Investigation of Microbubble Response to Long Pulses Used in Ultrasound-Enhanced Drug Delivery

Ultrasound in Medicine and Biology

Volumn 38, Issue 4, 2012, Pages 681-691

  Mannaris, Christophoros ^a   Averkiou, Michalakis A ^a  

^a UNIVERSITY OF CYPRUS   (Cyprus)

Author keywords

Acoustic streaming; Drug delivery; Microbubble destruction; Ultrasound contrast agents

Indexed keywords

ACOUSTIC PRESSURES; IN-VITRO; LONG PULSE; MICRO-BUBBLE; MICROBUBBLES; NON DESTRUCTIVE; SET-UPS; ULTRASONIC PULSE; ULTRASOUND CONTRAST AGENTS;

ACOUSTIC STREAMING; DRUG INTERACTIONS; ULTRASONICS;

DRUG DELIVERY;

ACCURACY; ARTICLE; CAPILLARY TUBE; CONCENTRATION (PARAMETERS); CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ECHOGRAPHY; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IMAGE PROCESSING; IMAGING SYSTEM; IN VITRO STUDY; MICROBUBBLE; OSCILLATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; RADIATION EXPOSURE; TUBE FLOW; WAVEFORM;

ACOUSTICS; CONTRAST MEDIA; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; MICROBUBBLES; PHOSPHOLIPIDS; SULFUR HEXAFLUORIDE; TRANSDUCERS; ULTRASONICS;

EID: 84857796760     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2011.12.018     Document Type: Article

References (69)

