Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells

Journal of Functional Foods

Volumn 4, Issue 1, 2012, Pages 185-196

  González Sarrías, Antonio ^a   Li, Liya ^a   Seeram, Navindra P ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Antiproliferative; Apoptosis; Cell cycle; Cyclins; Maple syrup; Phenolics

Indexed keywords

ACER;

EID: 84857685986     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2011.10.004     Document Type: Article

References (31)

1. Al-Ayyoubi S., Gali-Muhtasib H. Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. Molecular Carcinogenesis 2007, 46:176-186.
2. Apostolidis E., Li L., Lee C., Seeram N.P. In vitro evaluation of phenolic-enriched maple syrup extracts for inhibition of carbohydrate hydrolyzing enzymes relevant to type 2 diabetes management. Journal of Functional Foods 2011, 3:100-106.
3. Ball D.W. The chemical composition of maple syrup. Journal of Chemical Education 2007, 84:1647-1650.
4. Cilla A., González-Sarrías A., Tomás-Barberán F.A., Espín J.C., Barberá R. Availability of polyphenols in fruit beverages subjected to in vitro gastrointestinal digestion and their effects on proliferation, cell cycle and apoptosis in human colon cancer Caco-2 cells. Food Chemistry 2009, 114:813-820.
5. González-Sarrías A., Espín J.C., Tomás-Barberán F.A., García-Conesa M.T. Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic and its metabolites, urolithins. Molecular Nutrition Food Research 2009, 53:686-698.
6. Guil-Guerrero J.L., Ramos-Bueno R., Rodríguez-García I., López-Sánchez C. Cytotoxicity screening of several tomato extracts. Journal of Medicinal Food 2011, 14:40-45.
7. Hartwell L.H., Kastan M.B. Cell cycle control and cancer. Science 1994, 266:1821-1828.
8. Hitomi M., Stacey D.W. Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells. Molecular Cell Biology 1999, 19:4623-4632.
9. Jemal A., Siegel R., Xu J., Ward E. Cancer statistics. CA Cancer Journal Clinical 2010, 60:277-300.
10. Kern M., Pahlke G., Balavenkatraman K.K., Böhmer F.D., Marko D. Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. Journal of Agricultural and Food Chemistry 2007, 55:4999-5006.
11. Larrosa M., Tomás-Barberán F.A., Espín J.C. The dietary hydrolysable tannin punicalagin releases ellagic acid which induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. Journal of Nutritional Biochemistry 2006, 17:611-625.
12. Legault J., Girard-Lalancette K., Grenon C., Dussault C., Pichette A. Antioxidant activity, inhibition of nitric oxide overproduction, and in vitro antiproliferative effect of maple sap and syrup from Acer saccharum. Journal of Medicinal Food 2010, 13:460-468.
13. Li L., Henry G.E., Seeram N.P. Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. Journal of Agricultural and Food Chemistry 2009, 57:7282-7287.
14. Li S., Pan M.-H., Lo C.-Y., Tan D., Wanga Y., Shahidi F., Co C.-H. Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones. Journal of Functional Foods 2009, 1:2-12.
15. Li L., Seeram N.P. Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds. Journal of Agricultural and Food Chemistry 2010, 58:11673-11679.
16. Li L., Seeram N.P. Further investigation into maple syrup yields three new lignans, a new phenylpropanoid, and twenty-six other phytochemicals. Journal of Agricultural and Food Chemistry 2011, 59:7708-7716.
17. Li L., Seeram N.P. Quebecol, a novel phenolic compound isolated from Canadian maple syrup. Journal of Functional Foods 2011, 3:125-128.
18. Liu R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. American Journal of Clinical Nutrition 2003, 78:517S-520S.
19. McWilliams R.R., Erlichman C. Novel therapeutics in colorectal cancer. Diseases of the Colon and Rectum 2005, 48:1632-1650.
20. Noratto G.D., Bertoldi M.C., Krenek K., Talcott S.T., Stringheta P.C., Mertens-Talcott S.U. Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties. Journal of Agricultural and Food Chemistry 2010, 58:4104-4112.
21. Pagano M., Pepperkok R., Verde F., Ansorge W., Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO Journal 1992, 11:961-971.
22. Perkins T.D., van den Berg A.K. Maple syrup - production, composition, chemistry, and sensory characteristics. Advances in Food & Nutrition Research 2009, 56:101-143.
23. Rudolf E., Andelová H., Cervinka M. Polyphenolic compounds in chemoprevention of colon cancer-targets and signaling pathways. Anticancer Agents in Medicinal Chemistry 2007, 7:559-575.
24. Salucci M., Stivala L.A., Maiani G., Bugianesi R., Vannini V. Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). British Journal of Cancer 2002, 86:1645-1651.
25. Seeram N.P., Adams L.S., Hardy L., Heber D. Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumour cell lines. Journal of Agricultural and Food Chemistry 2004, 52:2512-2517.
26. Seeram N.P., Lee R., Hardy M.L., Heber D. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Separation and Purification Technology 2005, 41:49-55.
27. Shahidi F., Ho C.-T. Phenolic compounds in foods and natural health products 2005, American Chemical Society Symposium Series 909, Washington, DC, USA.
28. Sharma M., Li L., Celver J., Killian C., Kovoor A., Seeram N.P. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signaling. Journal of Agricultural and Food Chemistry 2010, 58:3965-3969.
29. Théirault M., Caillet S., Kermasha S., Lacroix M. Antioxidant, antiradical and antimutagenic activities of phenolic compounds present in maple products. Food Chemistry 2006, 98:490-501.
30. Visanji J.M., Thompson D.G., Padfield P.J. Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Letters 2006, 237:130-136.
31. Zhao C., Giusti M.M., Malik M., Moyer M.P., Magnuson B.A. Effects of commercial anthocyanin-rich extracts on colonic cancer and non-tumourigenic colonic cell growth. Journal of Agricultural and Food Chemistry 2004, 52:6122-6128.