Virus-specific CD8 + T-cells detected in PBMC from horses vaccinated against African horse sickness virus

Veterinary Immunology and Immunopathology

Volumn 146, Issue 1, 2012, Pages 81-86

  Pretorius, Alri ^a   Van Kleef, Mirinda ^a   Van Wyngaardt, Wouter ^a   Heath, Jeanette ^b  

^a ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

^b Onderstepoort Biological Products   (South Africa)

Author keywords

African horsesickness virus; CD4; CD8; Cellular immunity; Cytokines; ELISPOT

Indexed keywords

ANTIBODY; INTERLEUKIN 4; MESSENGER RNA; VIRUS VACCINE;

AFRICAN HORSE SICKNESS VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; HORSE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOASSAY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VACCINATION; VIRUS INFECTION;

AFRICAN HORSE SICKNESS VIRUS; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HORSES; INTERFERON-GAMMA; INTERLEUKIN-4; MALE; VACCINATION; VIRAL VACCINES;

AFRICAN HORSE SICKNESS VIRUS 4; AFRICAN HORSESICKNESS VIRUS; EQUIDAE;

EID: 84857801896     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2012.01.016     Document Type: Article

References (29)

1. Ainsworth D.M., Appleton J.A., Eicker S.W., Luce R., Flaminio M.J., Antczak D.F. The effect of strenuous exercise on mRNA concentrations of interleukin-12, interferon-gamma and interleukin-4 in equine pulmonary and peripheral blood mononuclear cells. Vet. Immunol. Immunopathol. 2003, 91:61-71.
2. Alexander R. A. Studies on the neurotropic virus of horsesickness III. The intracerebral protection test and its application to the study of immunity. Onderstepoort J. Vet. Res. 1935, 4:349-377.
3. Babiuk L.A., Pontarollo R., Babiuk S., Loehr B., Van Drunen Littel-Van Den Hurk S. Induction of immune responses by DNA vaccines in large animals. Vaccine 2003, 21:649-658.
4. Bentley L., Fehrsen J., Jordaan F., Huismans H., du Plessis D.H. Identification of antigenic regions on VP2 of African horsesickness virus serotype 3 by using phage-displayed epitope libraries. J. Gen. Virol. 2000, 81:993-1000.
5. Blackburn N.K., Swanepoel R. Observations on antibody levels associated with active and passive immunity to African horse sickness. Trop. Anim. Health Prod. 1988, 20:203-210.
6. Burrage T.G., Trevejo R., Stone-Marschat M., Laegreid W.W. Neutralizing epitopes of African horsesickness virus serotype 4 are located on VP2. Virology 1993, 196:799-803.
7. Carrasco L., Sánchez C., Gómez-Villamandos J.C., Laviada M.D., Bautista M.J., Martínez-Torrecuadrada J., Sánchez-Vizcaíno J.M., Sierra M.A. The role of pulmonary intravascular macrophages in the pathogenesis of African horse sickness. J. Comp. Pathol. 1999, 121:25-38.
8. Chiam R., Sharp E., Maan S., Rao S., Mertens P., Blacklaws B., Davis-Poynter N., Wood J., Castillo-Olivares J. Induction of antibody responses to African Hors Sickness Virus (AHSV) in ponies after vaccination with recombinant modified Vaccinia Ankara (MVA). PLOS ONE 2009, 4:e5997.
9. Clift S.J., Penrith M.L. Tissue and cell tropism of African horse sickness virus demonstrated by immunoperoxidase labeling in natural and experimental infection in horses in South Africa. Vet. Pathol. 2010, 47:690-697.
10. Coombs D.K., Patton T., Kohler A.K., Soboll G., Breathnach C., Townsend H.G.G., Lunn D.P. Cytokine responses to EHV-1 infection in immune and non-immune ponies. Vet. Immunol. Immunopathol. 2006, 111:109-116.
11. Erasmus B.J. A new approach to polyvalent immunization against African horsesickness. Equine Infectious Diseases IV 1978, 401-403. J.T. Bryans, H. Gerber (Eds.).
