Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts

Molecular Therapy

Volumn 20, Issue 3, 2012, Pages 565-571

  Karakikes, Ioannis ^a   Hadri, Lahouaria ^a   Rapti, Kleopatra ^a   Ladage, Dennis ^a   Ishikawa, Kiyotake ^a   Tilemann, Lisa ^a   Yi, Geng Hua ^b   Morel, Charlotte ^a   Gwathmey, Judith K ^c   Zsebo, Krisztina ^d   Weber, Thomas ^a   Kawase, Yoshiaki ^a   Hajjar, Roger J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

^c Gwathmey Inc   (United States)

^d Celladon Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE THERAPY AGENT; GLYCERYL TRINITRATE; MESSENGER RNA; NICARDIPINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY SURFACE; CONTROLLED STUDY; GENE DOSAGE; GENE TRANSFER; HEART; HEART LEFT VENTRICLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART RATE; HEART RIGHT VENTRICLE; IMMUNOBLOTTING; IN VIVO STUDY; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; SWINE; SYSTOLIC BLOOD PRESSURE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS GENOME;

ANIMALIA; SUS;

EID: 84857785617     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.268     Document Type: Article

References (33)

1. Bers, DM (2000). Calcium fluxes involved in control of cardiac myocyte contraction. Circ Res 87: 275-281. (Pubitemid 30655967)
2. de la Bastie, D, Levitsky, D, Rappaport, L, Mercadier, JJ, Marotte, F, Wisnewsky, C et al. (1990). Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ Res 66: 554-564. (Pubitemid 20041186)
3. Mercadier, JJ, LompR̈ AM, Duc, P, Boheler, KR, Fraysse, JB, Wisnewsky, C et al. (1990). Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest 85: 305-309. (Pubitemid 20030324)
4. del Monte, F and Hajjar, RJ (2003). Efficient viral gene transfer to rodent hearts in vivo. Methods Mol Biol 219: 179-193.
5. del Monte, F and Hajjar, RJ (2003). Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol (Lond) 546(Pt 1): 49-61.
6. Kawase, Y and Hajjar, RJ (2008). The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nat Clin Pract Cardiovasc Med 5: 554-565.
7. Kawase, Y, Ly, HQ, Prunier, F, Lebeche, D, Shi, Y, Jin, H et al. (2008). Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol 51: 1112-1119. (Pubitemid 351374774)
8. Miyamoto, MI, del Monte, F, Schmidt, U, DiSalvo, TS, Kang, ZB, Matsui, T et al. (2000). Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA 97: 793-798. (Pubitemid 30070389)
9. Giordano, FJ, He, H, McDonough, P, Meyer, M, Sayen, MR and Dillmann, WH (1997). Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients. Circulation 96: 400-403. (Pubitemid 27329410)
10. Hajjar, RJ, Zsebo, K, Deckelbaum, L, Thompson, C, Rudy, J, Yaroshinsky, A et al. (2008). Design of a phase ? trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure. J Card Fail 14: 355-367. (Pubitemid 351756538)
11. Jaski, BE, Jessup, ML, Mancini, DM, Cappola, TP, Pauly, DF, Greenberg, B et al. (2009). Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-in-human phase ? clinical trial. J Card Fail 15: 171-181.
12. Jessup, M, Greenberg, B, Mancini, D, Cappola, T, Pauly, DF, Jaski, B et al. (2011). Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 124: 304-313.
13. Roth, DM, Lai, NC, Gao, MH, Fine, S, McKirnan, MD, Roth, DA et al. (2004). Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. Hum Gene Ther 15: 989-994. (Pubitemid 39372575)
14. Ikeda, Y, Gu, Y, Iwanaga, Y, Hoshijima, M, Oh, SS, Giordano, FJ et al. (2002). Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation 105: 502-508. (Pubitemid 34141709)
15. Ding, Z, Fach, C, Sasse, A, G̈ecke, A and Schrader, J (2004). A minimally invasive approach for efficient gene delivery to rodent hearts. Gene Ther 11: 260-265. (Pubitemid 38220077)
