Circulating antibodies to a conserved epitope of the chlamydia trachomatis 60-kDa heat shock protein is associated with decreased spontaneous fertility rate in ectopic pregnant women treated by salpingectomy

American Journal of Reproductive Immunology

Volumn 59, Issue 2, 2008, Pages 99-104

  Sziller, István ^a   Fedorcsák, Peter ^a,b   Csapó, Zsolt ^a   Szirmai, Katalin ^a   Linhares, Iara M ^c   Papp, Zoltàn ^a   Witkin, Steven S ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

60 kDa heat shock protein; Chlamydia trachomatis; Conserved epitopes; Ectopic pregnancy; Fertility; Immunity

Indexed keywords

EPITOPE; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 60 ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CLINICAL TRIAL; CONCEPTION; CORRELATION ANALYSIS; ECTOPIC PREGNANCY; FEMALE; FEMALE INFERTILITY; HISTOPATHOLOGY; HOST RESISTANCE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; SALPINGECTOMY;

ANTIBODIES, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; INFERTILITY; PREGNANCY; PREGNANCY, ECTOPIC; PROSPECTIVE STUDIES;

EID: 38349032856     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2007.00553.x     Document Type: Article

References (30)

1. Centers for Disease Control and Prevention: Ectopic pregnancy-United States 1990-1992. Morb Mortal Wkly Rep (MMWR) 1995; 44: 46-48.
2. Sziller I, Ujházy A, Bardóczy Z, Szendei G, Papp Z: Incidence and mortality of ectopic pregnancy in Hungary (1931-1995). Orv Hetil 1998; 139: 493-498.
3. Coste J, Bouyer J, Ughetto S, Gerbaud L, Fernandez H, Pouly JL, Job-Spria N: Ectopic pregnancy is again on the increase. Recent trends in the incidence of ectopic pregnancies in France (1992-2002). Hum Reprod 2004; 19: 2014-2018.
4. Gruft L, Bertola E, Luchini L, Azzilonna C, Bigatti G, Parazzini F: Determinants of reproductive prognosis after ectopic pregnancy. Hum Reprod 1994; 9: 1333-1336.
5. Skjeldestad FE, Hadgu A, Eriksson N: Epidemiology of repeat ectopic pregnancy: A population-based prospective cohort study. Obstet Gynecol 1998; 91: 129-135.
6. Bernoux A, Job-Spira N, Gremain E, Coste J, Bouyer J: Fertility outcome after ectopic pregnancy and use of an intrauterine device at the time of the index ectopic pregnancy. Hum Reprod 2000; 15: 1173-1177.
7. Thorburn J, Philipson M, Lindblom B: Fertility after ectopic pregnancy in relation to background factors and surgical treatment. Fertil Steril 1998; 49: 595-601.
8. Al-Nuaim L, Bamgboye EA, Chowdhury N, Adelusi B: Reproductive potential after an ectopic pregnancy. Fertil Steril 1995; 64: 942-946.
9. Claman P, Honey L, Peeling R, Jessamine P, Toye B: The presence of serum antibody to the chlamydial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility. Fertil Steril 1997; 67: 501-504.
10. Logan S, Gazvani R, McKenzie H, Templeton A, Bhattacharya S: Can history, ultrasound, or ELISA chlamydial antibodies, alone or in combination, predict tubal factor infertility in subfertile patients? Hum Reprod 2003; 18: 2350-2356.
11. ESHRE Capri Workshop Group: Optimal use of infertility diagnostic tests and treatments. Hum Reprod 2000; 15: 723-732.
12. Land JA, Gijsen AP, Kessels AGH, Slobbe MEP, Bruggeman CA: Performance of five serological Chlamydia antibody tests in subfertile women. Hum Reprod 2003; 18: 2621-2627.
13. Eggert-Kruse W, Rohr G, Demirakca T, Rusu R, Naher H, Petzold D, Runnebaum B: Chlamydial serology in 1303 asymptomatic subfertile couples. Hum Reprod 1997; 12: 1464-1475.
14. Fiddelers AA, Land JA, Voss G, Kessels AG, Severens JL: Cost-effectiveness of Chlamydia antibody tests in subfertile women. Hum Reprod 2005; 20: 425-432.
15. Claman P, Amimi MN, Peeling RW, Toye B, Jessamine P: Does serologic evidence of remote Chlamydia trachomatis infection and its heat shock protein (CHSP60) affect in vitro fertilization-embryo transfer outcome? Fertil Steril 1996; 65: 146-149.
16. Tiitinen A, Surcel HM, Halttunen M, Birkelund S, Boigu A, Christiansen G, Koskela P, Morrison SG, Morrison RP, Paavonen J: Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell mediated responses predict tubal factor infertility. Hum Reprod 2006; 21: 1533-1538.
17. Brunham RC, Peeling R, Maclean I, Kosseim ML, Paraskevas M: Chlamydia trachomatis-associated ectopic pregnancy: Serologic and histologic correlates. J Infect Dis 1992; 165: 1076-1081.
18. Patton DL, Cosgrove-Sweeney YT, Kuo CC: Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: A pathogenic mechanism of tubal damage. J Infect Dis 1994; 169: 680-683.
19. Arno JN, Yuan Y, Cleary RE, Morrison RP: Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (HSP60). Fertil Steril 1995; 64: 730-735.
20. Eckert LO, Hawes SE, Wolner-Hansen P, Money DM, Peeling RW, Brunham RC, Stevens CE, Eschenbach DA, Stamm WE: Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. J Infect Dis 1997; 175: 1453-1458.
21. Sziller I, Witkin SS, Ziegert M, CsapóZ, Ujházy A, Papp Z: Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60kDa heat shock protein. Hum Reprod 1998; 13: 1088-1093.
22. Witkin SS, Jeremias J, Neuer A, David SS, Willner E, Witkin KV: Immune recognition of the 60-kDa heat shock protein: Implications for subsequent fertility. Infect Dis Obstet Gynecol 1996; 4: 152-158.
23. Yi Y, Zhong G, Brunham RC: Continous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. Infect Immun 1993; 61: 1117-1120.
24. Cerrone MC, Ma JJ, Stephens RS: Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein. Infect Immun 1991; 59: 79-90.
25. Witkin SS, Ledger WJ: Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortions. Am J Obstet Gynecol 1992; 167: 135-139. Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortions
26. Kligman I, Jeremias J, Rosenwaks Z, Witkin SS: Cell-mediated immune response to human and Escherichia coli 60-kDa heat shock protein in women: Association with a history of spontaneous abortion and endometriosis. Am J Reprod Immunol 1998; 40: 32-36.
27. Neuer A, Mele C, Liu HC, Rosenwaks Z, Witkin SS: Monoclonal antibodies to mammalian heat shock proteins impair mouse embryo development in vitro. Hum Reprod 1998; 13: 987-990.
28. Ziegert M, Witkin SS, Sziller I, Alexander H, Brylla E, Hartig W: Heat shock protein and heat shock protein antibody-complexes in placental tissues. Infect Dis Obstet Gynecol 1999; 7: 180-185.
29. Neuer A, Spandorfer SD, Giraldo P, Dieterle S, Rosenwaks Z, Witkin SS: The role of heat shock proteins in reproduction. Hum Reprod Update 2000; 6: 149-159.
30. Spandorfer SD, Neuer A, LaVerda D, Byrne G, Liu HC, Rosenwaks Z, Witkin SS: Previously undetected Chlamydia trachomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in-vitro fertilization. Hum Reprod 1999; 14: 60-64.