Selenium and/or iodine deficiency alters hepatic xenobiotic metabolizing enzyme activities in rats

Journal of Trace Elements in Medicine and Biology

Volumn 26, Issue 1, 2012, Pages 36-41

  Erkekoglu, Pinar ^a   Giray, Belma Kocer ^a   Caglayan, Aydan ^a   Hincal, Filiz ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Combined iodine and selenium deficiency; CYP450; Iodine deficiency; Selenium deficiency; Thyroid hormones; Xenobiotic metabolizing enzymes

Indexed keywords

CYTOCHROME B5; CYTOCHROME P450; DRINKING WATER; ETHOXYRESORUFIN DEETHYLASE; GLUTATHIONE TRANSFERASE; PENTOXYRESORUFIN DEALKYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; SODIUM PERCHLORATE; THYROID HORMONE; THYROTROPIN; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME ASSAY; IODINE DEFICIENCY; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; RAT; SELENIUM DEFICIENCY; THYROID HORMONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; XENOBIOTIC METABOLISM;

ANIMALS; IODINE; LIVER; MALE; METABOLIC DETOXICATION, DRUG; RATS; RATS, WISTAR; SELENIUM; XENOBIOTICS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84857799408     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2011.12.002     Document Type: Article

References (49)

1. Köhrle J., Jakob F., Contempré B., Dumont J.E. Selenium, the thyroid, and the endocrine system. Endocr Rev 2005, 26:944-984.
2. Gentile F., Di Lauro R., Salvatore G. Biosynthesis and secretion of thyroid hormones. Endocrinology 1995, 517-542. Saunders, Philadelphia, PA. L.J. DeGroot (Ed.).
3. Delange F., de Benoist B., Pretell E., Dunn J.T. Iodine deficiency in the world: where do we stand at the turn of the century?. Thyroid 2001, 11:437-447.
4. Steinbrenner H., Sies H. Protection against reactive oxygen species by selenoproteins. Biochim Biophys Acta 2009, 1790:1478-1485.
5. Köhrle J., Gärtner R. Selenium and thyroid. Best Pract Res Clin Endocrinol Metab 2009, 23:815-827.
6. Vanderpas J.B., Contempré B., Duale N.L., Goossens W., Bebe N., Thorpe R., et al. Iodine and selenium deficiency associated with cretinism in northern Zaire. Am J Clin Nutr 1990, 52:1087-1093.
7. Danielson P.B. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab 2002, 3:561-597.
8. Akiyama T.E., Gonzalez F.J. Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta 2003, 1619:223-234.
9. Fishman J., Hellman L., Zumoff B., Gallagher T.F. Effect of thyroid on hydroxylation of estrogen in man. J Clin Endocrinol Metab 1965, 25:365-368.
10. Cheung N.W., Liddle C., Coverdale S., Lou J.C., Boyages S.C. Growth hormone treatment increases cytochrome P450-mediated antipyrine clearance in man. J Clin Endocrinol Metab 1995, 81:1999-2001.
11. Ram P.A., Waxman D.J. Pretranslational control by thyroid hormone of rat liver steroid 5α-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J Biol Chem 1990, 265:19223-19229.
12. Waxman D.J., Morrissey J.J., Naik S., Jauregui H.O. Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochem J 1990, 271:113-119.
13. Ip C., Lisk D.J. Modulation of phase I and phase II xenobiotic-metabolizing enzymes by selenium-enriched garlic in rats. Nutr Cancer 1997, 28:184-188.
14. Liddle C., Goodwin B.J., George J., Tapner M., Farrell G.C. Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 1998, 83:2411-2416.
15. Reiter R., Wendel A. Selenium and drug metabolism - I. Multiple modulations of mouse liver enzymes. Biochem Pharmacol 1983, 32:3063-3067.
16. Omura T., Sato R. The carbonmonoxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 1964, 239:2370-2378.
17. Phillips A.H., Langdon R.G. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization and kinetic studies. J Biol Chem 1962, 237:2652-2660.
18. Imai Y., Ito A., Sato R. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem 1966, 60:417-428.
19. Prough R.A., Burke M.D., Mayer R.T. Direct fluorometric methods for measuring mixed function oxidase activity. Methods Enzymol 1978, 52:372-377.
20. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases, the first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
21. Lowry O.H., Rosebrough N.J., Faar A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
22. Chow S.Y., Woodbury D.M. Kinetics of distribution of radioactive perchlorate in rat and guinea-pig thyroid glands. J Endocrinol 1970, 47:207-218.
23. van Wijk N., Rijntjes E., van de Heijning B.J. Perinatal and chronic hypothyroidism impair behavioural development in male and female rats. Exp Physiol 2008, 93:1199-1209.
