메뉴 건너뛰기




Volumn 279, Issue 5, 2012, Pages 844-855

Xanthine oxidase-generated hydrogen peroxide is a consequence, not a mediator of cell death

Author keywords

cancer; cell death; hydrogen peroxide; oxidative stress; xanthine oxidase

Indexed keywords

CASPASE 3; CASPASE 7; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

EID: 84857659464     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08475.x     Document Type: Article
Times cited : (13)

References (43)
  • 1
    • 0014962562 scopus 로고
    • Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase
    • Fridovich I, (1970) Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase. J Biol Chem 245, 4053-4057.
    • (1970) J Biol Chem , vol.245 , pp. 4053-4057
    • Fridovich, I.1
  • 2
    • 0017154414 scopus 로고
    • Role of ubiquinone in the mitochondrial generation of hydrogen peroxide
    • Boveris A, Cadenas E, &, Stoppani AO, (1976) Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem J 156, 435-444.
    • (1976) Biochem J , vol.156 , pp. 435-444
    • Boveris, A.1    Cadenas, E.2    Stoppani, A.O.3
  • 3
    • 0018393931 scopus 로고
    • NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
    • Takeshige K, &, Minakami S, (1979) NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J 180, 129-135. (Pubitemid 9172746)
    • (1979) Biochemical Journal , vol.180 , Issue.1 , pp. 129-135
    • Takeshige, K.1    Minakami, S.2
  • 4
    • 0016814109 scopus 로고
    • Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease
    • Curnutte JT, Kipnes RS, &, Babior BM, (1975) Defect in pyridine nucleotide dependent superoxide production by a particulate fraction from the cranulocytes of patients with chronic granulomatous disease. N Engl J Med 293, 628-632.
    • (1975) N Engl J Med , vol.293 , pp. 628-632
    • Curnutte, J.T.1    Kipnes, R.S.2    Babior, B.M.3
  • 5
    • 0010668472 scopus 로고
    • NADPH and NADH oxidation by guinea pig polymorphonuclear leucocytes
    • Iyer GY, &, Questel JH, (1963) NADPH and NADH oxidation by guinea pig polymorphonuclear leucocytes. Can J Biochem Physiol 41, 427-434.
    • (1963) Can J Biochem Physiol , vol.41 , pp. 427-434
    • Iyer, G.Y.1    Questel, J.H.2
  • 6
    • 0344827268 scopus 로고    scopus 로고
    • Oxidants in Receptor Tyrosine Kinase Signal Transduction Pathways
    • Aslan M, &, Ozben T, (2003) Oxidants in receptor tyrosine kinase signal transduction pathways. Antioxid Redox Signal 5, 781-788. (Pubitemid 37462061)
    • (2003) Antioxidants and Redox Signaling , vol.5 , Issue.6 , pp. 781-788
    • Aslan, M.1    Ozben, T.2
  • 7
    • 77953800122 scopus 로고    scopus 로고
    • Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells
    • Chang Q, Pan J, Wang X, Zhang Z, Chen F, &, Shi X, (2010) Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res 70, 5127-5135.
    • (2010) Cancer Res , vol.70 , pp. 5127-5135
    • Chang, Q.1    Pan, J.2    Wang, X.3    Zhang, Z.4    Chen, F.5    Shi, X.6
  • 8
    • 77954542760 scopus 로고    scopus 로고
    • REDOX regulation of IL-13 signaling in intestinal epithelial cells: Usage of alternate pathways mediates distinct gene expression patterns
    • Mandal D, Fu P, &, Levine AD, (2010) REDOX regulation of IL-13 signaling in intestinal epithelial cells: usage of alternate pathways mediates distinct gene expression patterns. Cell Signal 22, 1485-1494.
    • (2010) Cell Signal , vol.22 , pp. 1485-1494
    • Mandal, D.1    Fu, P.2    Levine, A.D.3
  • 9
    • 0035525769 scopus 로고    scopus 로고
    • Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species
    • Bellosillo B, Villamor N, Lopez-Guillermo A, Marce S, Esteve J, Campo E, Colomer D, &, Montserrat E, (2001) Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species. Blood 98, 2771-2777.
