The axonal guidance receptor neogenin promotes acute inflammation

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  König, Klemens ^a,b   Gatidou, Dimitra ^a   Granja, Tiago ^a,b   Meier, Jens ^a,b   Rosenberger, Peter ^a   Mirakaj, Valbona ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; NEOGENIN; AUTACOID; CELL SURFACE RECEPTOR; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; AXONAL INJURY; BONE MARROW; CELL MIGRATION; CHIMERA; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNE SYSTEM; INFLAMMATION; LYMPHOCYTE; MOUSE; NERVE CELL GROWTH; NERVE FIBER; NERVOUS SYSTEM; NONHUMAN; PERITONITIS; PROTEIN ANALYSIS; ANIMAL; ANTIBODY SPECIFICITY; DRUG ANTAGONISM; GENE EXPRESSION; GENETICS; MALE; METABOLISM; MOUSE MUTANT;

ANIMALIA;

ANIMALS; CYTOKINES; GENE EXPRESSION; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PERITONITIS; RECEPTORS, CELL SURFACE;

EID: 84857822677     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032145     Document Type: Article

References (33)

1. Baggiolini M, (1998) Chemokines and leukocyte traffic. Nature 392: 565-568.
2. Baggiolini M, (2001) Chemokines in pathology and medicine. J Intern Med 250: 91-104.
3. Tessier-Lavigne M, Goodman CS, (1996) The molecular biology of axon guidance. Science 274: 1123-1133.
4. Yu TW, Bargmann CI, (2001) Dynamic regulation of axon guidance. Nat Neurosci 4 (Suppl): 1169-1176.
5. Muramatsu R, Kubo T, Mori M, Nakamura Y, Fujita Y, et al. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nat Med 17: 488-494.
6. Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, et al. (2009) Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 10: 195-202.
7. Wu JY, Feng LL, Park HT, Havlioglu N, Wen L, et al. (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410: 948-952.
8. Rao Y, Wong K, Ward M, Jurgensen C, Wu JY, (2002) Neuronal migration and molecular conservation with leukocyte chemotaxis. Genes & Development 16: 2973-2984.
9. Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, et al. (2007) Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 446: 680-684.
10. Kruger RP, Aurandt J, Guan KL, (2005) Semaphorins command cells to move. Nat Rev Mol Cell Biol 6: 789-800.
11. Mirakaj V, Brown S, Laucher S, Steinl C, Klein G, et al. (2011) Repulsive guidance molecule-A (RGM-A) inhibits leukocyte migration and mitigates inflammation. Proc Natl Acad Sci U S A 108: 6555-6560.
12. Gad JM, Keeling SL, Wilks AF, Tan SS, Cooper HM, (1997) The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. Dev Biol 192: 258-273.
13. Meyerhardt JA, Look AT, Bigner SH, Fearon ER, (1997) Identification and characterization of neogenin, a DCC-related gene. Oncogene 14: 1129-1136.
14. Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, et al. (2004) Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 6: 756-762.
15. Wilson NH, Key B, (2006) Neogenin interacts with RGMa and Netrin-1 to guide axons within the embryonic vertebrate forebrain. Developmental Biology 296: 485-498.
16. Koeberle PD, Tura A, Tassew N, Schlichter LC, Monnier PP, (2010) The repulsive guidance molecule, RGMa, promotes retinal ganglion cell survival in vitro and in vivo. Neuroscience.
17. Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, et al. (2004) RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 6: 749-755.
18. Zhou Z, Xie J, Lee D, Liu Y, Jung J, et al. (2010) Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation. Dev Cell 19: 90-102.
19. Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L, (2003) Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell 4: 371-382.
20. Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY, (2010) Netrin-4 induces lymphangiogenesis in vivo. Blood 115: 5418-5426.
21. Park KW, Crouse D, Lee M, Karnik SK, Sorensen LK, et al. (2004) The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A 101: 16210-16215.
22. Bae GU, Yang YJ, Jiang G, Hong M, Lee HJ, et al. (2009) Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro. Mol Biol Cell 20: 4920-4931.
23. Henes J, Schmit MA, Morote-Garcia JC, Mirakaj V, Kohler D, et al. (2009) Inflammation-associated repression of vasodilator-stimulated phosphoprotein (VASP) reduces alveolar-capillary barrier function during acute lung injury. Faseb J 23: 4244-4255.
24. Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ, (1994) Neogenin, an Avian Cell-Surface Protein Expressed during Terminal Neuronal Differentiation, Is Closely-Related to the Human Tumor-Suppressor Molecule Deleted in Colorectal-Cancer. Journal of Cell Biology 127: 2009-2020.
25. Keeling SL, Gad JM, Cooper HM, (1997) Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene 15: 691-700.
26. Okamura Y, Yamashita T, (2009) TACE-induced cleavage of Neogenin disinhibits the effect of RGMa on CNS axon/neurite outgrowth inhibition in rat primary cortical neuron. Neuroscience Research 65: S158-S158.
27. Matsunaga E, Nakamura H, Chedotal A, (2006) Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J Neurosci 26: 6082-6088.
28. Tadagavadi RK, Wang W, Ramesh G, (2010) Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 185: 3750-3758.
29. Mirakaj V, Thix CA, Laucher S, Mielke C, Morote-Garcia JC, et al. (2010) Netrin-1 dampens pulmonary inflammation during acute lung injury. Am J Respir Crit Care Med 181: 815-824.
30. Wu JY, Feng L, Park HT, Havlioglu N, Wen L, et al. (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410: 948-952.
31. Kanellis J, Garcia GE, Li P, Parra G, Wilson CB, et al. (2004) Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Am J Pathol 165: 341-352.
32. Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, et al. (2005) Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A 102: 14729-14734.
33. Wang W, Reeves WB, Ramesh G, (2008) Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol 294: F739-747.