1. Appel R.E. Possibility of microcavitation from diagnostic ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 1986, 33:139-142.
2. Arvanitis C.D., Bazan-Peregrino M., Rifai B., Seymour L.W., Coussios C.C. Cavitation-enhanced extravasation for drug delivery. Ultrasound Med Biol 2011, 37:1838-1852.
3. Averkiou M., Powers J., Skyba D., Bruce M., Jensen S. Ultrasound contrast imaging research. Ultrasound Q 2003, 19:27-37.
4. Averkiou MA, Bruce M, Jensen S, Rafter P, Brock-Fisher T, Powers J. Pulsing schemes for the detection of nonlinear echoes from contrast microbubbles. 9th European Symposium on Ultrasound Contrast Imaging, Rotterdam, The Netherlands, 2004.
5. Baker K.G., Robertson V.J., Duck F.A. A review of therapeutic ultrasound: Biophysical effects. Phys Ther 2001, 81:1351-1358.
6. Bekeredjian R., Chen S., Grayburn P.A., Shohet R.V. Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol 2005, 31:687-691.
7. Bohmer M.R., Chlon C.H.T., Raju B.I., Chin C.T., Shevchenko T., Klibanov A.L. Focused ultrasound and microbubbles for enhanced extravasation. J Control Release 2010, 148:18-24.
8. Bohmer M.R., Klibanov A.L., Tiemann K., Hall C.S., Gruell H., Steinbach O.C. Ultrasound triggered image-guided drug delivery. Eur J Radiol 2009, 70:242-253.
9. Bradley C.E. Acoustic streaming field structure: The influence of the radiator. J Acoust Soc Am 1996, 100:1399-1408.
10. Brock-Fisher G, Poland M, Rafter P. Means for increasing sensitivity in non-linear ultrasound imaging systems (1996) Patent: US 5577505.
11. Bruce M., Averkiou M., Tiemann K., Lohmaier S., Powers J., Beach K. Vascular flow and perfusion imaging with ultrasound contrast agents. Ultrasound Med Biol 2004, 30:735-743.
12. Church C.C. A theoretical study of cavitation generated by an extracorporeal shock wave lithotripter. J Acoust Soc Am 1989, 86:215-227.
13. Curley S.A., Izzo F., Delrio P., Ellis L.M., Granchi J., Vallone P., Fiore F., Pignata S., Daniele B., Cremona F. Radio-frequency ablation of unresectable primary and metastatic hepatic malignancies: Results in 123 patients. Ann Surg 1999, 230:1-8.
14. Dayton P., Klibanov A., Brandenburger G., Ferrara K. Acoustic radiation force in vivo: A mechanism to assist targeting of microbubbles. Ultrasound Med Biol 1999, 25:1195-1201.
15. Dijkmans P.A., Juffermans L.J., Musters R.J., van Wamel A., ten Cate F.J., van Gilst W., Visser C.A., de Jong N., Kamp O. Microbubbles and ultrasound: From diagnosis to therapy. Eur J Echocardiogr 2004, 5:245-256.
16. Doinikov A.A., Bouakaz A. Acoustic microstreaming around a gas bubble. J Acoust Soc Am 2010, 127:703-709.
17. Duck F. Acoustic streaming and radiation pressure in diagnostic applications. Safety of diagnostic ultrasound 1998, 87-98. Parthenon, Carnforth, UK. S. Barnett, G. Kossoff (Eds.).
18. Ellegala D.B., Leong-Poi H., Carpenter J.E., Klibanov A.L., Kaul S., Shaffrey M.E., Sklenar J., Lindner J.R. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to α(v)β3. Circulation 2003, 108:336-341.
19. Escoffre J.M., Piron J., Novell A., Bouakaz A. Doxorubicin delivery into tumor cells with ultrasound and microbubbles. Mol Pharm 2011, 8:799-806.
20. Ghanem A., Steingen C., Brenig F., Funcke F., Bai Z.Y., Hall C., Chin C.T., Nickenig G., Bloch W., Tiemann K. Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction. J Mol Cell Cardiol 2009, 47:411-418.
21. Goertz D.E., de Jong N., van der Steen A.F.W. Attenuation and size distribution measurements of Definity™ and manipulated Definity™ populations. Ultrasound Med Biol 2007, 33:1376-1388.
22. Gramiak R., Shah P.M. Echocardiography of the aortic root. Invest Radiol 1968, 3:356-366.
23. Hernot S., Klibanov A.L. Microbubbles in ultrasound-triggered drug and gene delivery. Adv Drug Deliv Rev 2008, 60:1153-1166.
24. Holland C.K., Apfel R.E. Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment. J Acoust Soc Am 1990, 88:2059-2069.
25. Hwang J.H., Brayman A.A., Reidy M.A., Matula T.J., Kimmey M.B., Crum L.A. Vascular effects induced by combined 1-MHz ultrasound and microbubble contrast agent treatments in vivo. Ultrasound Med Biol 2005, 31:553-564.
