Identification of antigen-specific antibody responses associated with upper genital tract pathology in mice infected with Chlamydia muridarum

Infection and Immunity

Volumn 80, Issue 3, 2012, Pages 1098-1106

  Zeng, Hao ^a,b   Gong, Siqi ^a   Hou, Shuping ^a   Zou, Quanming ^b   Zhong, Guangming ^a  

^a University of Texas Health Science Center   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; EPITOPE; HYBRID PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ABSORPTION; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; CHLAMYDIA; CHLAMYDIA TRACHOMATIS; CHLAMYDIAL URETHRITIS; DIFFERENTIATION; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE DISEASE; FEMALE; GENE; GENITAL TRACT INFECTION; HUMAN; HUMAN CELL; HYDROSALPINX; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVIDUCT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; VAGINA; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CHLAMYDIA INFECTIONS; CHLAMYDIA MURIDARUM; FEMALE; GENITALIA, FEMALE; MICE; MICE, INBRED C57BL; REPRODUCTIVE TRACT INFECTIONS; VIRULENCE FACTORS;

EID: 84857681416     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05894-11     Document Type: Article

References (65)

1. Ajonuma LC, Ng EH, Chan HC. 2002. New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome. Hum. Reprod. Update 8:255-264.
2. Arno JN, Yuan Y, Cleary RE, Morrison RP. 1995. Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (hsp60). Fertil. Steril. 64:730-735.
3. Ault KA, et al. 1998. Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility. Infect. Dis. Obstet. Gynecol. 6:163-167.
4. Beatty WL, Byrne GI, Morrison RP. 1994. Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease. Trends Microbiol. 2:94-98.
5. Betts-Hampikian HJ, Fields KA. 2010. The chlamydial type III secretion mechanism: revealing cracks in a tough nut. Front. Microbiol. 1:114.
6. Brunham RC, Maclean IW, Binns B, Peeling RW. 1985. Chlamydia trachomatis: its role in tubal infertility. J. Infect. Dis. 152:1275-1282.
7. Caetano ME, et al. 2010. Sexual behavior and knowledge of sexually transmitted infections among university students in Sao Paulo, Brazil. Int. J. Gynaecol. Obstet. 110:43-46.
8. Campanella C, et al. 2009. A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response. Int. J. Immunogenet. 36:73-78.
9. Carlson JH, Porcella SF, McClarty G, Caldwell HD. 2005. Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains. Infect. Immun. 73:6407-6418.
10. Carlson JH, et al. 2008. The Chlamydia trachomatis plasmid is a transcriptional regulator of chromosomal genes and a virulence factor. Infect. Immun. 76:2273-2283.
11. Carrasco JA, Tan C, Rank RG, Hsia RC, Bavoil PM. 2011. Altered developmental expression of polymorphic membrane proteins in penicillin-stressed Chlamydia trachomatis. Cell Microbiol. 13:1014-1025.
12. Chen L, et al. 2010. Mice deficient in MyD88 develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J. Immunol. 184:2602-2610.
13. Cheng W, et al. 2008. Caspase-1 contributes to Chlamydia trachomatisinduced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect. Immun. 76:515-522.
14. Cheng W, et al. 2008. Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor. Infect. Immun. 76:942-951.
15. Confino E, et al. 1990. Transcervical balloon tuboplasty. A multicenter study. JAMA 264:2079-2082.
16. Crane DD, et al. 2006. Chlamydia trachomatis polymorphic membrane protein D is a species-common pan-neutralizing antigen. Proc. Natl. Acad. Sci. U. S. A. 103:1894-1899.
17. Cruz-Fisher MI, et al. 2011. Identification of immunodominant antigens by probing a whole Chlamydia trachomatis open reading frame proteome microarray using sera from immunized mice. Infect. Immun. 79:246-257.
