Visualization of the unwinding of long DNA chains by the herpes simplex virus type 1 UL9 protein and ICP8

Journal of Molecular Biology

Volumn 258, Issue 5, 1996, Pages 789-799

  Makhov, Alexander M ^a,d   Boehmer, Paul E ^b,c   Lehman, I Robert ^b   Griffith, Jack D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b STANFORD UNIVERSITY   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^d D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

Author keywords

Electron microscopy; Helicase; Herpes simplex; ICP8; UL9

Indexed keywords

BINDING PROTEIN; HELICASE; INFECTED CELL PROTEIN 8; NUCLEOPROTEIN; UL9 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA DENATURATION; ELECTRON MICROSCOPY; HERPES SIMPLEX VIRUS 1; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STAINING;

EID: 0029902725     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0287     Document Type: Article

References (45)

1. Bayliss, G. J., Marsden, H. S. & Hay, J. (1975). Herpes simplex virus proteins: DNA-binding proteins in infected cells and in the virus structure. Virology, 68, 124-134.
2. Boehmer, P. E. & Lehman, I. R. (1993a). Herpes simplex virus type 1 ICP8: helix-destabilizing properties. J. Virol. 67, 711-715.
3. Boehmer, P. E. & Lehman, I. R. (1993b). Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8. Proc. Natl Acad. Sci. USA, 90, 8444-8448.
4. Boehmer, P. E., Dodson, M. S. & Lehman, I. R. (1993). The herpes simplex virus type-1 origin binding protein. DNA helicase activity. J. Biol. Chem. 268, 1220-1225.
5. Boehmer, P. E., Craigie, M. C., Stow, N. D. & Lehman, I. R. (1994). Association of origin binding protein and single strand DNA-binding protein, ICP8, during herpes simplex virus type 1 DNA replication in vivo. J. Biol. Chem. 269, 29329-29334.
6. Bortner, C., Hernandez, T. R., Lehman, I. R. & Griffith, J. (1993). Herpes simplex virus 1 single-strand DNA-binding protein (ICP8) will promote homologous pairing and strand transfer. J. Mol. Biol. 231, 241-250.
7. Bruckner, R. C., Crute, J. J., Dodson, M. S. & Lehman, I. R. (1991). The herpes simplex virus 1 origin binding protein: a DNA helicase. J. Biol. Chem. 266, 2669-2674.
8. Challberg, M. D. & Kelly T. J., (1989). Animal virus DNA replication. Annu. Rev. Biochem. 58, 671-717.
9. Crute, J. J., Elias, P. & Lehman, I. R. (1990). In Molecular Mechanisms of DNA Replication and Recombination, pp. 327-341, Alan R. Liss, Inc. New York.
10. De Bruyn Kops, A. & Knipe, D. M. (1988). Formation of DNA replication structures in herpes virus infected cells requires a viral DNA binding protein. Cell, 55, 857-868.
11. Dutch, R. E. & Lehman, I. R. (1993). Renaturation of complementary DNA strands by herpes simplex virus type-1 ICP8. J. Virol. 67, 6945-6949.
12. Elias, P. & Lehman, I. R. (1988). Interaction of origin binding protein with an origin of replication of herpes simplex virus 1. Proc. Natl Acad Sci. USA, 85, 2959-2963.
13. Elias, P., O'Donnell, M. E., Mocarski, E. S. & Lehman, I. R. (1986). A DNA binding protein specific for an origin of replication of herpes simplex virus type 1. Proc. Natl Acad. Sci. USA, 83, 6322-6326.
14. Fierer, D. S. & Challberg, M. D. (1992). Purification and characterization of UL9, the herpes simplex virus type 1 origin-binding protein. J. Virol. 66, 3986-3995.
15. Gao, M. & Knipe, D. M. (1991). Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression. J. Virol. 65, 2666-2675.
16. Godowski, P. J. & Knipe, D. M. (1986). Transcriptional control for herpes virus gene expression: gene functions required for positive and negative regulation. Proc. Natl Acad. Sci. USA, 83, 256-260.
17. Gorbalenya, A. E., Koonin, E. V., Donchenko, A. P. & Blinov, V. M. (1988). Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucl. Acids Res. 17, 4713-4730.
18. Griffith, J. D. & Christiansen, G. (1978). Electron microscope visualization of chromatin and other DNA-protein complexes. Annu. Rev. Biophys. Bioeng. 7, 19-37.
19. Griffith, J. D., Makhov, A., Zawel, L. & Reinberg, D. (1995). Visualization of TBP oligomers binding and bending the HIV-1 and adeno promoters. J. Mol. Biol. 246, 576-584.
20. Lee, C. K. & Knipe, D. M. (1985). An immunoassay for the study of DNA-binding activities of herpes simplex virus protein ICP8. J. Virol. 54, 731-738.
21. Lohman, T. M. (1992). Escherichia coli DNA helicases: mechanisms of DNA unwinding. Mol. Microbiol. 6, 5-14.
