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Volumn 129, Issue 3, 2012, Pages 296-300

The protein C pathway and sepsis

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; APOLIPOPROTEIN E RECEPTOR 2; BETA1 INTEGRIN; BETA3 INTEGRIN; CD11B ANTIGEN; DROTRECOGIN; ENDOTHELIAL PROTEIN C RECEPTOR; ENZYME PRECURSOR; PROTEIN C; PROTEINASE ACTIVATED RECEPTOR 1; RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

EID: 84857784949     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.11.013     Document Type: Review
Times cited : (25)

References (58)
  • 1
    • 0017111698 scopus 로고
    • A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase
    • C.T. Esmon, J. Stenflo, and J.W. Suttie A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase J Biol Chem 251 1976 3052 3056
    • (1976) J Biol Chem , vol.251 , pp. 3052-3056
    • Esmon, C.T.1    Stenflo, J.2    Suttie, J.W.3
  • 3
    • 0141819138 scopus 로고    scopus 로고
    • The protein C pathway
    • C.T. Esmon The protein C pathway Chest 124 Suppl. 3 2003 26S 32S (Pubitemid 37128433)
    • (2003) Chest , vol.124 , Issue.3 SUPPL.
    • Esmon, C.T.1
  • 4
    • 0021171729 scopus 로고
    • A model for thrombin protection against endotoxin
    • F.B. Taylor Jr., A. Chang, L.B. Hinshaw, C.T. Esmon, L.T. Archer, and B.K. Beller A model for thrombin protection against endotoxin Thromb Res 36 1984 177 185 (Pubitemid 14020862)
    • (1984) Thrombosis Research , vol.36 , Issue.2 , pp. 177-185
    • Taylor Jr., F.B.1    Chang, A.2    Hinshaw, L.B.3
  • 5
    • 0023122016 scopus 로고
    • Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
    • F.B. Taylor Jr., A. Chang, C.T. Esmon, A. D'Angelo, S. Vigano-D'Angelo, and K.E. Blick Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon J Clin Invest 79 1987 918 925 (Pubitemid 17050920)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.3 , pp. 918-925
    • Taylor Jr., F.B.1    Chang, A.2    Esmon, C.T.3
  • 6
    • 0021099422 scopus 로고
    • Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C
    • N.L. Esmon, L.E. DeBault, and C.T. Esmon Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C J Biol Chem 258 1983 5548 5553
    • (1983) J Biol Chem , vol.258 , pp. 5548-5553
    • Esmon, N.L.1    Debault, L.E.2    Esmon, C.T.3
  • 7
    • 2942744467 scopus 로고    scopus 로고
    • Severe protein C deficiency predicts early death in severe sepsis
    • W.L. Macias, and D.R. Nelson Severe protein C deficiency predicts early death in severe sepsis Crit Care Med 32 Suppl. 5 2004 S223 S228
    • (2004) Crit Care Med , vol.32 , Issue.SUPPL. 5
    • MacIas, W.L.1    Nelson, D.R.2
  • 8
    • 0035826096 scopus 로고    scopus 로고
    • Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis
    • G.R. Bernard, J.L. Vincent, P.F. Laterre, S.P. LaRosa, PC JF, and A. Lopez-Rodriguez Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 2001 699 709
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3    Larosa, S.P.4    Jf, P.5    Lopez-Rodriguez, A.6
  • 9
    • 77955980902 scopus 로고    scopus 로고
    • PROWESS-SHOCK trial: A protocol overview and perspectives
    • E. Silva, L.F. Poli de Figueiredo, and F. Colombari PROWESS-SHOCK trial: a protocol overview and perspectives Shock 34 Suppl. 1 2010 48 53
    • (2010) Shock , vol.34 , Issue.SUPPL. 1 , pp. 48-53
    • Silva, E.1    Poli De Figueiredo, L.F.2    Colombari, F.3
  • 10
    • 34147119744 scopus 로고    scopus 로고
    • The cytoprotective protein C pathway
    • DOI 10.1182/blood-2006-09-003004
    • L.O. Mosnier, B.V. Zlokovic, and J.H. Griffin The cytoprotective protein C pathway Blood 109 2007 3161 3172 (Pubitemid 46572500)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3161-3172
    • Mosnier, L.O.1    Zlokovic, B.V.2    Griffin, J.H.3
  • 11
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-γ, or phorbol ester