    • (2001) Blood , vol.98 , pp. 2771-2777
    • Bellosillo, B.1    Villamor, N.2    Lopez-Guillermo, A.3    Marce, S.4    Esteve, J.5    Campo, E.6    Colomer, D.7    Montserrat, E.8
  • 10
    • 23744440681 scopus 로고    scopus 로고
    • Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
    • DOI 10.1016/j.abb.2005.06.015, PII S0003986105002602
    • Wagner BA, Evig CB, Reszka KJ, Buettner GR, &, Burns CP, (2005) Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells. Arch Biochem Biophys 440, 181-190. (Pubitemid 41140383)
    • (2005) Archives of Biochemistry and Biophysics , vol.440 , Issue.2 , pp. 181-190
    • Wagner, B.A.1    Evig, C.B.2    Reszka, K.J.3    Buettner, G.R.4    Burns, C.P.5
  • 11
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
    • DOI 10.1158/1078-0432.CCR-03-0561
    • Pei XY, Dai Y, &, Grant S, (2004) Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin Cancer Res 10, 3839-3852. (Pubitemid 38697620)
    • (2004) Clinical Cancer Research , vol.10 , Issue.11 , pp. 3839-3852
    • Pei, X.-Y.1    Dai, Y.2    Grant, S.3
  • 12
    • 14944349512 scopus 로고    scopus 로고
    • Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine
    • DOI 10.1182/blood-2004-06-2205
    • Shanafelt TD, Lee YK, Bone ND, Strege AK, Narayanan VL, Sausville EA, Geyer SM, Kaufmann SH, &, Kay NE, (2005) Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine. Blood 105, 2099-2106. (Pubitemid 40731798)
    • (2005) Blood , vol.105 , Issue.5 , pp. 2099-2106
    • Shanafelt, T.D.1    Lee, Y.K.2    Bone, N.D.3    Strege, A.K.4    Narayanan, V.L.5    Sausville, E.A.6    Geyer, S.M.7    Kaufmann, S.H.8    Kay, N.E.9
  • 13
    • 0344404115 scopus 로고
    • The degradation of deoxyribonucleic acid by new tumour inhibiting compounds: The intermediate formation of hydrogen peroxide
    • Berneis K, Kofler M, Bollag W, Kaiser A, &, Langemann A, (1963) The degradation of deoxyribonucleic acid by new tumour inhibiting compounds: the intermediate formation of hydrogen peroxide. Experientia 19, 132-133.
    • (1963) Experientia , vol.19 , pp. 132-133
    • Berneis, K.1    Kofler, M.2    Bollag, W.3    Kaiser, A.4    Langemann, A.5
  • 14
    • 0022270570 scopus 로고
    • Oxyradical formation during redox cycling of the bleomycin-iron (III) complex by NADPH-cytochrome P-450 reductase
    • DOI 10.1016/0006-2952(85)90152-2
    • Mahmutoglu I, &, Kappus H, (1985) Oxy radical formation during redox cycling of the bleomycin-iron(III) complex by NADPH-cytochrome P-450 reductase. Biochem Pharmacol 34, 3091-3094. (Pubitemid 16216384)
    • (1985) Biochemical Pharmacology , vol.34 , Issue.17 , pp. 3091-3094
    • Mahmutoglu, I.1    Kappus, H.2
  • 15
    • 0031987938 scopus 로고    scopus 로고
    • Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (review)
    • Muller I, Niethammer D, &, Bruchelt G, (1998) Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (review). Int J Mol Med 1, 491-494.
