Serotonin: A double-edged sword for the liver?

Surgeon

Volumn 10, Issue 2, 2012, Pages 107-113

  Lesurtel, M ^a   Soll, C ^a   Humar, B ^a   Clavien, P A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Liver; Liver diseases; Liver regeneration; Serotonin

Indexed keywords

SEROTONIN; SEROTONIN AGONIST;

DRUG EFFECT; HUMAN; LIVER; LIVER DISEASE; LIVER REGENERATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

HUMANS; LIVER; LIVER DISEASES; LIVER REGENERATION; SEROTONIN; SEROTONIN RECEPTOR AGONISTS;

EID: 84857686161     PISSN: 1479666X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surge.2011.11.002     Document Type: Review

References (56)

1. Hoyer D., Hannon J.P., Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002, 71(4):533-554.
2. Thompson J.H. Serotonin and the alimentary tract. Res Commun Chem Pathol Pharmacol 1971, 2(4):687-781.
3. Lembeck F. 5-hydroxytryptamine in a carcinoid tumor. Nature 1953, 172:910.
4. Eddahibi S., Raffestin B., Pham I., Launay J.M., Aegerter P., Sitbon M., et al. Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats. Am J Physiol 1997, 272(3 Pt 2):H1173-H1181.
5. Fanburg B.L., Lee S.L. A new role for an old molecule: serotonin as a mitogen. Am J Physiol 1997, 272(5 Pt 1):L795-L806.
6. Matsuda M., Imaoka T., Vomachka A.J., Gudelsky G.A., Hou Z., Mistry M., et al. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Dev Cell 2004, 6(2):193-203.
7. Lesurtel M., Graf R., Aleil B., Walther D.J., Tian Y., Jochum W., et al. Platelet-derived serotonin mediates liver regeneration. Science 2006, 312(5770):104-107.
8. Lesurtel M., Soll C., Graf R., Clavien P.A. Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives. Cell Mol Life Sci 2008, 65(6):940-952.
9. Tyce G.M. Origin and metabolism of serotonin. J Cardiovasc Pharmacol 1990, 16(Suppl. 3):S1-S7.
10. Walther D.J., Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 2003, 66(9):1673-1680.
11. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., et al. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299(5603):76.
12. Barnes N.M., Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999, 38(8):1083-1152.
13. Raymond J.R., Mukhin Y.V., Gelasco A., Turner J., Collinsworth G., Gettys T.W., et al. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 2001, 92(2-3):179-212.
14. Clavien P.A., Petrowsky H., DeOliveira M.L., Graf R. Strategies for safer liver surgery and partial liver transplantation. N Engl J Med 2007, 356(15):1545-1559.
15. Fausto N., Campbell J.S., Riehle K.J. Liver regeneration. Hepatology 2006, 43(2 Suppl. 1):S45-S53.
16. Witters P., Freson K., Verslype C., Peerlinck K., Hoylaerts M., Nevens F., et al. Review article: blood platelet number and function in chronic liver disease and cirrhosis. Aliment Pharmacol Ther 2008, 27(11):1017-1029.
17. Poordad F. Review article: thrombocytopenia in chronic liver disease. Aliment Pharmacol Ther 2007, 26(Suppl. 1):5-11.
18. Matsumoto K., Nakamura T. Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog 1992, 3(1-2):27-54.
19. Raines E.W., Ross R. Purification of human platelet-derived growth factor. Methods Enzymol 1985, 109:749-773.
20. Assoian R.K., Grotendorst G.R., Miller D.M., Sporn M.B. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 1984, 309(5971):804-806.
21. Kuwashima Y., Aoki K., Kohyama K., Ishikawa T. Hepatocyte regeneration after partial hepatectomy occurs even under severely thrombocytopenic conditions in the rat. Jpn J Cancer Res 1990, 81(6-7):607-612.
22. Tomikawa M., Hashizume M., Highashi H., Ohta M., Sugimachi K. The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats. J Am Coll Surg 1996, 182(1):12-16.
23. Murata S., Ohkohchi N., Matsuo R., Ikeda O., Myronovych A., Hoshi R. Platelets promote liver regeneration in early period after hepatectomy in mice. World J Surg 2007, 31(4):808-816.
24. Matsuo R., Ohkohchi N., Murata S., Ikeda O., Nakano Y., Watanabe M., et al. Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro. J Surg Res 2008, 145(2):279-286.
25. Murata S., Matsuo R., Ikeda O., Myronovych A., Watanabe M., Hisakura K., et al. Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice. World J Surg 2008, 32(6):1088-1096.
26. Myronovych A., Murata S., Chiba M., Matsuo R., Ikeda O., Watanabe M., et al. Role of platelets on liver regeneration after 90% hepatectomy in mice. J Hepatol 2008, 49(3):363-372.
27. Matsuo R., Nakano Y., Ohkohchi N. Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy. Ann Surg 2011, 253(4):759-763.
28. Alkozai E.M., Nijsten M.W., de Jong K.P., de Boer M.T., Peeters P.M., Slooff M.J., et al. Immediate postoperative low platelet count is associated with delayed liver function recovery after partial liver resection. Ann Surg 2010, 251(2):300-306.
29. Kim J., Yi N.J., Shin W.Y., Kim T., Lee K.U., Suh K.S. Platelet transfusion can be related to liver regeneration after living donor liver transplantation. World J Surg 2010, 34(5):1052-1058.