    • S.T. Grey, A. Tsuchida, H. Hau, C.L. Orthner, H.H. Salem, and W.W. Hancock Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester J Immunol 153 1994 3664 3672 (Pubitemid 24313871)
    • (1994) Journal of Immunology , vol.153 , Issue.8 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 12
    • 49649103818 scopus 로고    scopus 로고
    • Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes
    • Canadian Critical Care Translational Biology Group
    • L.J. Toltl, S. Beaudin, P.C. Liaw Canadian Critical Care Translational Biology Group Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes J Immunol 181 2008 2165 2173
    • (2008) J Immunol , vol.181 , pp. 2165-2173
    • Toltl, L.J.1    Beaudin, S.2    Liaw, P.C.3
  • 13
    • 40749112792 scopus 로고    scopus 로고
    • Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
    • C. Pereira, D.J. Schaer, E.B. Bachli, M.O. Kurrer, and G. Schoedon Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10 Arterioscler Thromb Vasc Biol 28 2008 504 510
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 504-510
    • Pereira, C.1    Schaer, D.J.2    Bachli, E.B.3    Kurrer, M.O.4    Schoedon, G.5
  • 14
    • 0035815747 scopus 로고    scopus 로고
    • Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis
    • DOI 10.1074/jbc.C100017200
    • D.E. Joyce, L. Gelbert, A. Ciaccia, B. DeHoff, and B.W. Grinnell Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis J Biol Chem 276 2001 11199 11203 (Pubitemid 38089304)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.14 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    DeHoff, B.4    Grinnell, B.W.5
  • 15
    • 36348978719 scopus 로고    scopus 로고
    • Activated protein C decreases tumor necrosis factor-related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation
    • DOI 10.1161/ATVBAHA.107.153734
    • L.A. O'Brien, M.A. Richardson, S.F. Mehrbod, D.T. Berg, B. Gerlitz, and A. Gupta Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR-independent mechanism involving Egr-1/Erk-1/2 activation Arterioscler Thromb Vasc Biol 27 2007 2634 2641 (Pubitemid 350158916)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.12 , pp. 2634-2641
    • O'Brien, L.A.1    Richardson, M.A.2    Mehrbod, S.F.3    Berg, D.T.4    Gerlitz, B.5    Gupta, A.6    Grinnell, B.W.7
  • 16
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signaling lipid
    • S. Spiegel, and S. Milstien Sphingosine-1-phosphate: an enigmatic signaling lipid Nat Rev Mol Cell Biol 4 2003 397 407
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 18
    • 77952296543 scopus 로고    scopus 로고
    • Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
    • N. Minhas, M. Xue, K. Fukudome, and C.J. Jackson Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function FASEB J 24 2010 873 881
    • (2010) FASEB J , vol.24 , pp. 873-881
    • Minhas, N.1    Xue, M.2    Fukudome, K.3    Jackson, C.J.4
  • 19
    • 79952066363 scopus 로고    scopus 로고
    • Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes
    • L.J. Toltl, R.C. Austin, and P.C. Liaw Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes J Thromb Haemost 9 2011 582 592
    • (2011) J Thromb Haemost , vol.9 , pp. 582-592
    • Toltl, L.J.1    Austin, R.C.2    Liaw, P.C.3
  • 20
    • 77953202368 scopus 로고    scopus 로고
    • The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
    • C. Cao, Y. Gao, Y. Li, T.M. Antalis, F.J. Castellino, and L. Zhang The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b J Clin Invest 120 2010 1971 1980
    • (2010) J Clin Invest , vol.120 , pp. 1971-1980
    • Cao, C.1    Gao, Y.2    Li, Y.3    Antalis, T.M.4    Castellino, F.J.5    Zhang, L.6
  • 21
    • 65449167251 scopus 로고    scopus 로고
    • Recombinant human activated protein C inhibits integrin-mediated neutrophil migration
