Catheter-based intracoronary myocardial adenoviral gene delivery: Importance of intraluminal seal and infusion flow rate

Molecular Therapy

Volumn 8, Issue 2, 2003, Pages 306-313

  Emani, Sitaram M ^a   Shah, Ashish S ^a   Bowman, Michael K ^a   Emani, Sitaramesh ^a   Wilson, Katrina ^a   Glower, Donald D ^a   Koch, Walter J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Gene therapy; Heart failure; Myocardium; Receptor; adrenergic

Indexed keywords

ADENOVIRUS VECTOR; BETA 2 ADRENERGIC RECEPTOR; BETA GALACTOSIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BALLOON CATHETER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY BLOOD VESSEL; FLOW RATE; FLUOROSCOPY; HEART CATHETERIZATION; HEART MUSCLE; HEART MUSCLE INJURY; HISTOPATHOLOGY; IN VIVO STUDY; NONHUMAN; REPRODUCIBILITY; RIGHT CORONARY ARTERY; SWINE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALIA; ORYCTOLAGUS CUNICULUS; PHOCIDAE; SUS SCROFA;

EID: 0042856409     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1525-0016(03)00149-7     Document Type: Article

References (25)

1. White, D. C., and Koch, W. J. (2001). Myocardial gene transfer. Curr. Cardiol. Rep. 3: 37-42.
2. French, B. A., Mazur, W., Geske, R. S., and Bolli, R. (1994). Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation 90: 2414-2424.
3. Patel, S. R., et al. (1999). Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121. Hum. Gene Ther. 10: 1331-1348.
4. Hajjar, R. J., et al. (1998). Modulation of ventricular function through gene transfer in vivo. Proc. Natl. Acad. Sci. USA 95: 5251-5256.
5. 2-adrenergic receptor gene delivery. J. Clin. Invest. 104: 21-29.
6. Miyamoto, M. I., et al. (2000). Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA 97: 793-798.
7. Tevaearai, H. T., Eckhart, A. D., Shotwell, K. F., Wilson, K., and Koch, W. J. (2001). Ventricular dysfunction following cardioplegic arrest is improved after myocardial gene transfer of a β-adrenergic receptor kinase inhibitor. Circulation 104: 2069-2074.
8. Davidson, M. J., et al. (2001). Cardiac gene delivery with cardiopulmonary bypass. Circulation 104: 131-133.
9. 2-adrenergic receptor in the heart: prospects for molecular ventricular assistance. Circulation 101: 408-414.
10. Shah, A. S., et al. (2001). In vivo ventricular gene delivery of a β-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103: 1311-1316.
11. Emani, S. M., Shah, A. S., White, D. C., Glower, D. D., and Koch, W. J. (2001). Right ventricular gene therapy with a β-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding. Ann. Thoracic Surg. 72: 1657-1661.
12. Barr, E., et al. (1994). Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus. Gene Ther. 1: 51-58.
13. Donahue, J. K., Kikkawa, K., Johns, D. C., Marban, E., and Lawrence, J. H. (1997). Ultrarapid, highly efficient viral gene transfer to the heart. Proc. Natl. Acad. Sci. USA 94: 4664-4668.
14. Donahue, J. K., Kikkawa, K., Thomas, A. D., Marban, E., and Lawrence, J. H. (1998). Acceleration of widespread adenoviral gene transfer to intact rabbit hearts by coronary perfusion with low calcium and serotonin. Gene Ther. 5: 630-634.
15. Logeart, D., et al. (2000). Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Hum. Gene Ther. 11: 1015-1022.
16. 2-adrenergic receptor. Science 264: 582-586.
17. 2-adrenergic receptors differentially affects cardiac hypertrophy and function in Gαq overexpressing mice. Proc. Natl. Acad. Sci. USA 96: 6400-6405.
18. 2-adrenergic receptors potentiates the functional recovery of unloaded failing hearts. Circulation 106: 124-129.
19. Jones, J. M., Wilson, K. H., Koch, W. J., and Milano, C. A. (2002). Adenoviral gene transfer to the heart during cardiopulmonary bypass: effects of myocardial protection technique on transgene expression. Eur. J. Cardiothoracic Surg. 21: 847-852.
20. Muhlhauser, J., et al. (1996). Safety and efficacy of in vivo gene transfer into porcine heart with replication-deficient, recombinant adenovirus vectors. Gene Ther. 3: 145-153.
21. Giordano, F. J., et al. (1996). Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat. Med. 2: 534-539.
22. Lai, N. C., et al. (2000). Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation 102: 2396-2401.
23. Rao, J., Mascarenhas, D. A., and Schiavone, J. (2002). Nondominant right coronary artery occlusion and ventricular tachyarrhythmias. Catheter Cardiovasc. Interv. 56: 53-57.
24. White, D. C., Hata, J. A., Shah, A. S., Glower, D. D., Lefkowitz, R. J., and Koch, W. J. (2000). Preservation of myocardial β-adrenergic receptor delays the development of heart failure following myocardial infarction. Proc. Natl. Acad. Sci. USA 97: 5428-5433.
25. Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., and Sasayama, S. (1999). Contribution of endothelin-1 to myocardial injury in a murine model of myocarditis: acute effects of bosentan, an endothelin receptor antagonist. Circulation 100: 1823-1829.