12. Erasmus B.J. The pathogenesis of African Horsesickness. Proc. 3rd Int. Conf. Equine Infectious Diseases, vol. 1072 1973, 1-11.
13. Figueiredo M.D., Vandenplas M.L., Hurley D.J., Moore J.N. Differential induction of MyD88- and TRIF-dependent pathways in equine monocytes by Toll-like receptor agonists. Vet. Immunol. Immunopathol. 2009, 127:125-134.
14. Guthrie A.J., Quan M., Lourens C.W., Audonnet J.C., Minke J.M., Yao J., He L., Nordgren R., Gardner I.A., Maclachlan N.J. Protective immunization of horses with a recombinant canarypox virus vectored vaccine co-expressing genes encoding the outer capsid proteins of African horse sickness virus. Vaccine 2009, 27:4434-4438.
15. + T-cell dependent activation of NK cells following vaccination. J. Immunol. 2010, 185:2808-2818.
16. Huismans H., Van der Walt N.T., Cloete M., Erasmus B.J. Isolation of a capsid protein of bluetongue virus that induces a protective immune response in sheep. Virology 1989, 157:172-179.
17. Huismans H., van Dijk A.A., Bauskin A.R. In vitro phosphorylation and purification of a nonstructural protein of bluetongue virus with affinity for single-stranded RNA. J. Virol. 1987, 61:3589-3595.
18. Koyama S., Ishii K.J., Coban C., Akira S. Innate immune response to viral infection. Cytokine 2008, 43:336-341.
19. Lecoq L., Vincent P., Lavoie-Lamoureux A., Lavoie J.P. Genomic and non-genomic effects of dexamethasone on equine peripheral blood neutrophils. Vet. Immunol. Immunopathol. 2009, 128:126-131.
20. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
21. Romito M., Du Plessis D.H., Viljoen G.J. Immune responses in a horse inoculated with the VP2 gene of African horsesickness virus. Onderstepoort J. Vet. Res. 1999, 66:139-144.
22. Saikh K.U., Lee J.S., Kissner T.L., Dyas B., Ulrich R.G. Toll-like receptor and cytokine expression patterns of CD56+ T-cells are similar to natural killer cells in response to infection with Venezuelan equine encephalitis virus replicons. J. Infect. Dis. 2003, 188:1562-1570.
23. Sánchez-Vizcaíno J.M. African horsesickness. OIE Manual of Standards for Diagnostic Tests and Vaccines 2000, p. 184. Fourth ed.
24. Scanlen M., Paweska J.T., Verschoor J.A., van Dijk A.A. The protective efficacy of a recombinant VP2-based African horsesickness subunit vaccine candidate is determined by adjuvant. Vaccine 2002, 20:1079-1088.
25. Schwartz-Cornil I., Mertens P.P.C., Contreras V., Hemati1 B., Pascale F., Bréard E., Mellor P.S., MacLachlan N.J., Zientara S. Bluetongue virus: virology, pathogenesis and immunity. Vet. Res. 2008, 39:46.
26. Stone-Marschat M.A., Moss S.R., Burrage T.G., Barber M.L., Roy P., Laegreid W.W. Immunization with VP2 is sufficient for protection against lethal challenge with African Horsesickness Virus Type 4. Virology 1996, 220:219-222.
27. Umeshappa C.S., Singh K.P., Pandey A.B., Singh R.P., Nanjundappa R.H. Cell-mediated immune response and cross-protective efficacy of binary ethylenimine-inactivated bluetongue virus serotype-1 vaccine in sheep. Vaccine 2010, 28:2522-2531.
28. Witonsky S.G., Ellison S., Yang J., Gogal R.M., Lawler H., Suzuki Y., Sriranganathan N., Andrews F., Ward D., Lindsay D.S. Horses experimentally infected with sarcocystis neurona develop altered immune responses in vitro. J. Parasitol. 2008, 94:1047-1054.
29. Xu W., Santini P.A., Matthews A.J., Chiu A., Plebani A., He B., Chen K., Cerutti A. Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B-cells through an innate TLR3 pathway involving BAFF. J. Immunol. 2008, 181:276-287.