26. Hwang J.H., Tu J., Brayman A.A., Matula T.J., Crum L.A. Correlation between inertial cavitation dose and endothelial cell damage in vivo. Ultrasound Med Biol 2006, 32:1611-1619.
27. Iwanaga K., Tominaga K., Yamamoto K., Habu M., Maeda H., Akifusa S., Tsujisawa T., Okinaga T., Fukuda J., Nishihara T. Local delivery system of cytotoxic agents to tumors by focused sonoporation. Cancer Gene Ther 2007, 14:354-363.
28. Karshafian R., Bevan P.D., Williams R., Samac S., Burns P.N. Sonoporation by ultrasound-activated microbubble contrast agents: Effect of acoustic exposure parameters on cell membrane permeability and cell viability. Ultrasound Med Biol 2009, 35:847-860.
29. Kennedy J.E., Wu F., ter Haar G.R., Gleeson F.V., Phillips R.R., Middleton M.R., Cranston D. High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics 2004, 42:931-935.
30. Kinoshita M., Hynynen K. Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound. Pharm Res 2005, 22:716-720.
31. Klibanov A.L. Microbubble contrast agents: Targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest Radiol 2006, 41:354-362.
32. Kooiman K., Emmer M., Foppen-Harteveld M., van Wamel A., de Jong N. Increasing the endothelial layer permeability through ultrasound-activated microbubbles. IEEE Trans Bio Med Eng 2010, 57:29-32.
33. Lampaskis M., Averkiou M. Investigation of the relationship of nonlinear backscattered ultrasound intensity with microbubble concentration at low MI. Ultrasound Med Biol 2010, 36:306-312.
34. Leen E., Goldberg J.A., Angerson W.J., McArdle C.S. Potential role of Doppler perfusion index in selection of patients with colorectal cancer for adjuvant chemotherapy. Lancet 2000, 355:34-37.
35. Li P., Armstrong W.F., Miller D.L. Impact of myocardial contrast echocardiography on vascular permeability: Comparison of three different contrast agents. Ultrasound Med Biol 2004, 30:83-91.
36. Li P., Cao L.Q., Dou C.Y., Armstrong W.F., Miller D. Impact of myocardial contrast echocardiography on vascular permeability: An in vivo dose response study of delivery mode, pressure amplitude and contrast dose. Ultrasound Med Biol 2003, 29:1341-1349.
37. Lin C.Y., Li J.R., Tseng H.C., Wu M.F., Lin W.L. Enhancement of focused ultrasound with microbubbles on the treatments of anticancer nanodrug in mouse tumors. Nanomedicine NBM 2011, (in press).
38. Lindner J.R. Microbubbles in medical imaging: Current applications and future directions. Nat Rev Drug Discov 2004, 3:527-532.
39. Lum A.F.H., Borden M.A., Dayton P.A., Kruse D.E., Simon S.I., Ferrara K.W. Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles. J Control Release 2006, 111:128-134.
40. Marmottant P., Hilgenfeldt S. Controlled vesicle deformation and lysis by single oscillating bubbles. Nature 2003, 423:153-156.
41. Mehier-Humbert S., Yan F., Frinking P., Schneider M., Guy R.H., Bettinger T. Ultrasound-mediated gene delivery: Influence of contrast agent on transfection. Bioconjug Chem 2007, 18:652-662.
42. Miller D.L., Song J. Tumor growth reduction and DNA transfer by cavitation-enhanced high-intensity focused ultrasound in vivo. Ultrasound Med Biol 2003, 29:887-893.
43. Molina C.A., Ribo M., Rubiera M., Montaner J., Santamarina E., Delgado-Mederos R., Arenillas J.F., Huertas R., Purroy F., Delgado P., Alvarez-Sabin J. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke 2006, 37:425-429.
44. Nyborg W. Acoustic streaming. Physical acoustics 1965, 265-331. Academic Press, New York. W. Mason (Ed.).
45. Quaia E., Palumbo A., Rossi S., Degobbis F., Cernic S., Tona G., Cova M. Comparison of visual and quantitative analysis for characterization of insonated liver tumors after microbubble contrast injection. AJR Am J Roentgenol 2006, 186:1560-1570.
46. Rahim A., Taylor S.L., Bush N.L., ter Haar G.R., Bamber J.C., Porter C.D. Physical parameters affecting ultrasound/microbubble-mediated gene delivery efficiency in vitro. Ultrasound Med Biol 2006, 32:1269-1279.