    • (1998) Int J Mol Med , vol.1 , pp. 491-494
    • Muller, I.1    Niethammer, D.2    Bruchelt, G.3
  • 16
    • 39749098572 scopus 로고    scopus 로고
    • Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells
    • DOI 10.1007/s10565-007-9022-1
    • Rudolf E, Rudolf K, &, Cervinka M, (2008) Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells. Cell Biol Toxicol 24, 123-141. (Pubitemid 351311388)
    • (2008) Cell Biology and Toxicology , vol.24 , Issue.2 , pp. 123-141
    • Rudolf, E.1    Rudolf, K.2    Cervinka, M.3
  • 17
    • 12244282873 scopus 로고    scopus 로고
    • Mechanism of taxol-induced apoptosis in human SKOV3 ovarian carcinoma cells
    • Ahn HJ, Kim YS, Kim JU, Han SM, Shin JW, &, Yang HO, (2004) Mechanism of taxol-induced apoptosis in human SKOV3 ovarian carcinoma cells. J Cell Biochem 91, 1043-1052.
    • (2004) J Cell Biochem , vol.91 , pp. 1043-1052
    • Ahn, H.J.1    Kim, Y.S.2    Kim, J.U.3    Han, S.M.4    Shin, J.W.5    Yang, H.O.6
  • 18
    • 0041488913 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway
    • Alonso M, Tamasdan C, Miller DC, &, Newcomb EW, (2003) Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2, 139-150.
    • (2003) Mol Cancer Ther , vol.2 , pp. 139-150
    • Alonso, M.1    Tamasdan, C.2    Miller, D.C.3    Newcomb, E.W.4
  • 19
    • 0034660880 scopus 로고    scopus 로고
    • The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase
    • Li S, Yan T, Yang JQ, Oberley TD, &, Oberley LW, (2000) The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res 60, 3927-3939. (Pubitemid 32204589)
    • (2000) Cancer Research , vol.60 , Issue.14 , pp. 3927-3939
    • Li, S.1    Yan, T.2    Yang, J.-Q.3    Oberley, T.D.4    Oberley, L.W.5
  • 20
    • 0034333151 scopus 로고    scopus 로고
    • Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2)
    • Rodriguez AM, Carrico PM, Mazurkiewicz JE, &, Melendez JA, (2000) Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2). Free Radical Biol Med 29, 801-813.
    • (2000) Free Radical Biol Med , vol.29 , pp. 801-813
    • Rodriguez, A.M.1    Carrico, P.M.2    Mazurkiewicz, J.E.3    Melendez, J.A.4
  • 21
    • 79955928897 scopus 로고    scopus 로고
    • Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells
    • Czupryna J, &, Tsourkas A, (2011) Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. PLoS One 6, e20073.
    • (2011) PLoS One , vol.6
    • Czupryna, J.1    Tsourkas, A.2
  • 22
    • 0028316195 scopus 로고
    • Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C
    • Jarvis WD, Turner AJ, Povirk LF, Traylor RS, &, Grant S, (1994) Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54, 1707-1714. (Pubitemid 24116174)
    • (1994) Cancer Research , vol.54 , Issue.7 , pp. 1707-1714
    • Jarvis, W.D.1    Turner, A.J.2    Povirk, L.F.3    Traylor, R.S.4    Grant, S.5
  • 23
    • 0032562669 scopus 로고    scopus 로고
    • Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production
    • DOI 10.1016/S0304-3940(98)00242-0, PII S0304394098002420
    • Ahlemeyer B, &, Krieglstein J, (1998) Retinoic acid reduces staurosporine-induced apoptotic damage in chick embryonic neurons by suppressing reactive oxygen species production. Neurosci Lett 246, 93-96. (Pubitemid 28207084)
    • (1998) Neuroscience Letters , vol.246 , Issue.2 , pp. 93-96
    • Ahlemeyer, B.1    Krieglstein, J.2
  • 24
    • 0033992544 scopus 로고    scopus 로고
    • Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis
    • DOI 10.1016/S0197-0186(99)00101-1, PII S0197018699001011
    • Ahlemeyer B, &, Krieglstein J, (2000) Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis. Neurochem Int 36, 1-5. (Pubitemid 29481778)
    • (2000) Neurochemistry International , vol.36 , Issue.1 , pp. 1-5
    • Ahlemeyer, B.1    Krieglstein, J.2
  • 25
    • 0034541212 scopus 로고    scopus 로고
    • Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: Initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim)
    • Heerdt BG, Houston MA, Mariadason JM, &, Augenlicht LH, (2000) Dissociation of staurosporine-induced apoptosis from G2-M arrest in SW620 human colonic carcinoma cells: initiation of the apoptotic cascade is associated with elevation of the mitochondrial membrane potential (deltapsim). Cancer Res 60, 6704-6713.
