Immunodominant regions of a Chlamydia trachomatis type III secretion effector protein, Tarp

Clinical and Vaccine Immunology

Volumn 17, Issue 9, 2010, Pages 1371-1376

  Wang, Jie ^a   Zhang, Yingqian ^b   Yu, Ping ^a   Zhong, Guangming ^b  

^a Central South University   (China)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; BACTERIAL PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MONOCLONAL ANTIBODY; PROTEIN TARP; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; CHLAMYDIA TRACHOMATIS; CLINICAL ARTICLE; EPITOPE MAPPING; FEMALE; GENE SEQUENCE; HOST CELL; HUMAN; HUMAN TISSUE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEROTYPE; SEXUALLY TRANSMITTED DISEASE; TRACHOMA; TYPE III SECRETION SYSTEM;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; EPITOPE MAPPING; FEMALE; FEMALE UROGENITAL DISEASES; HUMANS; IMMUNODOMINANT EPITOPES; MICE; MICE, INBRED BALB C; RABBITS; VIRULENCE FACTORS;

EID: 77956401322     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00218-10     Document Type: Article

References (21)

1. Backert, S., and M. Selbach. 2005. Tyrosine-phosphorylated bacterial effector proteins: the enemies within. Trends Microbiol. 13:476-484.
2. Bauwens, J. E., H. Orlander, M. P. Gomez, M. Lampe, S. Morse, W. E. Stamm, R. Cone, R. Ashley, P. Swenson, and K. K. Holmes. 2002. Epidemic lymphogranuloma venereum during epidemics of crack cocaine use and HIV infection in the Bahamas. Sex. Transm. Dis. 29:253-259.
3. Cheng, W., P. Shivshankar, Z. Li, L. Chen, I. T. Yeh, and G. Zhong. 2008. Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect. Immun. 76:515-522.
4. Clifton, D. R., K. A. Fields, S. S. Grieshaber, C. A. Dooley, E. R. Fischer, D. J. Mead, R. A. Carabeo, and T. Hackstadt. 2004. A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin. Proc. Natl. Acad. Sci. U. S. A. 101:10166-10171.
5. Clifton, D. R., C. A. Dooley, S. S. Grieshaber, R. A. Carabeo, K. A. Fields, and T. Hackstadt. 2005. Tyrosine phosphorylation of the chlamydial effector protein Tarp is species specific and not required for recruitment of actin. Infect. Immun. 73:3860-3868.
6. Engel, J. 2004. Tarp and Arp: how Chlamydia induces its own entry. Proc. Natl. Acad. Sci. U. S. A. 101:9947-9948.
7. Hackstadt, T. 1998. The diverse habitats of obligate intracellular parasites. Curr. Opin. Microbiol. 1:82-87.
8. Jewett, T. J., E. R. Fischer, D. J. Mead, and T. Hackstadt. 2006. Chlamydial TARP is a bacterial nucleator of actin. Proc. Natl. Acad. Sci. U. S. A. 103:15599-15604.
9. Jewett, T. J., C. A. Dooley, D. J. Mead, and T. Hackstadt. 2008. Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases. Biochem. Biophys. Res. Commun. 371:339-344.
10. Kinnunen, A. H., H. M. Surcel, M. Lehtinen, J. Karhukorpi, A. Tiitinen, M. Halttunen, A. Bloigu, R. P. Morrison, R. Karttunen, and J. Paavonen. 2002. HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study. Hum. Reprod. 17:2073-2078.
11. Lane, B. J., C. Mutchler, S. Al Khodor, S. S. Grieshaber, and R. A. Carabeo. 2008. Chlamydial entry involves TARP binding of guanine nucleotide exchange factors. PLoS Pathog. 4:e1000014.
12. Li, Z., Y. Zhong, L. Lei, Y. Wu, S. Wang, and G. Zhong. 2008. Antibodies from women urogenitally infected with C. trachomatis predominantly recognized the plasmid protein pgp3 in a conformation-dependent manner. BMC Microbiol. 8:90.
13. Read, T. D., R. C. Brunham, C. Shen, S. R. Gill, J. F. Heidelberg, O. White, E. K. Hickey, J. Peterson, T. Utterback, K. Berry, S. Bass, K. Linher, J. Weidman, H. Khouri, B. Craven, C. Bowman, R. Dodson, M. Gwinn, W. Nelson, R. DeBoy, J. Kolonay, G. McClarty, S. L. Salzberg, J. Eisen, and C. M. Fraser. 2000. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res. 28:1397-1406.
14. Read, T. D., G. S. Myers, R. C. Brunham, W. C. Nelson, I. T. Paulsen, J. Heidelberg, E. Holtzapple, H. Khouri, N. B. Federova, H. A. Carty, L. A. Umayam, D. H. Haft, J. Peterson, M. J. Beanan, O. White, S. L. Salzberg, R. C. Hsia, G. McClarty, R. G. Rank, P. M. Bavoil, and C. M. Fraser. 2003. Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae. Nucleic Acids Res. 31:2134-2147.
15. Schachter, J., and J. Moncada. 2005. Lymphogranuloma venereum: how to turn an endemic disease into an outbreak of a new disease? Start looking. Sex. Transm. Dis. 32:331-332.
16. Sharma, J., Y. Zhong, F. Dong, J. M. Piper, G. Wang, and G. Zhong. 2006. Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect. Immun. 74:1490-1499.
17. Sherman, K. J., J. R. Daling, A. Stergachis, N. S. Weiss, H. M. Foy, S. P. Wang, and J. T. Grayston. 1990. Sexually transmitted diseases and tubal pregnancy. Sex. Transm. Dis. 17:115-121.
18. Spaargaren, J., J. Schachter, J. Moncada, H. J. de Vries, H. S. Fennema, A. S. Pena, R. A. Coutinho, and S. A. Morre. 2005. Slow epidemic of lymphogranuloma venereum L2b strain. Emerg. Infect. Dis. 11:1787-1788.
19. Stephens, R. S., S. Kalman, C. Lammel, J. Fan, R. Marathe, L. Aravind, W. Mitchell, L. Olinger, R. L. Tatusov, Q. Zhao, E. V. Koonin, and R. W. Davis. 1998. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science 282:754-759.
20. Taylor, H. R., S. L. Johnson, J. Schachter, H. D. Caldwell, and R. A. Prendergast. 1987. Pathogenesis of trachoma: the stimulus for inflammation. J. Immunol. 138:3023-3027.
21. Wang, J., L. Chen, F. Chen, X. Zhang, Y. Zhang, J. Baseman, S. Perdue, I. T. Yeh, R. Shain, M. Holland, R. Bailey, D. Mabey, P. Yu, and G. Zhong. 2009. A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice. Vaccine 27:2967-2980.