18. Dadamessi I, Eb F, Betsou F. 2005. Combined detection of Chlamydia trachomatis-specific antibodies against the 10 and 60-kDa heat shock proteins as a diagnostic tool for tubal factor infertility: results from a casecontrol study in Cameroon. FEMS Immunol. Med. Microbiol. 45:31-35.
19. Dieterle S, Wollenhaupt J. 1996. Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. Hum. Reprod. 11:1352-1356.
20. Fling SP, et al. 2001. CD8+ T cells recognize an inclusion membraneassociated protein from the vacuolar pathogen Chlamydia trachomatis. Proc. Natl. Acad. Sci. U. S. A. 98:1160-1165.
21. Gerard HC, Whittum-Hudson JA, Schumacher HR, Hudson AP. 2004. Differential expression of three Chlamydia trachomatis hsp60-encoding genes in active vs. persistent infections. Microb. Pathog. 36:35-39.
22. Gong S, Lei L, Chang X, Belland R, Zhong G. 2011. Chlamydia trachomatis secretion of hypothetical protein CT622 into host cell cytoplasm via a secretion pathway that can be inhibited by the type III secretion system inhibitor compound 1. Microbiology 157:1134-1144.
23. Grant A. 1971. Infertility surgery of the oviduct. Fertil. Steril. 22:496-503.
24. Hobolt-Pedersen AS, Christiansen G, Timmerman E, Gevaert K, Birkelund S. 2009. Identification of Chlamydia trachomatis CT621, a protein delivered through the type III secretion system to the host cell cytoplasm and nucleus. FEMS Immunol. Med. Microbiol. 57:46-58.
25. Kari L, et al. 2008. Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations. J. Infect. Dis. 197:449-456.
26. Karinen L, et al. 2004. Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31. Am. J. Reprod. Immunol. 52:291-297.
27. Karinen L, et al. 2004. Association between Chlamydia trachomatis antibodies and subfertility in the Northern Finland Birth Cohort 1966 (NFBC 1966), at the age of 31 years. Epidemiol. Infect. 132:977-984.
28. Kinnunen A, et al. 2002. Chlamydial heat shock protein 60-specific T cells in inflamed salpingeal tissue. Fertil. Steril. 77:162-166.
29. Kinnunen A, et al. 2003. Chlamydia trachomatis heat shock protein-60 induced interferon-gamma and interleukin-10 production in infertile women. Clin. Exp. Immunol. 131:299-303.
30. LaVerda D, Kalayoglu MV, Byrne GI. 1999. Chlamydial heat shock proteins and disease pathology: new paradigms for old problems? Infect. Dis. Obstet. Gynecol. 7:64-71.
31. Lee HY, et al. 2010. A role for CXC chemokine receptor-2 in the pathogenesis of urogenital Chlamydia muridarum infection in mice. FEMS Immunol. Med. Microbiol. 60:49-56.
32. Lee HY, et al. 2010. A link between neutrophils and chronic disease manifestations of Chlamydia muridarum urogenital infection of mice. FEMS Immunol. Med. Microbiol. 59:108-116.
33. Li Z, et al. 2008. Characterization of fifty putative inclusion membrane proteins encoded in the Chlamydia trachomatis genome. Infect. Immun. 76:2746-2757.
34. Li Z, et al. 2008. Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner. BMC Microbiol. 8:90.
35. Linhares IM, Witkin SS. 2010. Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract. Cell Stress Chaperones 15:467-473.
36. Malik A, Jain S, Rizvi M, Shukla I, Hakim S. 2009. Chlamydia trachomatis infection in women with secondary infertility. Fertil. Steril. 91:91-95.
37. Morrison RP. 1991. Chlamydial hsp60 and the immunopathogenesis of chlamydial disease. Semin. Immunol. 3:25-33.
38. Morrison RP, Caldwell HD. 2002. Immunity to murine chlamydial genital infection. Infect. Immun. 70:2741-2751.
39. O'Connell CM, Ingalls RR, Andrews CW, Jr, Scurlock AM, Darville T. 2007. Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease. J. Immunol. 179:4027-4034.
40. Olivares-Zavaleta N, Whitmire W, Gardner D, Caldwell HD. 2010. Immunization with the attenuated plasmidless Chlamydia trachomatis L2(25667R) strain provides partial protection in a murine model of female genitourinary tract infection. Vaccine 28:1454-1462.
