Coenzyme Q metabolism is disturbed in high fat diet-induced non alcoholic fatty liver disease in rats

International Journal of Molecular Sciences

Volumn 13, Issue 2, 2012, Pages 1644-1657

  Bravo, Elena ^a   Palleschi, Simonetta ^a   Rossi, Barbara ^a   Napolitano, Mariarosaria ^a   Tiano, Luca ^b   D'Amore, Emanuela ^a   Botham, Kathleen M ^c  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Antioxidants; Coenzyme q; Non alcoholic fatty liver disease; Oxidative stress; Protein thiol groups; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKADIENE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CONJUGATED DIENE; GLUCOSE; GLUTATHIONE; INSULIN; LIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; OXIDIZED COENZYME Q9; REACTIVE OXYGEN METABOLITE; REDUCED COENZYME Q9; RETINOL; THIOL; TRIACYLGLYCEROL; UBIDECARENONE; UBIQUINONE; UNCLASSIFIED DRUG; FAT INTAKE; THIOL DERIVATIVE; UBIQUINONE 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME METABOLISM; GLUCOSE BLOOD LEVEL; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; LIPID DIET; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; MALE; METABOLIC PARAMETERS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; FAT INTAKE; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHARMACOLOGY; WISTAR RAT;

ANIMALIA; RATTUS;

ANIMALS; DIETARY FATS; LIPOPROTEINS, LDL; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; UBIQUINONE;

EID: 84857676919     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13021644     Document Type: Article

References (38)