24. Yamada T. Effects of perchlorate and other anions on thyroxine metabolism in the rat. Endocrinology 1967, 81:1285-1290.
25. Tran N., Valentín-Blasini L., Blount B.C., McCuistion C.G., Fenton M.S., Gin E., et al. Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells. Am J Physiol Endocrinol Metab 2008, 294:E802-E806.
26. Giray B., Riondel J., Richard M.J., Favier A., Hincal F. Oxidant/antioxidant status in relation to thyroid hormone metabolism in selenium- and/or iodine-deficient rats. J Trace Elem Exp Med 2004, 17:109-121.
27. Malik R., Hodgson H. The relationship between the thyroid gland and the liver. QJM 2002, 95:559-569.
28. Mehrotra K., Morgenstern R., Lundqvist G., Becedas L., Bengtsson Ahlberg M., Georgellis A. Effects of peroxisome proliferators and/or hypothyroidism on xenobiotic-metabolizing enzymes in rat testis. Chem Biol Interact 1997, 104:131-145.
29. Ram P.A., Waxman D.J. Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. J Biol Chem 1992, 267:3294-3301.
30. Skett P., Weir A. Sex- and substrate-dependent effects of the thyroid gland on drug metabolism in the rat. Biochem Pharmacol 1983, 32:3115-3117.
31. Coecke S., Vanhaecke T., Foriers A., Phillips I.R., Vercruysse A., Shephard E.A., et al. Hormonal regulation of glutathione S-transferase expression in co-cultured adult rat hepatocytes. J Endocrinol 2000, 166:363-371.
32. Parkinson A. Biotransformation of xenobiotics. Casarett and Doull's toxicology. The basic science of poisons 2001, 133-224. McGraw Comp, North America. C.D. Klaassen (Ed.).
33. Ha H.R., Chen J., Freiburghaus A.U., Follath F. Metabolism of theophylline by cDNA-expressed human cytochromes P-450. Br J Clin Pharmacol 1995, 39:321-326.
34. Hoch F.L., Depierre J.W., Ernster L. Thyroid control over biomembranes. Liver-microsomal cytochrome b5 in hypothyroidism. Eur J Biochem 1980, 109:301-306.
35. Hill K.E., Burk R.F. Effect of selenium deficiency and vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes. J Biol Chem 1982, 257:10668-10672.
36. Pascoe G.A., Sakai-Wong J., Soliven E., Correia M.A. Regulation of intestinal cytochrome P-450 and heme by dietary nutrients. Critical role of selenium. Biochem Pharmacol 1983, 32:3027-3035.
37. Wrighton S.A., Elswick B. Modulation of the induction of rat hepatic cytochromes P-450 by selenium deficiency. Biochem Pharmacol 1989, 38:3767-3771.
38. Beckett G.J., Nicol F., Proudfoot D., Dyson K., Loucaides G., Arthur J.R. The changes in hepatic enzyme expression caused by selenium deficiency and hypothyroidism in rats are produced by independent mechanisms. Biochem J 1990, 266:743-747.
39. Matsumoto K., Suzuki A., Washimi H., Hisamatsu A., Okajo A., Ui I., et al. Electron paramagnetic resonance decay constant and oxidative stresses in liver microsomes of the selenium-deficient rat. J Nutr Biochem 2006, 17:677-681.
40. Zimmerman H.J. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver 1999, Lippincott, Williams & Wilkins, Philadelphia.
41. Mark S.D., Qiao Y.L., Dawsey S.M., Wu Y.P., Katki H., Gunter E.W., et al. Prospective study of serum selenium levels and incident esophageal and gastric cancers. J Natl Cancer Inst 2000, 92:1753-1763.
42. Seitz H.K., Stickel F., Homann N. Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics. Int J Cancer 2004, 108:483-487.
43. Elmore C.L., Porter T.D. Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in vivo. J Biol Chem 2002, 277:48960-48964.
44. Yamazaki H., Nakano M., Imai Y., Ueng Y.F., Guengerich F.P., Shimada T. Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P450 3A4 and by human liver microsomes. Arch Biochem Biophys 1996, 325:174-182.
45. Yamazaki H., Nakajima M., Nakamura M., Asahi S., Shimada N., Gillam E.M., et al. Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Drug Metab Dispos 1999, 27:999-1004.
46. Yamazaki H., Nakamura M., Komatsu T., Ohyama K., Hatanaka N., Asahi S., et al. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expr Purif 2002, 24:329-337.
47. Gu J., Weng Y., Zhang Q.Y., Cui H.D., Behr M., Wu L., et al. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J Biol Chem 2003, 278:25895-25901.
48. Voice M.W., Zhang Y., Wolf C.R., Burchell B., Friedberg T. Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo. Arch Biochem Biophys 1999, 366:116-124.
49. Perera F.P., Mooney L.A., Stampfer M., Phillips D.H., Bell D.A., Rundle A., et al. Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study. Carcinogenesis 2002, 23:1641-1646.