    • G.F. Elphick, P.P. Sarangi, Y.-M. Hyun, J.A. Hollenbaugh, A. Ayala, and W.L. Biffl Recombinant human activated protein C inhibits integrin-mediated neutrophil migration Blood 113 2009 4078 4085
    • (2009) Blood , vol.113 , pp. 4078-4085
    • Elphick, G.F.1    Sarangi, P.P.2    Hyun, Y.-M.3    Hollenbaugh, J.A.4    Ayala, A.5    Biffl, W.L.6
  • 24
    • 73049098748 scopus 로고    scopus 로고
    • The discovery of the endothelial cell protein C receptor
    • C.T. Esmon The discovery of the endothelial cell protein C receptor J Thromb Haemost 8 2010 2 5
    • (2010) J Thromb Haemost , vol.8 , pp. 2-5
    • Esmon, C.T.1
  • 25
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • DOI 10.1126/science.1071699
    • M. Riewald, R.J. Petrovan, A. Donner, B.M. Mueller, and W. Ruf Activation of endothelial cell protease activated receptor 1 by the protein C pathway Science 296 2002 1880 1882 (Pubitemid 34596276)
    • (2002) Science , vol.296 , Issue.5574 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 26
    • 17044427680 scopus 로고    scopus 로고
    • Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    • C. Feistritzer, and M. Riewald Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation Blood 105 2005 3178 3184
    • (2005) Blood , vol.105 , pp. 3178-3184
    • Feistritzer, C.1    Riewald, M.2
  • 28
    • 65349138302 scopus 로고    scopus 로고
    • Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccharide-induced septic shock
    • J. Xu, Y. Ji, X. Zhang, M. Drake, and C.T. Esmon Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccharide- induced septic shock J Thromb Haemost 7 2009 851 856
    • (2009) J Thromb Haemost , vol.7 , pp. 851-856
    • Xu, J.1    Ji, Y.2    Zhang, X.3    Drake, M.4    Esmon, C.T.5
  • 29
  • 30
    • 77956372381 scopus 로고    scopus 로고
    • Activated protein C targets CD8 + dendritic cells to reduce the mortality of endotoxemia in mice
    • E. Kerschen, I. Hernandez, M. Zogg, S. Jia, M.J. Hessner, and J.A. Fernandez Activated protein C targets CD8 + dendritic cells to reduce the mortality of endotoxemia in mice J Clin Invest 120 2010 3167 3178
    • (2010) J Clin Invest , vol.120 , pp. 3167-3178
    • Kerschen, E.1    Hernandez, I.2    Zogg, M.3    Jia, S.4    Hessner, M.J.5    Fernandez, J.A.6
  • 31
    • 64849083719 scopus 로고    scopus 로고
    • Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1
    • R.A. Schuepbach, C. Feistritzer, J.A. Fernández, J.H. Griffin, and M. Riewald Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1 Thromb Haemost 101 2009 724 733
    • (2009) Thromb Haemost , vol.101 , pp. 724-733
    • Schuepbach, R.A.1    Feistritzer, C.2    Fernández, J.A.3    Griffin, J.H.4    Riewald, M.5
  • 33
    • 65549087489 scopus 로고    scopus 로고
    • Caveolae are required for protease-selective signaling by protease-activated receptor-1
    • A. Russo, U.J. Soh, M.M. Paing, P. Arora, and J. Trejo Caveolae are required for protease-selective signaling by protease-activated receptor-1 Proc Natl Acad Sci U S A 106 2009 6393 6397
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6393-6397
    • Russo, A.1    Soh, U.J.2    Paing, M.M.3    Arora, P.4    Trejo, J.5
  • 34
    • 41949096728 scopus 로고    scopus 로고
    • Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
    • R.A. Schuepbach, C. Feistritzer, L.F. Brass, and M. Riewald Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin Blood 111 2008 2667 2673
    • (2008) Blood , vol.111 , pp. 2667-2673
    • Schuepbach, R.A.1    Feistritzer, C.2    Brass, L.F.3    Riewald, M.4
  • 36
    • 33646559569 scopus 로고    scopus 로고
    • Roles of protease-activated receptors in a mouse model of endotoxemia
    • DOI 10.1182/blood-2005-08-3130
    • E. Camerer, I. Cornelissen, H. Kataoka, D.N. Duong, Y.W. Zheng, and S.R. Coughlin Roles of protease-activated receptors in a mouse model of endotoxemia Blood 107 2006 3912 3921 (Pubitemid 43726796)