16. Wright, MJ, Wightman, LM, Latchman, DS and Marber, MS (2001). In vivo myocardial gene transfer: optimization and evaluation of intracoronary gene delivery in vivo. Gene Ther 8: 1833-1839. (Pubitemid 34141489)
17. Donahue, JK, Kikkawa, K, Thomas, AD, Marban, E and Lawrence, JH (1998). Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin. Gene Ther 5: 630-634. (Pubitemid 28256813)
18. Logeart, D, Hatem, SN, Heimburger, M, Le Roux, A, Michel, JB and Mercadier, JJ (2001). How to optimize in vivo gene transfer to cardiac myocytes: mechanical or pharmacological procedureS̈ Hum Gene Ther 12: 1601-1610. (Pubitemid 32911731)
19. Logeart, D, Hatem, SN, R̈ker-Martin, C, Chossat, N, N̈o, N, Haddada, H et al. (2000). Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Hum Gene Ther 11: 1015-1022. (Pubitemid 30250118)
20. Wang, Y, Boros, P, Liu, J, Qin, L, Bai, Y, Bielinska, AU et al. (2000). DNA/dendrimer complexes mediate gene transfer into murine cardiac transplants ex vivo. Mol Ther 2: 602-608.
21. Elkayam, U, Janmohamed, M, Habib, M and Hatamizadeh, P (2008). Vasodilators in the management of acute heart failure. Crit Care Med 36(suppl. 1): S95-105.
22. Dinerman, JL, Lawson, DL and Mehta, JL (1991). Interactions between nitroglycerin and endothelium in vascular smooth muscle relaxation. Am J Physiol 260(3 Pt 2): H698-H701.
23. Gill, RM, Braz, JC, Jin, N, Etgen, GJ and Shen, W (2007). Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling. Am J Physiol Heart Circ Physiol 292: H2782-H2790. (Pubitemid 47084527)
24. Hajjar, RJ, Schmidt, U, Matsui, T, Guerrero, JL, Lee, KH, Gwathmey, JK et al. (1998). Modulation of ventricular function through gene transfer in vivo. Proc Natl Acad Sci USA 95: 5251-5256. (Pubitemid 28208584)
25. Nagata, K, Marb́, E, Lawrence, JH and Donahue, JK (2001). Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. J Mol Cell Cardiol 33: 575-580. (Pubitemid 32539012)
26. Donahue, JK, Kikkawa, K, Johns, DC, Marban, E and Lawrence, JH (1997). Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci USA 94: 4664-4668. (Pubitemid 27194300)
27. Sasano, T, Kikuchi, K, McDonald, AD, Lai, S and Donahue, JK (2007). Targeted highefficiency, homogeneous myocardial gene transfer. J Mol Cell Cardiol 42: 954-961. (Pubitemid 46678029)
28. Gwathmey, JK, Yerevanian, AI and Hajjar, RJ (2011). Cardiac gene therapy with SERCA2a: from bench to bedside. J Mol Cell Cardiol 50: 803-812.
29. Waxman, S, Moreno, R, Rowe, KA and Verrier, RL (1999). Persistent primary coronary dilation induced by transatrial delivery of nitroglycerin into the pericardial space: a novel approach for local cardiac drug delivery. J Am Coll Cardiol 33: 2073-2077.
30. Roth, DM, Lai, NC, Gao, MH, Drumm, JD, Jimenez, J, Feramisco, JR et al. (2004). Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice. Am J Physiol Heart Circ Physiol 287: H172-H177. (Pubitemid 38802350)
31. Emani, SM, Shah, AS, Bowman, MK, Emani, S, Wilson, K, Glower, DD et al. (2003). Catheter-based intracoronary myocardial adenoviral gene delivery: importance of intraluminal seal and infusion flow rate. Mol Ther 8: 306-313. (Pubitemid 37062840)
32. Champion, HC, Georgakopoulos, D, Haldar, S, Wang, L, Wang, Y and Kass, DA (2003). Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation 108: 2790-2797. (Pubitemid 37498982)
33. O'Connell, KM, Whitesell, JD and Tamkun, MM (2008). Localization and mobility of the delayed-rectifer K+ channel Kv2.1 in adult cardiomyocytes. Am J Physiol Heart Circ Physiol 294: H229-H237.