1. Adams, L.A.; Angulo, P. Recent concepts in non-alcoholic fatty liver disease. Diabet. Med. 2005, 22, 1129-1133.
2. Svegliati-Baroni, G.; Candelaresi, C.; Saccomanni, S.; Ferretti, G.; Bachetti, T.; Marzioni, M.; Minicis, S.D.; Nobili, L.; Salzano, R.; Omenetti, A.; et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats. Am. J. Pathol. 2006, 169, 846-860.
3. Videla, L.A.; Rodrigo, R.; Araya, J.; Poniachik, J. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol. Med. 2006, 12, 555-558.
4. Day, C.P.; James, O.F.W. Steatohepatitis: A tale of two "hits"? Gastroenterology 1998, 114, 842-845.
5. Anstee, Q.M.; Goldin, R.D. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int. J. Exp. Pathol. 2006, 87, 1-16.
6. Grattagliano, I.; Palmieri, V.O.;Portincasa, P.; Moschetta, A.; Palasciano, G. Oxidative stress-induced risk factors associated with the metabolic syndrome: A unifying hypothesis. J. Nutr. Biochem. 2008, 19, 491-504.
7. Videla, L.A.; Rodrigo, R.; Araya, J.; Poniachik, J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Radic. Biol. Med. 2004, 37, 1499-1507.
8. Videla, L.A.; Rodrigo, R.N.; Orellana, M.; Fernandez, V.; Tapia, G.; Quinones, L.; Varela, N.; Contreras, J.; Lazarte, R.; Csendes, A.; et al. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. Clin. Sci. 2004, 106, 261-268.
9. Day, C.P. Non-alcoholic fatty liver disease: Current concepts and management strategies. Clin. Med. 2006, 6, 19-25.
10. Araya, J.; Rodrigo, R.N.; Videla, L.A.; Thielemann, L.; Orellana, M.; Pettinelli, P.; Poniachik, J. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. 2004, 106, 635-643.
11. Tessari, P.; Coracina, A.; Cosma, A.; Tiengo, A. Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 2009, 19, 291-302.
12. Buqué, X.; Martínez, M.J.; Cano, A; Miquilena-Colina, M.E.; García-Monzón, C.; Aspichueta, P.; Ochoa, B. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. J. Lipid Res. 2010, 51, 500-513.
13. Bentinger, M.; Brismar, K.; Dallner, G. The antioxidant role of coenzyme Q. Mitochondrion 2007, 7, S41-S50.
14. Petrosillo, G.; Portincasa, P.; Grattagliano, I.; Casanova, G.; Matera, M.; Ruggiero, F.M.; Ferri, D.; Paradies, G. Mitochondrial dysfunction in rat with nonalcoholic fatty liver: Involvement of complex I, reactive oxygen species and cardiolipin. Biochim. Biophys. Acta 2007, 1767, 1260-1267.
15. Safwat, G.M.; Pisanò, S.; D'Amore, E.; Borioni, G.; Napolitano, M.; Kamal, A.A.; Ballanti, P.; Botham, K.M.; Bravo, E. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: Does coenzyme Q monomethyl ether have a modulatory effect? Nutrition 2009, 25, 1157-1168.
16. Koteish, A.; Diehl, A. Animal models of steatosis. Semin. Liver Dis. 2001, 21, 89-104.
17. Lieber, C.S.; Leo, M.A.; Mak, K.M.; Xu, Y.; Cao, Q.; Ren, C.; Ponomarenko, A.; de Carli, L.M. Model of nonalcoholic steatohepatitis. Am. J. Clin. Nutr. 2004, 79, 502-509.
18. Cano, A.; Ciaffoni, F.; Safwat, G.M.; Aspichueta, P.; Ochoa, B.; Bravo, E.; Botham, K.M. Hepatic very low density lipoprotein assembly is disturbed in a rat model of non alcoholic fatty liver disease: Is there a role for dietary Coenzyme Q? J. Appl. Physiol. 2009, 107, 707-717.
19. Adams, L.A.; Angulo, P.; Lindor, K.D. Nonalcoholic fatty liver disease. CMAJ 2005, 172, 899-905.
20. Sorbi, D.; Boyton, J.; Lindor, K.D. The ratio of aspartate aminotransferase to alanine aminotransferase: Potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am. J. Gastroenterol. 1999, 94, 1018-1022.
21. Houstis, N.; Rosen, E.D.; Lander, E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440, 944-948.
22. Hermans, N.; Cos, P.; de Meyer, G.R.Y.; Maes, L.; Pieters, L.; Vanden Berghe, D.; Vlietinck, A.J.; de Bruyne, T. Study of potential systemic oxidative stress animal models for the evaluation of antioxidant activity: Status of lipid peroxidation and fat-soluble antioxidants. J. Pharm. Pharmacol. 2007, 59, 131-136.
23. Ferreira, F.M.; Seiça, R.; Oliveira, P.J.; Coxito, P.M.; Moreno, A.J.; Palmeira, C.M.; Santos, M.S. Diabetes induces metabolic adaptations in rat liver mitochondria: Role of coenzyme Q and cardiolipin contents. Biochim. Biophys. Acta 2003, 1639, 113-120.
24. Kohli, R.; Kirby, M.; Xanthakos, S.A.; Softic, S.; Feldstein, A.E.; Saxena, V.; Tang, P.H.; Miles, L.; Miles, M.V.; Balistreri, W.F.; et al. High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. Hepatology 2010, 52, 934-944.
25. Ernster, L.; Dallner, G. Biochemical, physiological and medical aspects of ubiquinone formation. Biochim. Biophys. Acta 1995, 1271, 195-204.
26. Turunen, M.; Olsson, J.; Dallner, G. Metabolism and function of coenzyme Q. Biochim. Biophys. Acta 2004, 1660, 171-199.
27. Quiles, J.A.; Huertas, J.R.; Manas, M.; Battino, M.; Cassinello, M.; Littarru, G.P.; Lenaz, G.; Mataix, F.J. Peroxidative extent and coenzyme Q levels in the rat: Influence of physical training and dietary fats. Mol. Aspects Med. 1994, 15, 89-95.
28. Ahmed, U.; Redgrave, T.G.; Oates, P.S. Effect of dietary fat to produce non-alcoholic fatty liver in the rat. J. Gastroenterol. Hepatol. 2009, 24, 1463-1471.
29. Zhu, M.J.; Sun, L.J.; Liu, Y.Q.; Feng, Y.L.; Tong, H.T.; Hu, Y.H.; Zhao, Z. Blood F2-isoprostanes are significantly associated with abnormalities of lipid status in rats with steatosis. World Gastroenterol. J. 2008, 14, 4677-4683.
30. Folch, J.; Lees, M.; Stanley, G.H.S. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957, 226, 497-509.
31. Friedewald, W.T.; Levy, R.I.; Fredrickson, D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18, 499-502.
32. Pinchuk, I.; Lichtenberg, D. The mechanism of action of antioxidants against lipoprotein peroxidation, evaluation based on kinetic experiments. Prog. Lipid Res. 2002, 41, 279-314.
33. Bradford, M. A sensitive method for quantitation of microgram quantities of protein utilizing the principle of dye-binding. Anal. Biochem. 1976, 72, 248-254.
34. Balercia, G.; Mosca, F.; Mantero, F.; Boscaro, M.; Mancini, A.; Ricciardo-Lamonica, G.; Littarru, G. Coenzyme Q10 supplementation in infertile men with idiopathic asthenozoospermia: An open, uncontrolled pilot study. Fertil. Steril. 2004, 81, 93-98.
35. Nierenberg, D.W.; Lester, D.C. Determination of vitamins A and E in serum and plasma using a simplified clarification method and high-performance liquid chromatography. J. Chromatogr. 1985, 345, 275-284.
36. Pfeiffer, C.M.; Huff, D.L.; Gunter, E.W. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin. Chem. 1999, 45, 290-292.
37. Vassalle, C.; Boni, C.; di Cecco, P.; Ndreu, R.; Zucchelli, G.C. Automation and validation of a fast method for the assessment of in vivo oxidative stress levels. Clin. Chem. Lab. Med. 2006, 44, 1372-1375.
38. Anderson, M.E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 1985, 113, 548-555.