    • (2000) Cancer Res , vol.60 , pp. 6704-6713
    • Heerdt, B.G.1    Houston, M.A.2    Mariadason, J.M.3    Augenlicht, L.H.4
  • 26
    • 0032006868 scopus 로고    scopus 로고
    • Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells
    • DOI 10.1002/(SICI)1097-4547(19980201)51:3<293::AID-JNR3>3.0.CO;2-B
    • Kruman I, Guo Q, &, Mattson MP, (1998) Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 51, 293-308. (Pubitemid 28078461)
    • (1998) Journal of Neuroscience Research , vol.51 , Issue.3 , pp. 293-308
    • Kruman, I.1    Guo, Q.2    Mattson, M.P.3
  • 28
    • 0013966678 scopus 로고
    • Enzymatic and metabolic studies with allopurinol
    • Elion GB, (1966) Enzymatic and metabolic studies with allopurinol. Ann Rheum Dis 25, 608-614.
    • (1966) Ann Rheum Dis , vol.25 , pp. 608-614
    • Elion, G.B.1
  • 29
    • 0025173324 scopus 로고
    • Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. the confounding problem of adventitious iron bound to xanthine oxidase
    • Britigan BE, Pou S, Rosen GM, Lilleg DM, &, Buettner GR, (1990) Hydroxyl radical is not a product of the reaction of xanthine oxidase and xanthine. The confounding problem of adventitious iron bound to xanthine oxidase. J Biol Chem 265, 17533-17538.
    • (1990) J Biol Chem , vol.265 , pp. 17533-17538
    • Britigan, B.E.1    Pou, S.2    Rosen, G.M.3    Lilleg, D.M.4    Buettner, G.R.5
  • 30
    • 33646499185 scopus 로고    scopus 로고
    • Superoxide radical production by allopurinol and xanthine oxidase
    • Galbusera C, Orth P, Fedida D, &, Spector T, (2006) Superoxide radical production by allopurinol and xanthine oxidase. Biochem Pharmacol 71, 1747-1752.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1747-1752
    • Galbusera, C.1    Orth, P.2    Fedida, D.3    Spector, T.4
  • 31
    • 0025356672 scopus 로고
    • Antioxidant capacity of allopurinol in biological systems
    • Faure M, Lissi EA, &, Videla LA, (1990) Antioxidant capacity of allopurinol in biological systems. Biochem Int 21, 357-366. (Pubitemid 20205834)
    • (1990) Biochemistry International , vol.21 , Issue.2 , pp. 357-366
    • Faure, M.1    Lissi, E.A.2    Videla, L.A.3
  • 32
    • 67449085150 scopus 로고    scopus 로고
    • Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
    • George J, &, Struthers AD, (2009) Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress. Vasc Health Risk Manag 5, 265-272.