30. Aslamova L.I., Blium Ia B., Tsudzevich B.A., Kucherenko N.E. Cyclic nucleotide levels in the regenerating liver of rats following irradiation and protection by serotonin. Radiobiologiia 1985, 25(3):324-327.
31. Kulinskii A.S., Saratikov A.S., Vstavskaia Iu A., Udovitsina T.I. Effect of substances altering the metabolism of endogenous serotonin on mitotic activity in the regenerating liver of mice. Farmakol Toksikol 1983, 46(2):92-95.
32. Papadimas G.K., Tzirogiannis K.N., Panoutsopoulos G.I., Demonakou M.D., Skaltsas S.D., Hereti R.I., et al. Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver. Liver Int 2006, 26(3):352-361.
33. Tian Y., Graf R., El-Badry A.M., Lesurtel M., Furrer K., Moritz W., et al. Activation of serotonin receptor-2B rescues small-for-size liver graft failure in mice. Hepatology 2011, 53(1):253-262.
34. Furrer K., Rickenbacher A., Tian Y., Jochum W., Bittermann A.G., Kach A., et al. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Proc Natl Acad Sci U S A 2011, 108(7):2945-2950.
35. Matondo R.B., Punt C., Homberg J., Toussaint M.J., Kisjes R., Korporaal S.J., et al. Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration. Am J Physiol Gastrointest Liver Physiol 2009, 296(4):G963-G968.
36. Hernandez-Gea V., Friedman S.L. Pathogenesis of liver fibrosis. Annu Rev Pathol 2011, 6:425-456.
37. Schuppan D., Afdhal N.H. Liver cirrhosis. Lancet 2008, 371(9615):838-851.
38. Xu Y., Huo Y., Toufektsian M.C., Ramos S.I., Ma Y., Tejani A.D., et al. Activated platelets contribute importantly to myocardial reperfusion injury. Am J Physiol Heart Circ Physiol 2006, 290(2):H692-H699.
39. Okada Y., Marchevsky A.M., Zuo X.J., Pass J.A., Kass R.M., Matloff J.M., et al. Accumulation of platelets in rat syngeneic lung transplants: a potential factor responsible for preservation-reperfusion injury. Transplantation 1997, 64(6):801-806.
40. Kuroda T., Shiohara E., Homma T., Furukawa Y., Chiba S. Effects of leukocyte and platelet depletion on ischemia-reperfusion injury to dog pancreas. Gastroenterology 1994, 107(4):1125-1134.
41. Khandoga A., Biberthaler P., Enders G., Teupser D., Axmann S., Luchting B., et al. P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock 2002, 18(6):529-535.
42. Yadav S.S., Howell D.N., Steeber D.A., Harland R.C., Tedder T.F., Clavien P.A. P-Selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. Hepatology 1999, 29(5):1494-1502.
43. Khandoga A., Biberthaler P., Enders G., Axmann S., Hutter J., Messmer K., et al. Platelet adhesion mediated by fibrinogen-intercelllular adhesion molecule-1 binding induces tissue injury in the postischemic liver in vivo. Transplantation 2002, 74(5):681-688.
44. Murata R., Hamada N., Nakamura N., Kobayashi A., Fukueda M., Taira A., et al. Serotonin activity and liver dysfunction following hepatic ischemia and reperfusion. In Vivo 2003, 17(6):567-572.
45. Nocito A., Georgiev P., Dahm F., Jochum W., Bader M., Graf R., et al. Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice. Hepatology 2007, 45(2):369-376.
46. Marzioni M., Glaser S., Francis H., Marucci L., Benedetti A., Alvaro D., et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 2005, 128(1):121-137.
47. Omenetti A., Yang L., Gainetdinov R.R., Guy C.D., Choi S.S., Chen W., et al. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. Am J Physiol Gastrointest Liver Physiol 2011, 300(2):G303-G315.
48. Bergasa N.V. Pruritus and fatigue in primary biliary cirrhosis. Clin Liver Dis 2003, 7(4):879-900.
49. Swain M.G., Maric M. Improvement in cholestasis-associated fatigue with a serotonin receptor agonist using a novel rat model of fatigue assessment. Hepatology 1997, 25(2):291-294.
50. Jones E.A., Molenaar H.A., Oosting J. Ondansetron and pruritus in chronic liver disease: a controlled study. Hepatogastroenterology 2007, 54(76):1196-1199.
51. Day C.P., James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 1998, 114(4):842-845.
52. Nocito A., Dahm F., Jochum W., Jang J.H., Georgiev P., Bader M., et al. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Gastroenterology 2007, 133(2):608-618.
53. Lang P.A., Contaldo C., Georgiev P., El-Badry A.M., Recher M., Kurrer M., et al. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 2008, 14(7):756-761.
54. Ruddell R.G., Oakley F., Hussain Z., Yeung I., Bryan-Lluka L.J., Ramm G.A., et al. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol 2006, 169(3):861-876.
55. Alpini G., Invernizzi P., Gaudio E., Venter J., Kopriva S., Bernuzzi F., et al. Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. Cancer Res 2008, 68(22):9184-9193.
56. Soll C., Jang J.H., Riener M.O., Moritz W., Wild P.J., Graf R., et al. Serotonin promotes tumor growth in human hepatocellular cancer. Hepatology 2010, 51(4):1244-1254.