41. Pal S, Davis HL, Peterson EM, de la Maza LM. 2002. Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein by use of CpG oligodeoxynucleotides as an adjuvant induces a protective immune response against an intranasal chlamydial challenge. Infect. Immun. 70:4812-4817.
42. Perez Melgosa M, Kuo CC, Campbell LA. 1994. Isolation and characterization of a gene encoding a Chlamydia pneumoniae 76-kilodalton protein containing a species-specific epitope. Infect. Immun. 62:880-886.
43. Ramsey KH, et al. 2009. Strain and virulence diversity in the mouse pathogen Chlamydia muridarum. Infect. Immun. 77:3284-3293.
44. Read TD, et al. 2000. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res. 28:1397-1406.
45. Rockey DD, Scidmore MA, Bannantine JP, Brown WJ. 2002. Proteins in the chlamydial inclusion membrane. Microbes Infect. 4:333-340.
46. Rodgers AK, et al. 2011. Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility. Fertil. Steril. 96:715-721.
47. Rodgers AK, et al. 2010. Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. Am. J. Obstet. Gynecol. 203:494 e497-494 e414.
48. Shah AA, et al. 2005. Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum. Sex. Transm. Dis. 32:49-56.
49. Sharma J, Bosnic AM, Piper JM, Zhong G. 2004. Human antibody responses to a Chlamydia-secreted protease factor. Infect. Immun. 72:7164-7171.
50. Sharma J, et al. 2006. Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect. Immun. 74:1490-1499.
51. Sharma M, Sethi S, Daftari S, Malhotra S. 2003. Evidence of chlamydial infection in infertile women with fallopian tube obstruction. Indian J. Pathol. Microbiol. 46:680-683.
52. Stephens RS. 2003. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol. 11:44-51.
53. Sziller I, et al. 2008. Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60-kDa heat shock protein is associated with decreased spontaneous fertility rate in ectopic pregnant women treated by salpingectomy. Am. J. Reprod. Immunol. 59:99-104.
54. Tiitinen A, et al. 2006. Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility. Hum. Reprod. 21:1533-1538.
55. Toye B, Laferriere C, Claman P, Jessamine P, Peeling R. 1993. Association between antibody to the chlamydial heat-shock protein and tubal infertility. J. Infect. Dis. 168:1236-1240.
56. Valdivia RH. 2008. Chlamydia effector proteins and new insights into chlamydial cellular microbiology. Curr. Opin. Microbiol. 11:53-59.
57. Wang J, et al. 2009. A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity in mice against inflammatory pathologies in the upper genital tract. Vaccine 27:2967-2980.
58. Wang J, et al. 2010. A genome-wide profiling of the humoral immune response to Chlamydia trachomatis infection reveals vaccine candidate antigens expressed in humans. J. Immunol. 185:1670-1680.
59. Wang J, Zhang Y, Yu P, Zhong G. 2010. Immunodominant regions of a Chlamydia trachomatis type III secretion effector protein, Tarp. Clin. Vaccine Immunol. 17:1371-1376.
60. Witkin SS, Jeremias J, Toth M, Ledger WJ. 1993. Cell-mediated immune response to the recombinant 57-kDa heat-shock protein of Chlamydia trachomatis in women with salpingitis. J. Infect. Dis. 167:1379-1383.
61. Zhong G. 2009. Killing me softly: chlamydial use of proteolysis for evading host defenses. Trends Microbiol. 17:467-474.
62. Zhong G, et al. 2011. Chlamydia-secreted proteins in chlamydial interactions with host cells. Curr. Chem. Biol. 5:9.
63. Zhong G, Fan P, Ji H, Dong F, Huang Y. 2001. Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J. Exp. Med. 193:935-942.
64. Zhong G, Reis e Sousa C, Germain RN. 1997. Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proc. Natl. Acad. Sci. U. S. A. 94:13856-13861.
65. Zhong G, Toth I, Reid R, Brunham RC. 1993. Immunogenicity evaluation of a lipidic amino acid-based synthetic peptide vaccine for Chlamydia trachomatis. J. Immunol. 151:3728-3736.