    • (2006) Blood , vol.107 , Issue.10 , pp. 3912-3921
    • Camerer, E.1    Cornelissen, I.2    Kataoka, H.3    Duong, D.N.4    Zheng, Y.-W.5    Coughlin, S.R.6
  • 38
    • 37049012509 scopus 로고    scopus 로고
    • The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
    • DOI 10.1182/blood-2007-06-096651
    • J.S. Bae, L. Yang, C. Manithody, and A.R. Rezaie The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells Blood 110 2007 3909 3916 (Pubitemid 350248446)
    • (2007) Blood , vol.110 , Issue.12 , pp. 3909-3916
    • Bae, J.-S.1    Yang, L.2    Manithody, C.3    Rezaie, A.R.4
  • 39
    • 77953806379 scopus 로고    scopus 로고
    • Thrombin upregulates the angiopoietin-Tie2 Axis: Endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies
    • J.S. Bae, and A.R. Rezaie Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies J Thromb Haemost 8 2010 1107 1115
    • (2010) J Thromb Haemost , vol.8 , pp. 1107-1115
    • Bae, J.S.1    Rezaie, A.R.2
  • 40
    • 79959580714 scopus 로고    scopus 로고
    • The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases
    • A.R. Rezaie The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases IUBMB Life 63 2011 390 396
    • (2011) IUBMB Life , vol.63 , pp. 390-396
    • Rezaie, A.R.1
  • 41
    • 0043240071 scopus 로고    scopus 로고
    • Expression and function of the endothelial protein C receptor in human neutrophils
    • DOI 10.1182/blood-2002-12-3880
    • D.H. Sturn, N.C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C.J. Wiedermann Expression and function of the endothelial protein C receptor in human neutrophils Blood 102 2003 1499 1505 (Pubitemid 36988062)
    • (2003) Blood , vol.102 , Issue.4 , pp. 1499-1505
    • Sturn, D.H.1    Kaneider, N.C.2    Feistritzer, C.3    Djanani, A.4    Fukudome, K.5    Wiedermann, C.J.6
  • 43
    • 30744439278 scopus 로고    scopus 로고
    • Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor
    • C. Feistritzer, B.A. Mosheimer, D.H. Sturn, M. Riewald, J.R. Patsch, and C.J. Wiedermann Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor J Immunol 176 2006 1019 1025 (Pubitemid 43099702)
    • (2006) Journal of Immunology , vol.176 , Issue.2 , pp. 1019-1025
    • Feistritzer, C.1    Mosheimer, B.A.2    Sturn, D.H.3    Riewald, M.4    Patsch, J.R.5    Wiedermann, C.J.6
  • 44
    • 79960622857 scopus 로고    scopus 로고
    • Innate immunity and coagulation
    • C.T. Esmon, J. Xu, and F. Lupu Innate immunity and coagulation J Thromb Haemost 9 Suppl. 1 2011 182 188
    • (2011) J Thromb Haemost , vol.9 , Issue.SUPPL. 1 , pp. 182-188
    • Esmon, C.T.1    Xu, J.2    Lupu, F.3
  • 47
    • 80053617611 scopus 로고    scopus 로고
    • Activated protein C inhibits high mobility group box 1 signaling in endothelial cells
    • J.-S. Bae, and A.R. Rezaie Activated protein C inhibits high mobility group box 1 signaling in endothelial cells Blood 118 2011 3952 3959
    • (2011) Blood , vol.118 , pp. 3952-3959
    • Bae, J.-S.1    Rezaie, A.R.2
  • 48
    • 42549132686 scopus 로고    scopus 로고
    • Protein C: A potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
    • A.F. Shorr, D.R. Nelson, D.L. Wyncoll, K. Reinhart, F. Brunkhorst, and G.M. Vail Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Crit Care 12 2008 R45
    • (2008) Crit Care , vol.12 , pp. 45
    • Shorr, A.F.1    Nelson, D.R.2    Wyncoll, D.L.3    Reinhart, K.4    Brunkhorst, F.5    Vail, G.M.6
  • 49
    • 1842547895 scopus 로고    scopus 로고
    • Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
    • DOI 10.1111/j.1538-7836.2004.00955.x
    • J.F. Dhainaut, S.B. Yan, D.E. Joyce, V. Pettilä, B. Basson, and J.T. Brandt Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation J Thromb Haemost 2 2004 1924 1933 (Pubitemid 40192745)
    • (2004) Journal of Thrombosis and Haemostasis , vol.2 , Issue.11 , pp. 1924-1933
