High-Affinity, Selective σ Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties

ChemMedChem

Volumn 7, Issue 3, 2012, Pages 523-532

  Tacke, Reinhold ^a   Bertermann, Rüdiger ^a   Burschka, Christian ^a   Dörrich, Steffen ^a   Fischer, Markus ^a   Müller, Barbara ^a   Meyerhans, Géraldine ^b   Schepmann, Dirk ^b   Wünsch, Bernhard ^b   Arnason, Ingvar ^c   Bjornsson, Ragnar ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF ICELAND   (Iceland)

Author keywords

receptors; Ligands; Sila drugs; Silicon; Spiro compounds

Indexed keywords

1,2,3,4 TETRAHYDRO 1,4' SILASPIRO[NAPHTHALENE 1,4' PIPERIDINE; CARBON; LIGAND; RADIOLIGAND; SIGMA LIGAND; SPIRO COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; X RAY DIFFRACTION;

ANIMALS; BINDING SITES; BRAIN; CARBON; CRYSTALLOGRAPHY, X-RAY; GUINEA PIGS; HUMANS; LIGANDS; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NAPHTHALENES; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; SILICON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857715195     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100423     Document Type: Article

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