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 265-272
    • George, J.1    Struthers, A.D.2
  • 33
    • 0023834145 scopus 로고
    • On the specificity of allopurinol and oxypurinol as inhibitors of xanthine oxidase. A pulse radiolysis determination of rate constants for reaction of allopurinol and oxypurinol with hydroxyl radicals
    • Hoey BM, Butler J, &, Halliwell B, (1988) On the specificity of allopurinol and oxypurinol as inhibitors of xanthine oxidase. A pulse radiolysis determination of rate constants for reaction of allopurinol and oxypurinol with hydroxyl radicals. Free Radical Res Commun 4, 259-263. (Pubitemid 18073062)
    • (1988) Free Radical Research Communications , vol.4 , Issue.4 , pp. 259-263
    • Hoey, B.M.1    Butler, J.2    Halliwell, B.3
  • 34
    • 0029741654 scopus 로고    scopus 로고
    • Allopurinol: Discrimination of antioxidant from enzyme inhibitory activities
    • DOI 10.1016/0891-5849(96)00158-X
    • Klein AS, Joh JW, Rangan U, Wang D, &, Bulkley GB, (1996) Allopurinol: discrimination of antioxidant from enzyme inhibitory activities. Free Radical Biol Med 21, 713-717. (Pubitemid 26331102)
    • (1996) Free Radical Biology and Medicine , vol.21 , Issue.5 , pp. 713-717
    • Klein, A.S.1    Joh, J.W.2    Rangan, U.3    Wang, D.4    Bulkley, G.B.5
  • 35
    • 17644401321 scopus 로고    scopus 로고
    • Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase
    • DOI 10.1007/s10495-005-6073-8
    • Chen GG, Sin FL, Leung BC, Ng HK, &, Poon WS, (2005) Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase. Apoptosis 10, 185-192. (Pubitemid 40558126)
    • (2005) Apoptosis , vol.10 , Issue.1 , pp. 185-192
    • Chen, G.G.1    Sin, F.L.F.2    Leung, B.C.S.3    Ng, H.K.4    Poon, W.S.5
  • 36
    • 77956373630 scopus 로고    scopus 로고
    • Protective effect of 4,4'-diaminodiphenylsulphone against oxidative stress but not to apoptotic stress in human diploid fibroblasts
    • Cho SC, Rhim JH, Son YH, Lee SJ, &, Park SC, (2010) Protective effect of 4,4'-diaminodiphenylsulphone against oxidative stress but not to apoptotic stress in human diploid fibroblasts. Free Radical Res 44, 871-880.
    • (2010) Free Radical Res , vol.44 , pp. 871-880
    • Cho, S.C.1    Rhim, J.H.2    Son, Y.H.3    Lee, S.J.4    Park, S.C.5
  • 37
    • 0027237540 scopus 로고
    • Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells
    • DOI 10.1016/0006-2952(93)90512-U
    • Skladanowski A, &, Konopa J, (1993) Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem Pharmacol 46, 375-382. (Pubitemid 23239986)
    • (1993) Biochemical Pharmacology , vol.46 , Issue.3 , pp. 375-382
    • Skladanowski, A.1    Konopa, J.2
  • 38
    • 0030913171 scopus 로고    scopus 로고
    • Factors affecting topotecan-induced programmed cell death: Adhesion protects cells from apoptosis and impairs cleavage of poly(ADP- ribose)polymerase
    • Whitacre CM, &, Berger NA, (1997) Factors affecting topotecan-induced programmed cell death: adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose)polymerase. Cancer Res 57, 2157-2163. (Pubitemid 27247032)
    • (1997) Cancer Research , vol.57 , Issue.11 , pp. 2157-2163
    • Whitacre, C.M.1    Berger, N.A.2
  • 40
    • 71349085674 scopus 로고    scopus 로고
    • New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue
    • Franke JC, Plotz M, Prokop A, Geilen CC, Schmalz HG, &, Eberle J, (2010) New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue. Biochem Pharmacol 79, 575-586.
    • (2010) Biochem Pharmacol , vol.79 , pp. 575-586
    • Franke, J.C.1    Plotz, M.2    Prokop, A.3    Geilen, C.C.4    Schmalz, H.G.5    Eberle, J.6
  • 41
    • 0344012006 scopus 로고    scopus 로고
    • Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
    • DOI 10.1016/j.freeradbiomed.2003.08.022
    • Gil J, Almeida S, Oliveira CR, &, Rego AC, (2003) Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis. Free Radical Biol Med 35, 1500-1514. (Pubitemid 37452475)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.11 , pp. 1500-1514
    • Gil, J.1    Almeida, S.2    Oliveira, C.R.3    Rego, A.C.4
  • 42
    • 43049160756 scopus 로고    scopus 로고
    • Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death
    • DOI 10.1016/j.cell.2008.03.032, PII S0092867408004613
    • Martinvalet D, Dykxhoorn DM, Ferrini R, &, Lieberman J, (2008) Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell 133, 681-692. (Pubitemid 351636303)
    • (2008) Cell , vol.133 , Issue.4 , pp. 681-692
    • Martinvalet, D.1    Dykxhoorn, D.M.2    Ferrini, R.3    Lieberman, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.