47. Rahim A.A., Taylor S.L., Bush N.L., ter Haar G.R., Bamber J.C., Porter C.D. Spatial and acoustic pressure dependence of microbubble-mediated gene delivery targeted using focused ultrasound. J Gene Med 2006, 8:1347-1357.
48. Seip R., Chin C.T., Hall C.S., Raju B.I., Ghanem A., Tiemann K. Targeted ultrasound-mediated delivery of nanoparticles: On the development of a new HIFU-based therapy and imaging device. IEEE Trans Biomed Eng 2010, 57:61-70.
49. Shen Z.P., Brayman A.A., Chen L., Miao C.H. Ultrasound with microbubbles enhances gene expression of plasmid DNA in the liver via intraportal delivery. Gene Ther 2008, 15:1147-1155.
50. Shi W.T., Forsberg F., Tornes A., Ostensen J., Goldberg B.B. Destruction of contrast microbubbles and the association with inertial cavitation. Ultrasound Med Biol 2000, 26:1009-1019.
51. Shi X.G., Martin R.W., Vaezy S., Crum L.A. Quantitative investigation of acoustic streaming in blood. J Acoust Soc Am 2002, 111:1110-1121.
52. Shi WT, Böhmer M, Van Wamel A, Celebi M, Klibanov AL, Chin CT, Chlon C, Hall CS. Ultrasound therapy with drug loaded microcapsules. Proceedings - IEEE Ultrasonics Symposium, 2007, art. no. 4409771, pp. 773-776.
53. Shortencarier M.J., Dayton P.A., Bloch S.H., Schumann P.A., Matsunaga T.O., Ferrara K.W. A method for radiation-force localized drug delivery using gas-filled lipospheres. IEEE Trans Ultrason Ferroelectr Freq Control 2004, 51:822-831.
54. Simpson D.H., Chin C.T., Burns P.N. Pulse inversion Doppler: A new method for detecting nonlinear echoes from microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 1999, 46:372-382.
55. Skyba D.M., Price R.J., Linka A.Z., Skalak T.C., Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998, 98:290-293.
56. Starritt H.C., Duck F.A., Humphrey V.F. An experimental investigation of streaming in pulsed diagnostic ultrasound beams. Ultrasound Med Biol 1989, 15:363-373.
57. Tjotta S. Some nonlinear effects in sound fields. J Sound Vibration 1967, 6:255-267.
58. van Wamel A., Kooiman K., Harteveld M., Emmer M., ten Cate F.J., Versluis M., de Jong N. Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation. J Control Release 2006, 112:149-155.
59. Vandenbroucke R.E., Lentacker I., Demeester J., De Smedt S.C., Sanders N.N. Ultrasound assisted siRNA delivery using PEG-siPlex loaded microbubbles. J Control Rel 2008, 126:265-273.
60. Wei K., Jayaweera A.R., Firoozan S., Linka A., Skyba D.M., Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998, 97:473-483.
61. Weller G.E., Lu E., Csikari M.M., Klibanov A.L., Fischer D., Wagner W.R., Villanueva F.S. Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intercellular adhesion molecule-1. Circulation 2003, 108:218-224.
62. Weller G.E.R., Wong M.K.K., Modzelewski R.A., Lu E.X., Klibanov A.L., Wagner W.R., Villanueva F.S. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 2005, 65:533-539.
63. Wible J.H., Galen K.P., Wojdyla J.K., Hughes M.S., Klibanov A.L., Brandenburger G.H. Microbubbles induce renal hemorrhage when exposed to diagnostic ultrasound in anesthetized rats. Ultrasound Med Biol 2002, 28:1535-1546.
64. Wilson S.R., Burns P.N. Liver mass evaluation with ultrasound: The impact of microbubble contrast agents and pulse inversion imaging. Semin Liver Dis 2001, 21:147-159.
65. Wood R.W., Loomis A.L. The physical and biological effects of high frequency sound waves of great intensity. Philosophical Magazine 1927, 4:417-436.
66. Yu T., Wang Z., Mason T.J. A review of research into the uses of low level ultrasound in cancer therapy. Ultrason Sonochem 2004, 11:95-103.
67. Yudina A., Lepetit-Coiffe M., Moonen C.T. Evaluation of the temporal window for drug delivery following ultrasound-mediated membrane permeability enhancement. Mol Imaging Biol 2011, 13:239-249.
68. Zauhar G., Starritt H.C., Duck F.A. Studies of acoustic streaming in biological fluids with an ultrasound Doppler technique. Br J Radiol 1998, 71:297-302.
69. Zenitani T., Suzuki R., Maruyama K., Furuhata H. Accelerating effects of ultrasonic thrombolysis with bubble liposomes. J Med Ultrason 2008, 35:5-10.