Development of a novel ultra cryo-milling technique for a poorly water-soluble drug using dry ice beads and liquid nitrogen

International Journal of Pharmaceutics

Volumn 426, Issue 1-2, 2012, Pages 162-169

  Sugimoto, Shohei ^a   Niwa, Toshiyuki ^a   Nakanishi, Yasuo ^b   Danjo, Kazumi ^a  

^a MEIJO UNIVERSITY   (Japan)

^b Development Center   (Japan)

Author keywords

Cryo milling; Dry ice beads; Jet milling; Liquid nitrogen; Submicron; Zirconia beads

Indexed keywords

CARBON DIOXIDE; LIQUID NITROGEN; PHENYTOIN; POVIDONE; ZIRCONIUM OXIDE;

ARTICLE; DRUG SOLUBILITY; GLASS TRANSITION TEMPERATURE; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SURFACE PROPERTY; ULTRA CRYO MILLING MICRONIZATION TECHNIQUE; VELOCITY;

ADHESIVENESS; CHEMISTRY, PHARMACEUTICAL; COLD TEMPERATURE; CRYSTALLIZATION; DRUG COMPOUNDING; DRY ICE; MICROSCOPY, ELECTRON, SCANNING; NANOTECHNOLOGY; NITROGEN; PARTICLE SIZE; PHASE TRANSITION; PHENYTOIN; POVIDONE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE; ZIRCONIUM;

EID: 84857794399     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.01.007     Document Type: Article

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