22. Lohman, T. M. (1993). Helicase-catalyzed DNA unwinding. J. Biol. Chem. 268, 2269-2272.
23. Lohman, T. M. & Bjornson, K. P. (1996). Mechansims of helicase-catalyzed DNA unwinding. Annu. Rev. Biochem. In the press.
24. Makhov, M., Boehmer, P. E., Lehman, I. R. & Griffith, J. D. (1996). The Herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms unwound stem/loop structures. EMBO J. In the press.
25. Martinez, R., Shao, L. & Weller, S. K. (1992). The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function. J. Virol. 66, 6735-6746.
26. McGeoch, D. J., Dalrymple, M. A., Dolan, A., McNab, D., Perry, L. J., Taylor, P. & Challberg, M. D. (1988). Structures of herpes simplex virus type 1 genes required for replication of virus DNA. J. Virol. 62, 444-453.
27. O'Donnell, M. E., Elias, P., Funnell, B. E. & Lehman, I. R. (1987). Interaction between the DNA polymerase and single-stranded DNA-binding protein (infected cell protein 8) of herpes simplex virus 1. J. Biol. Chem. 262, 4260-4266.
28. Olivo, P. D., Nelson, N. J. & Challberg, M. D. (1988). Herpes simplex virus DNA replication: the UL9 gene encodes an origin-binding protein. Proc. Natl Acad. Sci. USA, 85, 5414-5418.
29. Poll, E. H., Harrison, J., Umthun, A., Dobbs, D. L. & Benbow, R. M. (1994). Xenopus laevis ovarian DNA helicase I: a 3′ to 5′ helicase that unwinds short duplexes. Biochemistry, 33, 3841-3817.
30. Quinlan, M. P., Chen, L. B. & Knipe, D. M. (1984). The intranuclear location of a herpes viral DNA-binding protein is determined by the status of viral DNA replication. Cell, 36, 857-868.
31. Rabkin, S. D. & Hanlon, B. (1991). Nucleoprotein complex formed between herpes simplex virus UL9 protein and the origin of DNA replication: inter- and intramolecular interactions. Proc. Natl Acad. Sci. USA, 88, 10946-10950.
32. Ruyechan, W. T. (1983). The major herpes simplex virus DNA-binding protein holds single-stranded DNA in an extended configuration. J. Virol. 46, 661-666.
33. Ruyechan, W. T. & Weir, A. C. (1984). Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA-binding protein. J. Virol. 52, 727-733.
34. Seo, Y. S. & Hurwitz, J. (1993). Isolation of helicase alpha, a DNA helicase from HeLa cells stimulated by a fork structure and single-stranded DNA-binding proteins. J. Biol. Chem. 268, 10282-10295.
35. Smith, K. R., Yansey J. E. & Matson, S. W. (1989). Identification and purification of a protein that stimulates the helicase activity of the Escherichia coli Rep protein. J. Biol. Chem. 264, 6119-6126.
36. Steven, A. C., Trus, B. L., Maizel, J. V., Unser, M., Parry D. A. D., Wall, J. S., Hainfeld, J. F. & Studier, F. W. (1988). Molecular substructure of a viral receptor recognition protein. The gp17 tail-fiber of bacteriophage T7. J. Mol. Biol. 200, 351-365.
37. Stow, N. D., Hammarsten, O., Arbuckle, M. I. & Elias, P. (1993). Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein. Virology, 196, 413-418.
38. Umezu, K. & Nakayama, H. (1993). RecQ DNA helicase of Escherichia coli. Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein. J. Mol. Biol. 230, 1145-1150.
39. Villani, G., Pillaire, M.-J. & Boehmer, P. E. (1994). Effect of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II) on the activity of a helicase essential for DNA replication, the herpes simplex virus type-1 origin-binding protein. J. Biol. Chem. 269, 21676-21681.
40. Wang, Y-H., Howard, M. & Griffith, J. D. (1991). Phased adenine tracts in double-stranded RNA do not induce sequence-directed bending. Biochemistry, 30, 5443-5449.
41. Wessel, R., Muller, H. & Hoffmann-Berling, H. (1990a). Electron microscopy of DNA-helicase-I complexes in the act of strand separation. Eur. J. Biochem. 189, 277-285.
42. Wessel, R., Muller, H. & Hoffmann-Berling, H. (1990b). Electron microscopic analysis of DNA forks generated by Escherichia coli DNA helicase II. Eur. J. Biochem. 192, 695-701.
43. Wessel, R., Schweizer, J. & Stahl, H. (1992). Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J. Virol. 66, 804-815.
44. Wu, C. A., Nelson, N. J., McGeoch, D. J. & Challberg, M. D. (1988). Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. J. Virol. 62, 435-443.
45. Yancy-Wrona, J. E., Wood, E. R., George, J. W., Smith, K. P. & Matson S. W. (1992). Escherichia coli Rep protein and helicase IV. Distributive single-stranded DNA-dependent ATPases that catalyze a limited un-winding reaction in vitro. Eur. J. Biochem. 207, 479-485.