    • Dhainaut, J.-F.1    Yan, S.B.2    Joyce, D.E.3    Pettila, V.4    Basson, B.5    Brandt, J.T.6    Sundin, D.P.7    Levi, M.8
  • 50
    • 63249102278 scopus 로고    scopus 로고
    • Administration of Human Protein-C concentrate prevents apoptotic brain cell death after experimental sepsis
    • N. Memos, A. Betrosian, E. Messaris, M. Boutsikou, A. Kataki, and E. Chatzigianni Administration of Human Protein-C concentrate prevents apoptotic brain cell death after experimental sepsis Brain Res 1264 2009 119 126
    • (2009) Brain Res , vol.1264 , pp. 119-126
    • Memos, N.1    Betrosian, A.2    Messaris, E.3    Boutsikou, M.4    Kataki, A.5    Chatzigianni, E.6
  • 52
    • 80054966991 scopus 로고    scopus 로고
    • Protein C Concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation
    • D. Frommhold, J. Tschada, N. Braach, K. Buschmann, A. Doerner, and J. Pflaum Protein C Concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation Am J Pathol 179 2011 2637 2650
    • (2011) Am J Pathol , vol.179 , pp. 2637-2650
    • Frommhold, D.1    Tschada, J.2    Braach, N.3    Buschmann, K.4    Doerner, A.5    Pflaum, J.6
  • 53
    • 33646082484 scopus 로고    scopus 로고
    • Treatment of adult patients with sepsis-induced coagulopathy and purpura fulminans using a plasma-derived protein C concentrate (Ceprotin)
    • P. Schellongowski, E. Bauer, U. Holzinger, T. Staudinger, M. Frass, and K. Laczika Treatment of adult patients with sepsis-induced coagulopathy and purpura fulminans using a plasma-derived protein C concentrate (Ceprotin) Vox Sang 90 2006 294 301
    • (2006) Vox Sang , vol.90 , pp. 294-301
    • Schellongowski, P.1    Bauer, E.2    Holzinger, U.3    Staudinger, T.4    Frass, M.5    Laczika, K.6
  • 54
    • 77955685646 scopus 로고    scopus 로고
    • Human protein C concentrate in the treatment of purpura fulminans: A retrospective analysis of safety and outcome in 94 pediatric patients
    • A. Veldman, D. Fischer, F.Y. Wong, W. Kreuz, M. Sasse, and B. Eberspächer Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients Crit Care 14 2010 R156
    • (2010) Crit Care , vol.14 , pp. 156
    • Veldman, A.1    Fischer, D.2    Wong, F.Y.3    Kreuz, W.4    Sasse, M.5    Eberspächer, B.6
  • 55
    • 0038128677 scopus 로고    scopus 로고
    • Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study
    • DOI 10.1097/01.CCM.0000072121.61120.D8
    • E.D. de Kleijn, R. de Groot, C.E. Hack, P.G. Mulder, W. Engl, and B. Moritz Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study Crit Care Med 31 2003 1839 1847 (Pubitemid 36714245)
    • (2003) Critical Care Medicine , vol.31 , Issue.6 , pp. 1839-1847
    • De Kleijn, E.D.1    De Groot, R.2    Hack, C.E.3    Mulder, P.G.H.4    Engl, W.5    Moritz, B.6    Joosten, K.F.M.7    Hazelzet, J.A.8
  • 57
    • 73949120324 scopus 로고    scopus 로고
    • Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery
    • M. Crivellari, P. Della Valle, G. Landoni, F. Pappalardo, C. Gerli, and E. Bignami Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery Intensive Care Med 35 2009 1959 1963
    • (2009) Intensive Care Med , vol.35 , pp. 1959-1963
    • Crivellari, M.1    Della Valle, P.2    Landoni, G.3    Pappalardo, F.4    Gerli, C.5    Bignami, E.6
  • 58
    • 77957707995 scopus 로고    scopus 로고
    • Protein C concentrate as adjuvant treatment in neonates with sepsis-induced coagulopathy: A pilot study
    • L. Decembrino, A. D'Angelo, F. Manzato, A. Solinas, F. Tumminelli, and A. De Silvestri Protein C concentrate as adjuvant treatment in neonates with sepsis-induced coagulopathy: a pilot study Shock 34 2010 341 345
    • (2010) Shock , vol.34 , pp. 341-345
    • Decembrino, L.1    D'Angelo, A.2    Manzato, F.3    Solinas, A.4    Tumminelli, F.5    De Silvestri, A.6


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