37. Young SM, Jr., McCarty DM, Degtyareva N, Samulski RJ. 2000. Roles of adeno-associated virus Rep. protein and human chromosome 19 in sitespecific recombination. J. Virol. 74:3953-3966.